Anti-Lipolysis Induced by Insulin in Diverse Pathophysiologic Conditions of Adipose Tissue
Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy, 2020 As an important energy reservoir, adipose tissue maintains lipid balance and regulates energy metabolism. When the body requires energy, adipocytes provide fatty acids to peripheral tissues through lipolysis. Insulin plays an important role in regulating
Jia Zhao +4 more
semanticscholar +1 more source
Relationship between cyclic AMP production and lipolysis induced by forskolin in rat fat cells.
Journal of Lipid Research, 1992 Forskolin (7 beta-acetoxy-8, 13-epoxy-1 alpha,6 beta,9 alpha-trihydroxy-labd-14-ene-11-one) induced both cyclic AMP production and lipolysis in intact fat cells, but stimulated lipolysis without increasing cyclic AMP at a concentration of 10(-5) M ...
H Okuda, C Morimoto, T Tsujita
doaj +1 more source
Inflammasome-driven catecholamine catabolism in macrophages blunts lipolysis in the aged
Nature, 2017 Catecholamine-induced lipolysis, the first step in the generation of energy substrates by the hydrolysis of triglycerides, declines with age. The defect in the mobilization of free fatty acids in the elderly is accompanied by increased visceral adiposity,
Christina Camell +12 more
semanticscholar +1 more source
In preeclampsia, maternal third trimester subcutaneous adipocyte lipolysis is more resistant to suppression by insulin than in healthy pregnancy [PDF]
, 2014 Obesity increases preeclampsia risk, and maternal dyslipidemia may result from exaggerated adipocyte lipolysis. We compared adipocyte function in preeclampsia with healthy pregnancy to establish whether there is increased lipolysis.
Forrest, Rachel. +5 more
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Adipocyte lipolysis drives acute stress-induced insulin resistance
Scientific Reports, 2020 Stress hyperglycemia and insulin resistance are evolutionarily conserved metabolic adaptations to severe injury including major trauma, burns, or hemorrhagic shock (HS).
V. Raje +13 more
semanticscholar +1 more source
Journal of Lipid Research, 1987 3T3-L1 adipocytes were used to test the hypothesis that hormone-sensitive lipolysis and lipoprotein lipase activity might be regulated in a reciprocal manner.
S S Chernick +3 more
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Periparturient lipolysis and oxylipid biosynthesis in bovine adipose tissues. [PDF]
PLoS ONE, 2017 The periparturient period of dairy cows is characterized by intense lipolysis in adipose tissues (AT), which induces the release of free fatty acids (FFA) into circulation.
G Andres Contreras +6 more
doaj +1 more source
The glucocorticoid-Angptl4-ceramide axis induces insulin resistance through PP2A and PKCζ. [PDF]
, 2017 Chronic glucocorticoid exposure is associated with the development of insulin resistance. We showed that glucocorticoid-induced insulin resistance was attenuated upon ablation of Angptl4, a glucocorticoid target gene encoding the secreted protein ...
Benjamin, Daniel I +8 more
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Oléagineux, Corps gras, Lipides, 2010 Labrasol® and Gelucire® 44/14 are lipid-based excipients used for the oral drug delivery of poorly water-soluble drugs. These macrogolglycerides are composed of acylglycerols and PEG esters, potential substrates of digestive lipases.
Fernandez Sylvie +2 more
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Trichostatin A modulates thiazolidinedione-mediated suppression of tumor necrosis factor α-induced lipolysis in 3T3-L1 adipocytes. [PDF]
PLoS ONE, 2013 In obesity, high levels of tumor necrosis factor α (TNFα) stimulate lipolysis in adipocytes, leading to hyperlipidemia and insulin resistance. Thiazolidinediones (TZDs), the insulin-sensitizing drugs, antagonize TNFα-induced lipolysis in adipocytes ...
Juu-Chin Lu +5 more
doaj +1 more source