Results 41 to 50 of about 6,907 (199)
Breaking fat: The regulation and mechanisms of lipophagy [PDF]
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2017 Lipophagy is defined as the autophagic degradation of intracellular lipid droplets (LDs). While the field of lipophagy research is relatively young, an expansion of research in this area over the past several years has greatly advanced our understanding of lipophagy.
Ryan J. Schulze +2 more
openaire +2 more sources
Regulation of lipid stores and metabolism by lipophagy [PDF]
Cell Death & Differentiation, 2012 Intracellular lipids are stored in lipid droplets (LDs) and metabolized by cytoplasmic neutral hydrolases to supply lipids for cell use. Recently, an alternative pathway of lipid metabolism through the lysosomal degradative pathway of autophagy has been described and termed lipophagy.
K, Liu, M J, Czaja
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Lipid metabolism and lipophagy in cancer
Biochemical and Biophysical Research Communications, 2018 The tumor microenvironment can be hypoxic, acidic, and deficient in nutrients, thus causing the metabolism of tumor cells as well as the neighboring stromal cells to be remodelled to facilitate tumor survival, proliferation, and metastasis. Abnormal tumor lipid metabolism is a fairly new field, which has received attention in the past few years.
Meenu Maan +3 more
openaire +3 more sources
Mycophenolic acid (MPA) modulates host cellular autophagy progression in sub genomic dengue virus-2 replicon cells [PDF]
, 2019 Cellular autophagy (Macrophagy) is a self-degradative process, executed through the network of autophagy associated genes (ATGs) encoded proteins. Both in vitro and in vivo studies suggest that dengue virus (DENV) induces autophagy and supports the viral
Dungdung, Ranjeet +4 more
core +1 more source
Lysosomal acid lipase: at the crossroads of normal and atherogenic cholesterol metabolism [PDF]
, 2015 Unregulated cellular uptake of apolipoprotein B-containing lipoproteins in the arterial intima leads to the formation of foam cells in atherosclerosis. Lysosomal acid lipase (LAL) plays a crucial role in both lipoprotein lipid catabolism and excess lipid
Gordon A. Francis, Joshua A. Dubland
core +2 more sources
陆军军医大学学报, 2023 Objective To investigate the effect of resveratrol (RSV) on enhancing hepatic lipolysis and lipophagy through perilipin 2 (PLIN2), and elucidate its underlying mechanism.
YANG Yilin +3 more
doaj +1 more source
Lipolysis and lipophagy in lipid storage myopathies
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2016 Triglycerides droplets are massively stored in muscle in Lipid Storage Myopathies (LSM). We studied in muscle regulators of lipophagy, the expression of the transcription factor-EB (TFEB) (a master regulator of lysosomal biogenesis), and markers of autophagy which are induced by starvation and exert a transcriptional control on lipid catabolism.We ...
Angelini, C +3 more
openaire +3 more sources
Ltc1 is an ER-localized sterol transporter and a component of ER-mitochondria and ER-vacuole contacts. [PDF]
, 2015 Organelle contact sites perform fundamental functions in cells, including lipid and ion homeostasis, membrane dynamics, and signaling. Using a forward proteomics approach in yeast, we identified new ER-mitochondria and ER-vacuole contacts specified by an
Murley, Andrew +5 more
core +2 more sources
Chloroplast damage induced by the inhibition of fatty acid synthesis triggers autophagy in chlamydomonas [PDF]
, 2018 Fatty acids are synthesized in the stroma of plant and algal chloroplasts by the fatty acid synthase complex. Newly synthesized fatty acids are then used to generate plastidial lipids that are essential for chloroplast structure and function.
Andrés Garrido, Ascensión +4 more
core +1 more source
Autophagy couteracts weight gain, lipotoxicity and pancreatic ß-cell death upon hypercaloric pro-diabetic regimens [PDF]
, 2017 GK is supported by the Ligue contre le Cancer (équipe labelisée); Agence National de la Recherche (ANR); Association pour la recherche sur le cancer (ARC); Cancéropôle Ile-de-France; Institut National du Cancer (INCa); Fondation Bettencourt-Schueller ...
Bárcena Fernández, Clea +3 more
core +2 more sources