Results 61 to 70 of about 7,072 (199)
British Journal of Pharmacology, EarlyView.Abstract Background and Purpose Extensive evidence indicates that lipid accumulation causes renal tubular injury, which further contributes to diabetic nephropathy (DN) progression. Short‐chain fatty acids (SCFAs) play an important role in the maintenance of cellular metabolic health.
Jiayin Tao +12 more
wiley +1 more source
Autophagy, lipophagy and lysosomal lipid storage disorders
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2016 Autophagy is a catabolic process with an essential function in the maintenance of cellular and tissue homeostasis. It is primarily recognised for its role in the degradation of dysfunctional proteins and unwanted organelles, however in recent years the range of autophagy substrates has also been extended to lipids.
Ward, Carl +7 more
openaire +4 more sources
The Role of Lipophagy in the Development and Treatment of Non-Alcoholic Fatty Liver Disease
Frontiers in Endocrinology, 2021 Non-alcoholic fatty liver disease (NAFLD) or metabolic (dysfunction) associated liver disease (MAFLD), is, with a global prevalence of 25%, the most common liver disorder worldwide.
Aldo Grefhorst +5 more
doaj +1 more source
Genetic aberrations in macroautophagy genes leading to diseases [PDF]
, 2018 The catabolic process of macroautophagy, through the rapid degradation of unwanted cellular components, is involved in a multitude of cellular and organismal functions that are essential to maintain homeostasis.
Klionsky, Daniel J +2 more
core +1 more source
Emerging risk factors influencing the occurrence of peri‐implantitis
Periodontology 2000, EarlyView.Abstract Background The objective of the present review is to explore the evidence and biological plausibility of factors that may expose dental implants to a greater likelihood of developing peri‐implantitis. Material and Methods An electronic screening on the PubMed library the was carried out to identify potential emerging factors that influence the
Alberto Monje +3 more
wiley +1 more source
Garlic-derived S-allylmercaptocysteine ameliorates nonalcoholic fatty liver disease in a rat model through inhibition of apoptosis and enhancing autophagy [PDF]
, 2013 published_or_final_versio
Chang, RCC +6 more
core +3 more sources
The Journal of Physiology, EarlyView.Abstract figure legend Mitochondria are highly dynamic organelles that continuously remodel their architecture through coordinated cycles of fusion and fission. This review examines the four key GTPases that orchestrate mitochondrial dynamics in mammals: MFN1, MFN2, OPA1, and DRP1.
Rémi Chaney +4 more
wiley +1 more source
Establishment of lal-/- myeloid lineage cell line that resembles myeloid-derived suppressive cells [PDF]
, 2015 Myeloid-derived suppressor cells (MDSCs) in mouse are inflammatory cells that play critical roles in promoting cancer growth and metastasis by directly stimulating cancer cell proliferation and suppressing immune surveillance.
Ding, Xinchun +3 more
core +7 more sources
Advanced Science, Volume 13, Issue 19, 2 April 2026.Progressive stiffening of the hepatic extracellular matrix and free fatty acid overload activate the mechanosensor Piezo1 in steatotic hepatocytes, inducing calcium influx and nuclear translocation of Yes‐associated protein. YAP‐dependent nuclear signaling further drives inflammatory and fibrotic gene programs, lipid metabolic reprogramming, and ...
Juan Ma +15 more
wiley +1 more source
The Role of Macrophage Lipophagy in Reverse Cholesterol Transport [PDF]
Endocrinology and Metabolism, 2017 Macrophage cholesterol efflux is a central step in reverse cholesterol transport, which helps to maintain cholesterol homeostasis and to reduce atherosclerosis.
Se-Jin Jeong, Mi-Ni Lee, Goo Taeg Oh
doaj +1 more source