Autophagy in plants and algae [PDF]
, 2014 Autophagy is a major cellular degradation pathway in which materials are delivered to the vacuole in double-membrane vesicles known as autophagosomes, broken down, and recycled (Li and Vierstra, 2012; Liu and Bassham, 2012).
Bassham, Diane +2 more
core +4 more sources
Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead. [PDF]
, 2015 Lifestyle factors are responsible for a considerable portion of cancer incidence worldwide, but credible estimates from the World Health Organization and the International Agency for Research on Cancer (IARC) suggest that the fraction of cancers ...
Ab Hamid, Hasiah +173 more
core +11 more sources
Emerging mechanistic insights of selective autophagy in hepatic diseases
Frontiers in Pharmacology, 2023 Macroautophagy (hereafter referred to as autophagy), a highly conserved metabolic process, regulates cellular homeostasis by degrading dysfunctional cytosolic constituents and invading pathogens via the lysosomal system.
Abdul Alim Al-Bari +10 more
doaj +1 more source
Streptozotocin-induced diabetes mellitus affects lysosomal enzymes in rat liver [PDF]
, 2014 It has been previously shown that dextran sulfate administered to diabetic rats accumulates in the liver and kidney, and this could be due to a malfunction of the lysosomal digestive pathway.
Aguiar, Jair Adriano Kopke +3 more
core +1 more source
LKB1–AMPK Signaling Pathway in Cardiovascular and Other Diseases
MedComm, Volume 7, Issue 3, March 2026.The LKB1–AMPK pathway has a central regulatory role in various diseases. Dysfunction of this pathway can lead to pathological processes in cardiovascular diseases (atrial fibrillation, myocardial infarction, myocardial hypertrophy, atherosclerosis), metabolic diseases (diabetes and kidney disease), neurodegenerative diseases (Alzheimer's disease ...
Zhuo Chen, Qin Yang, Guo‐Wei He
wiley +1 more source
Physiological Reports, 2020 Caffeine has been shown to directly increase fatty acid oxidation, in part, by promoting mitochondrial biogenesis. Mitochondrial biogenesis is often coupled with mitophagy, the autophagy‐lysosomal degradation of mitochondria.
David S. Enyart +7 more
doaj +1 more source
PACAP neuropeptide promotes Hepatocellular Protection via CREB-KLF4 dependent autophagy in mouse liver Ischemia Reperfusion Injury. [PDF]
, 2020 Organ ischemia reperfusion injury (IRI), associated with acute hepatocyte death, remains an unresolved problem in clinical orthotopic liver transplantation (OLT).
Busuttil, Ronald W +9 more
core
Loss of the RNA polymerase III repressor MAF1 confers obesity resistance. [PDF]
, 2015 MAF1 is a global repressor of RNA polymerase III transcription that regulates the expression of highly abundant noncoding RNAs in response to nutrient availability and cellular stress. Thus, MAF1 function is thought to be important for metabolic economy.
Auwerx, J. +18 more
core +1 more source
Insights Into Macrophage Ferroptosis: Implications for Atherosclerosis
Cell Proliferation, Volume 59, Issue 3, March 2026.Macrophage ferroptosis drives atherosclerosis by enhancing oxidative stress and inflammation, accelerating plaque progression and instability. Targeting macrophage ferroptosis presents a promising therapeutic strategy for atherosclerosis treatment.
Xiehui Chen, Xiangbo Liu, Changchun Zeng
wiley +1 more source
Lipid partitioning at the nuclear envelope controls membrane biogenesis. [PDF]
, 2015 Partitioning of lipid precursors between membranes and storage is crucial for cell growth, and its disruption underlies pathologies such as cancer, obesity, and type 2 diabetes.
Abreu, Susana +6 more
core +3 more sources