Results 81 to 90 of about 7,072 (199)
Molecular Microbiology, Volume 125, Issue 3, Page 185-202, March 2026.Human macrophage transcriptomic responses to Mycobacterium avium (Mav), a major cause of nontuberculous lung disease, were compared to Mycobacterium tuberculosis (Mtb). Both infections activated overlapping immune pathways, including cytokine signaling and GPCRs involved in lipid metabolism, while phospholipases were more strongly regulated by Mav and ...
Gül Kilinç +4 more
wiley +1 more source
Ethanol-triggered Lipophagy Requires SQSTM1 in AML12 Hepatic Cells [PDF]
Scientific Reports, 2017 AbstractEthanol-induced hepatic lipophagy plays an important cytoprotective role against liver injury, but its mechanism is not fully determined. In the present study, ethanol-induced lipophagy was studied in an immortalized mouse hepatocyte line, AML12.
Wang, Lin +5 more
openaire +2 more sources
Journal of Lipid Research, 2019 Fatty acid translocase cluster of differentiation (CD36) is a multifunctional membrane protein that facilitates the uptake of long-chain fatty acids. Lipophagy is autophagic degradation of lipid droplets.
Yun Li +10 more
doaj +1 more source
Role of autophagy in the control of food intake [PDF]
, 2015 Treballs Finals de Grau de Farmàcia, Facultat de Farmàcia, Universitat de Barcelona, 2015. Tutora: Dolors Serra i Cucurull.[eng] Autophagy is an intracellular pathway which has been well characterised since many years ago. It is present in all cell types
Balañá García-Vela, Blanca
core
Sphingolipids as emerging mediators in retina degeneration [PDF]
, 2019 The sphingolipids ceramide (Cer), sphingosine-1-phosphate (S1P), sphingosine (Sph), and ceramide-1-phosphate (C1P) are key signaling molecules that regulate major cellular functions.
Prado Spalm, Facundo Heber +3 more
core +1 more source
Unraveling Lysosomal Exocytosis: From Molecular Mechanisms to Physiological Functions
Traffic, Volume 27, Issue 1, March 2026.Lysosomal exocytosis is propelled by specific molecular mechanisms that direct its microtubule‐dependent transport and subsequent fusion with the plasma membrane. This process fulfills essential physiological functions such as plasma membrane repair, maintenance of cellular homeostasis, and participation in signal transduction.
Shanshan Jiang +7 more
wiley +1 more source
Expanded genetic screening in Caenorhabditis elegans identifies new regulators and an inhibitory role for NAD+ in axon regeneration. [PDF]
, 2018 The mechanisms underlying axon regeneration in mature neurons are relevant to the understanding of normal nervous system maintenance and for developing therapeutic strategies for injury.
Andrusiak, Matthew G +10 more
core +1 more source
Advanced Science, Volume 13, Issue 9, 13 February 2026.This study demonstrates that BNNT exposure disrupts lipid homeostasis in bronchial epithelial cell cultures and activates eicosanoid lipid biosynthesis, producing inflammatory lipid mediators like leukotrienes. These effects are more pronounced in asthmatic cell cultures compared to healthy ones.
Govind Gupta +14 more
wiley +1 more source
Advanced Science, Volume 13, Issue 10, 18 February 2026.Microglial AXL drives white matter repair after stroke by orchestrating the cleanup of myelin debris. Mechanistically, AXL signals through EGR1 to boost Smpd1 transcription, regulating sphingolipid metabolism and preventing lipid droplet toxicity. Restoring the pathway with ASM therapy mitigates damage, positioning AXL as a key node for therapeutic ...
Junqiu Jia +13 more
wiley +1 more source
Lipid Droplet Formation and Lipophagy in Fatty Liver Disease [PDF]
Seminars in Liver Disease, 2019 AbstractLipid droplets (LDs) are key sites of neutral lipid storage that can be found in all cells. Metabolic imbalances between the synthesis and degradation of LDs can result in the accumulation of significant amounts of lipid deposition, a characteristic feature of hepatocytes in patients with fatty liver disease, a leading indication for liver ...
Ryan J, Schulze, Mark A, McNiven
openaire +2 more sources