Results 21 to 30 of about 105,029 (97)

Effects of the Variants of Activin Receptor-like Kinase-1 and 2 on the Lipid Profile of Patients with Coronary Heart Disease

İstanbul Medical Journal, 2020
Introduction:Coronary heart disease (CHD) due to atherosclerosis is a multifactorial disease with high morbidity caused by interaction of various genetic and environmental factors.
Ayşegül Başak Akadam Teker, Erhan Teker, Hülya Yılmaz Aydoğan   +2 more
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The LXR-IDOL axis defines a clathrin-, caveolae-, and dynamin-independent endocytic route for LDLR internalization and lysosomal degradation

Journal of Lipid Research, 2013
Low density lipoprotein (LDL) cholesterol is taken up into cells via clathrin-mediated endocytosis of the LDL receptor (LDLR). Following dissociation of the LDLR-LDL complex, LDL is directed to lysosomes whereas the LDLR recycles to the plasma membrane ...
Vincenzo Sorrentino, Jessica K. Nelson, Elena Maspero, André R.A. Marques, Lilith Scheer, Simona Polo, Noam Zelcer   +6 more
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A PCSK9-binding antibody that structurally mimics the EGF(A) domain of LDL-receptor reduces LDL cholesterol in vivo1[S]

Journal of Lipid Research, 2011
Proprotein convertase subtilisin-like/kexin type 9 (PCSK9) regulates LDL cholesterol levels by inhibiting LDL receptor (LDLr)-mediated cellular LDL uptake. We have identified a fragment antigen-binding (Fab) 1D05 which binds PCSK9 with nanomolar affinity.
Yan G. Ni, Stefania Di Marco, Jon H. Condra, Laurence B. Peterson, Weirong Wang, Fubao Wang, Shilpa Pandit, Holly A. Hammond, Ray Rosa, Richard T. Cummings, Dana D. Wood, Xiaomei Liu, Matthew J. Bottomley, Xun Shen, Rose M. Cubbon, Sheng-ping Wang, Douglas G. Johns, Cinzia Volpari, Lora Hamuro, Jayne Chin, Lingyi Huang, Jing Zhang Zhao, Salvatore Vitelli, Peter Haytko, Douglas Wisniewski, Lyndon J. Mitnaul, Carl P. Sparrow, Brian Hubbard, Andrea Carfí, Ayesha Sitlani   +29 more
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Evolving targets for lipid‐modifying therapy

EMBO Molecular Medicine, 2014
The pathogenesis and progression of atherosclerosis are integrally connected to the concentration and function of lipoproteins in various classes. This review examines existing and emerging approaches to modify low‐density lipoprotein and lipoprotein (a),
Rose Q Do, Stephen J Nicholls, Gregory G Schwartz   +2 more
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Flexible origin of hydrocarbon/pheromone precursors in Drosophila melanogaster[S]

Journal of Lipid Research, 2015
In terrestrial insects, cuticular hydrocarbons (CHCs) provide protection from desiccation. Specific CHCs can also act as pheromones, which are important for successful mating.
Claude Wicker-Thomas, Damien Garrido, Gwénaëlle Bontonou, Laura Napal, Nicolas Mazuras, Béatrice Denis, Thomas Rubin, Jean-Philippe Parvy, Jacques Montagne   +8 more
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Cholesterol substrate pools and steroid hormone levels are normal in the face of mutational inactivation of NPC1 protein

Journal of Lipid Research, 2006
Mutational inactivation of NPC1 largely blocks the movement of LDL-derived cholesterol from the lysosome to the metabolically active, cytosolic pool of sterol that is the substrate for steroid hormone production.
Chonglun Xie, James A. Richardson, Stephen D. Turley, John M. Dietschy   +3 more
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Lipolytic remnants of human VLDL produced in vitro: effect of HDL levels in the lipolysis mixtures on the apoCs to apoE ratio and metabolic properties of VLDL core remnants

Journal of Lipid Research, 2000
To determine the role of high-density lipoprotein (HDL) as an acceptor of lipolytic surface remnants of very low density lipoprotein (VLDL) in the metabolism of VLDL core remnants, we examined the effect of HDL levels in the VLDL lipolysis mixture on 1 ...
Byung Hong Chung, Nassrin Dashti
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Different mechanisms for selective transport of fatty acids using a single class of lipoprotein in Drosophila[S]

Journal of Lipid Research, 2019
In mammals, lipids are selectively transported to specific sites using multiple classes of lipoproteins. However, in Drosophila, a single class of lipoproteins, lipophorin, carries more than 95% of the lipids in the hemolymph.
Naoya Matsuo, Kohjiro Nagao, Takuto Suito, Naoto Juni, Utako Kato, Yuji Hara, Masato Umeda   +6 more
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Immunohistochemical Labeling of Low-Density Lipoprotein Receptor and Scavenger Receptor Class B Type 1 Are Increased in Canine Lymphoma

Frontiers in Veterinary Science, 2019
Altered lipid metabolism is a well-documented hallmark of neoplastic transformation and impacts disease progression. Two major lipoprotein receptors, the low-density lipoprotein receptor (LDL-R) and scavenger receptor class B, type 1 (SR-BI) are ...
Kristina Ceres, Halle Fitzgerald, Kathryn Shanelle Quiznon, Sean McDonough, Erica Behling-Kelly   +4 more
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A comparative study of surface binding of human low density and high density lipoproteins to human fibroblasts: regulation by sterols and susceptibility to proteolytic digestion

Journal of Lipid Research, 1977
Binding of 125I-low density lipoprotein (LDL) and 125I-high density lipoprotein (HDL) was determined in cultured human fibroblasts from a normal subject and two subjects with homozygous familial hypercholesterolemia (HFH). Binding was assayed at 0 ° C to
T Koschinsky, T E Carew, D Steinberg
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