Results 151 to 160 of about 6,206 (204)
Could Lipoxins Represent a New Standard in Ischemic Stroke Treatment?
International Journal of Molecular Sciences, 2021 Introduction: Cardiovascular diseases including stroke are one of the most common causes of death. Their main cause is atherosclerosis and chronic inflammation in the body.
Dariusz Kotlęga +2 more
exaly +2 more sources
Lipoxins: Potential anti-inflammatory, proresolution, and antifibrotic mediators in renal disease
Kidney International, 2004 Lipoxins: Potential anti-inflammatory, proresolution, and antifibrotic mediators in renal disease. Lipoxins are lipoxygenase-derived lipid mediators with both anti-inflammatory and proresolution properties that have been demonstrated in vivo and in vitro.
Paola Maderna, Catherine Godson
exaly +2 more sources
Lipoxins and synthetic lipoxin mimetics: Therapeutic potential in renal diseases
Biochimica Et Biophysica Acta - Molecular and Cell Biology of Lipids, 2021 Inflammation and its timely resolution are critical to ensuring effective host defence and appropriate tissue repair after injury. Unresolved inflammation typifies many renal pathologies. The key drivers of the inflammatory response are well defined and targeted by conventional anti-inflammatory therapeutics.
Darrell Andrews, Catherine Godson
exaly +3 more sources
Potential role of the lipoxygenase derived lipid mediators in atherosclerosis: leukotrienes, lipoxins and resolvins [PDF]
Clinical Chemistry and Laboratory Medicine, 2010 Atherogenesis is an inflammatory process with leukocytes infiltrating the arterial intima. The lipoxygenase pathways play a role in leukocyte recruitment through the generation of two classes of arachidonic acid lipid mediators, the leukotrienes and the ...
Martin Hersberger
exaly +2 more sources
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Clinical Hemorheology and Microcirculation, 2022
Lipoxins and ATL appear to be the first recognized members of a new class of endogenous mediator that are anti-inflammatory or serve for the “pro-resolution” of inflammation. PGE2 can and may display anti-inflammatory properties in certain settings, but in most cases, it enhances inflammation in vivo.
Shivani, Sachdeva +4 more
openaire +2 more sources
Lipoxins and ATL appear to be the first recognized members of a new class of endogenous mediator that are anti-inflammatory or serve for the “pro-resolution” of inflammation. PGE2 can and may display anti-inflammatory properties in certain settings, but in most cases, it enhances inflammation in vivo.
Shivani, Sachdeva +4 more
openaire +2 more sources
Lipoxins: revelations on resolution
Trends in Pharmacological Sciences, 2001Lipoxins (LXs) are endogenously produced eicosanoids typically generated during cell-cell interactions. In this article, the compelling evidence from in vitro and in vivo model systems that LXs actively promote the resolution of inflammation is reviewed. Of particular interest are indications that stable synthetic analogues of LXs and aspirin-triggered
Blaithin Mcmahon +2 more
exaly +3 more sources
Promising Anti-Inflammatory Tools: Biomedical Efficacy of Lipoxins and Their Synthetic Pathways
International Journal of Molecular Sciences, 2023 Lipoxins (LXs) have attracted widespread attention as a class of anti-inflammatory lipid mediators that are produced endogenously by the organism.
Wang Shang
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Conformational analysis of lipoxin A, lipoxin B and their trans-isomers
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1988Lipoxin A and lipoxin B (LXA and LXB) are formed from the oxygenation of arachidonic acid by interactions between the 5- and 15-lipoxygenases of human leukocytes. Each compound displays highly stereospecific biological actions. Here, we present a computational description of the following compounds: lipoxin A, (5S,6R,15S)-trihydroxy-7,9,13-trans-11-cis-
Brasseur, Robert +4 more
openaire +4 more sources