Results 161 to 170 of about 6,206 (204)
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Lipoxins and lipoxin analogs in asthma
Prostaglandins, Leukotrienes and Essential Fatty Acids, 2005The pathobiology of asthma is characterized by production of eicosanoids, a diverse family of bioactive fatty acids that play important roles in regulating airway inflammation and reactivity. Lipoxins (LXs) are products of arachidonic acid metabolism that are distinct from leukotrienes (LTs) and prostaglandins (PGs) in structure and function.
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Lipoxins and Aspirin-Triggered Lipoxins in Airway Responses
2003Here, we have demonstrated potent inhibition of allergen-mediated pulmonary inflammation and airway hyper-responsiveness by a novel dual-pronged action of LX's. Moreover, these results indicate that LX's play pivotal and previously unappreciated roles in regulating allergy and pulmonary inflammation.
Bruce D, Levy +8 more
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Lipoxin analogs and lipoxin formation in vivo
Prostaglandins, Leukotrienes and Essential Fatty Acids, 2005The definition of lipoxin bioactions in vivo and of lipoxin levels in humans, under physiological and pathological conditions, represents a main task toward the clinical use of lipoxins. The introduction of lipoxin stable analogs and of new methodology for immunological measurements of lipoxin A4 in human fluids is significantly contributing to fulfill
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Tetrahedron Letters, 1986
The synthesis of four isomers of 5.14,15-triHETE is reported. The key step is the coupling of acetylene 11 (or 19) with epoxide 7 to afford alcohol 12 (or 20). Natural lipoxin B is found to correspond to a mixture of 14R-8-cis-1, 14R-8-trans-3 and 14S-8-trans-4.
J, Morris, D G, Wishka
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The synthesis of four isomers of 5.14,15-triHETE is reported. The key step is the coupling of acetylene 11 (or 19) with epoxide 7 to afford alcohol 12 (or 20). Natural lipoxin B is found to correspond to a mixture of 14R-8-cis-1, 14R-8-trans-3 and 14S-8-trans-4.
J, Morris, D G, Wishka
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Prostaglandins, Leukotrienes and Essential Fatty Acids, 2005
Angiogenesis, the growth of new capillaries from pre-existing ones, occurs through dynamic functions of the endothelial cells (EC), including migration, proliferation and maturation, which are essential to achieve an organized formation of the vessel sprout.
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Angiogenesis, the growth of new capillaries from pre-existing ones, occurs through dynamic functions of the endothelial cells (EC), including migration, proliferation and maturation, which are essential to achieve an organized formation of the vessel sprout.
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The lipoxins: Determination of their biosynthesis
Pharmacological Research Communications, 1986The stereochemistry and double bond geometry of a novel series of leukocyte derived arachidonic acid metabolites, the lipoxins, was determined by comparison to pure unambiguous synthetic standards. The lipoxins were found to be a mixture of four lipoxin A isomers and two lipoxin B isomers.
J, Rokach +4 more
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Prostaglandins, Leukotrienes and Essential Fatty Acids, 2005
Dysregulated neutrophilic inflammation and chronic infection lead to progressive destruction of the airways in cystic fibrosis (CF). Despite considerable recent progress in therapy, the median survival of patients with CF remains around 30 years. The lipoxins are endogenous anti-inflammatory lipid mediators that are important regulators of neutrophilic
Christopher L, Karp +4 more
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Dysregulated neutrophilic inflammation and chronic infection lead to progressive destruction of the airways in cystic fibrosis (CF). Despite considerable recent progress in therapy, the median survival of patients with CF remains around 30 years. The lipoxins are endogenous anti-inflammatory lipid mediators that are important regulators of neutrophilic
Christopher L, Karp +4 more
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Lipoxins and aspirin-triggered lipoxins in neutrophil adhesion and signal transduction
Prostaglandins, Leukotrienes and Essential Fatty Acids, 2005Lipoxin A4 (LXA4) and aspirin-triggered 15-epi-LXA4 (ATL) are emerging as endogenous braking signals for neutrophil-mediated tissue injury. LXA4 and ATL and their metabolically stable analogues display potent inhibitory actions in human isolated cells and blood, including attenuation of expression of adhesion molecules on leukocytes and endothelial ...
János G, Filep +2 more
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The effects of lipoxin A and lipoxin B on functional responses of human granulocytes
Biochemical and Biophysical Research Communications, 1987Lipoxin A and lipoxin B (LXA and LXB) are formed from arachidonic acid by leukocyte 5- and 15-lipoxygenases. We have assessed the effects of synthetic lipoxins on functional responses of human granulocytes. LXA stimulated migration at 1 nM. The effect was highly stereospecific, since e.g. 6S-LXA and LXB were less active than LXA.
J, Palmblad +5 more
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Lipid Mediators: Lipoxin and Aspirin-Triggered 15-Epi-Lipoxins
Inflammation & Allergy-Drug Targets, 2006Lipoxins (LX) and their 15-epimers, aspirin triggered lipoxins (ATL) are emerging as major promoters of resolution of the inflammatory reaction. These eicosanoids, that carry a tetraene chromophore, derive from sequential lipoxygenase (LO) metabolism of arachidonic acid. Three principal routes of LX/ATL biosynthesis have been uncovered.
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