Results 171 to 180 of about 6,206 (204)

The Lipoxins: Synthesis and Biosynthesis

1988
Since the first report of their isolation in 19841,2 the lipoxins have generated considerable interest amongst researchers studying the lipoxygenase pathway. The interest has been due both to the novel structure and intreging pharmacological properties3,4,5 reported for these bio-molecules.
B, Fitzsimmons, J, Rokach
openaire   +2 more sources

Anti-inflammatory circuitry: Lipoxin, aspirin-triggered lipoxins and their receptor ALX

Prostaglandins, Leukotrienes and Essential Fatty Acids, 2005
Endogenous chemical mediators or autacoids play key roles in controlling inflammation and its programmed resolution. Among them, it is known that lipoxins (LX) and aspirin-triggered LX (ATL) evoke bioactions in a range of physiologic and pathophysiologic processes and serve as endogenous lipid/chemical mediators that stop neutrophilic infiltration and ...
Nan, Chiang, Makoto, Arita, Charles N, Serhan   +2 more
openaire   +2 more sources

Total synthesis of lipoxin A4 and lipoxin B4 from butadiene

Tetrahedron Letters, 2000
The total synthesis of LXA4 and LXB4 has been achieved starting from butadiene via palladium catalyzed telomerization. Sharpless catalytic AE and C-2 inversion of the 2(S),3(S)-epoxy alcohols, using Myers CO2/Cs2CO3 procedure, generated the asymmetric centers. The flexibility of the strategy allows an easy access to the linear eicosanoids.
Rodriguez, A, Nomen, M, Spur, B W, Godfroid, J J, Lee, T H   +4 more
openaire   +2 more sources

The Glomerular Physiology of Lipoxin-A

1988
A number of renal diseases, such as acute and chronic glomerulonephritis, acute interstitial nephritis, allograft rejection, and others are characterized by the presence inflammatory cellular infiltrates consisting, at various stages, of neutrophils, macrophages, monocytes, eosinophils, and lymphocytes.
openaire   +2 more sources

The lipoxins

International Journal of Biochemistry, 1988
J, Rokach, B, Fitzsimmons
openaire   +2 more sources

Lipoxin A4

1995
Lipoxins are a series of trihydroxylated derivatives of arachidonic acid formed by interaction of the 5- and 15-lipoxygenase pathways in human leukocytes. Lipoxin A4 is involved in the inflammatory process by inhibiting the cytotoxic activity of human natural killer cells and activating neutrophils.
openaire   +1 more source

Lipoxin A₄ and benzo-lipoxin A₄ attenuate experimental renal fibrosis.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2011
Unresolved inflammation underlies the development of fibrosis and organ failure. Here, we investigate the potential of the proresolving eicosanoid lipoxinA₄ (LXA₄) and its synthetic analog benzo-LXA₄ to prophylactically modulate fibrotic and inflammatory responses in a model of early renal fibrosis, unilateral ureteric obstruction (UUO).
Emma, Börgeson, Neil G, Docherty, Madeline, Murphy, Karen, Rodgers, Aidan, Ryan, Tim P, O'Sullivan, Patrick J, Guiry, Roel, Goldschmeding, Debra F, Higgins, Catherine, Godson   +9 more
openaire   +1 more source

Lipoxin

British Journal of Pharmacology, 2006
S P H Alexander, A Mathie, J A Peters
openaire   +1 more source

Lipoxins and their relationship with inflammation-associated diseases. A systematic review

Obesity Research and Clinical Practice, 2023
Herney Andres García‐Perdomo
exaly  

Lipoxins: nature's way to resolve inflammation

Journal of Inflammation Research, 2015
Neelam Sharma-Walia
exaly