Results 41 to 50 of about 26,671 (292)

Decellularised extracellular matrix-derived peptides from neural retina and retinal pigment epithelium enhance the expression of synaptic markers and light responsiveness of human pluripotent stem cell derived retinal organoids [PDF]

, 2019
Tissue specific extracellular matrices (ECM) provide structural support and enable access to molecular signals and metabolites, which are essential for directing stem cell renewal and differentiation.
Al-Aama, Jumana, Asfour, Hani Z., Ding, Yuchun, Doherty, Mary, Dorgau, Birthe, Felemban, Majed, Hallam, Dean, Hilgen, Gerrit, Hunt, Nicola Claire, Kiening, Martin, Krasnogor, Natalio, Lako, Majlinda, Sernagor, Evelyne, White, Kathryn, Whitfield, Phil, Zerti, Darin   +15 more
core   +2 more sources

E-cadherin can limit the transforming properties of activating β-catenin mutations [PDF]

, 2015
Wnt pathway deregulation is a common characteristic of many cancers. But only Colorectal Cancer predominantly harbours mutations in APC, whereas other cancer types (hepatocellular carcinoma, solid pseudopapillary tumours of pancreas) have activating ...
Alan R Clarke, Alastair Watson, Andrew D Campbell, Ann Hedley, Aoife Maguire, Brendan Doyle, David J Huels, Fatih Ceteci, Fei Song, Gabriela Kalna, Guenievre Moreaux, James Matthews, Karen R Reed, Lee Parry, Lionel Larue, Marc Leushacke, Nick Barker, Ola Söderberg, Owen J Sansom, Rachel A Ridgway, Runjan Chetty, Serra S, Simon Leedham, Sorina Radulescu, Sparks AB, Stefano Serra, Sujata Biswas, Valerie S Meniel   +27 more
core   +2 more sources

Liver Decellularization as Liver Organoid Reconstruction Scaffold

Buletin Farmatera, 2021
Abstrak Pendekatan terbaru dalam teknik rekayasa jaringan adalah penggunaan organ asal yang telah dideselularisasi sebagai scaffold (rangka) untuk rekonstruksi organ. Scaffold yang terbuat dari matriks alami ataupun sintetis memiliki banyak keterbatasan dalam memberikan mikrostruktur matriks ekstraseluler yang ideal untuk proliferasi dan ...
openaire   +2 more sources

Human liver organoids: From generation to applications

Hepatology, 2023
In the last decade, research into human hepatology has been revolutionized by the development of mini human livers in a dish. These liver organoids are formed by self-organizing stem cells and resemble their native counterparts in cellular content, multicellular architecture, and functional features. Liver organoids can be derived from the liver tissue
Afonso, Marta B, Marques, Vanda, van Mil, Saskia W C, Rodrigues, Cecilia M P   +3 more
openaire   +3 more sources

Scalable production of tissue-like vascularized liver organoids from human PSCs

Experimental and Molecular Medicine, 2023
The lack of physiological parity between 2D cell culture and in vivo culture has led to the development of more organotypic models, such as organoids. Organoid models have been developed for a number of tissues, including the liver.
Sean P. Harrison, Richard Siller, Yoshiaki Tanaka, Maria Eugenia Chollet, María Eugenia de la Morena-Barrio, Yangfei Xiang, Benjamin Patterson, Elisabeth Andersen, Carlos Bravo-Pérez, Henning Kempf, Kathrine S. Åsrud, Oleg Lunov, Alexandr Dejneka, Marie-Christine Mowinckel, Benedicte Stavik, Per Morten Sandset, Espen Melum, Saphira Baumgarten, Flavio Bonanini, Dorota Kurek, Santosh Mathapati, Runar Almaas, Kulbhushan Sharma, Steven R. Wilson, Frøydis S. Skottvoll, Ida C. Boger, Inger Lise Bogen, Tuula A. Nyman, Jun Jie Wu, Ales Bezrouk, Dana Cizkova, Javier Corral, Jaroslav Mokry, Robert Zweigerdt, In-Hyun Park, Gareth J. Sullivan   +35 more
doaj   +1 more source

A 3-D in vitro co-culture model of mammary gland involution. [PDF]

, 2014
Involution is a process whereby the mammary gland undergoes extensive tissue remodelling involving exquisitely coordinated cell death, extracellular matrix degradation and adipose tissue regeneration following the weaning of offspring.
Botos, Laur-Alexandru, Cameron, Ruth E., Campbell, Jonathan J., Davidenko, Natalia, Sargeant, Timothy J., Watson, Christine J.   +5 more
core   +3 more sources

The organoid-initiating cells in mouse pancreas and liver are phenotypically and functionally similar

Stem Cell Research, 2014
Pancreatic Lgr5 expression has been associated with organoid-forming epithelial progenitor populations but the identity of the organoid-initiating epithelial cell subpopulation has remained elusive.
Craig Dorrell, Branden Tarlow, Yuhan Wang, Pamela S. Canaday, Annelise Haft, Jonathan Schug, Philip R. Streeter, Milton J. Finegold, Lincoln T. Shenje, Klaus H. Kaestner, Markus Grompe   +10 more
doaj   +1 more source

Cornea organoids from human induced pluripotent stem cells. [PDF]

, 2017
The cornea is the transparent outermost surface of the eye, consisting of a stratified epithelium, a collagenous stroma and an innermost single-cell layered endothelium and providing 2/3 of the refractive power of the eye. Multiple diseases of the cornea
Adams, Sheila M, Birk, David E, Chakravarti, Shukti, Foster, James W, Wahlin, Karl, Zack, Donald J   +5 more
core   +3 more sources

Liver organoids: Current advances and future applications for hepatology [PDF]

Clinical and Molecular Hepatology
The creation of self-organizing liver organoids represents a significant, although modest, step toward addressing the ongoing organ shortage crisis in allogeneic liver transplantation.
Yohan Kim, Minseok Kang, Michael Girma Mamo, Michael Adisasmita, Meritxell Huch, Dongho Choi   +5 more
doaj   +1 more source

Opposing effects of TIGAR- and RAC1-derived ROS on Wnt-driven proliferation in the mouse intestine [PDF]

, 2016
Reactive oxygen species (ROS) participate in numerous cell responses, including proliferation, DNA damage, and cell death. Based on these disparate activities, both promotion and inhibition of ROS have been proposed for cancer therapy.
Blyth, Karen, Ceteci, Fatih, Cheung, Eric, Lee, Pearl, Nixon, Colin, Sansom, Owen, Vousden, Karen   +6 more
core   +1 more source