Results 231 to 240 of about 23,262 (271)
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Advances in liver organoids: model systems for liver disease
Archives of Pharmacal Research, 2022Reliable in vitro models with human-derived cells that recapitulate in vivo-like physiologies are required for drug discovery and development to reduce the gap between the results of cell-based drug testing, animal testing, and human clinical trials. Liver organoid models have emerged as novel tools for hepatotoxicity evaluation, liver disease modeling,
Jaeseo Lee +4 more
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Organoids for Liver Stage Malaria Research
Trends in Parasitology, 2020Plasmodium parasites cause malaria and are maintained between Anopheles mosquitoes and mammalian hosts in a complex life cycle. Malaria parasites occupy tissue niches that can be difficult to access, and models to study them can be challenging to recapitulate experimentally, particularly for Plasmodium species that infect humans.
Ronan, Mellin, Justin A, Boddey
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Liver Organoids: Formation Strategies and Biomedical Applications
Tissue Engineering and Regenerative Medicine, 2021The liver is the most important digestive organ in the body. Several studies have explored liver biology and diseases related to the liver. However, most of these studies have only explored liver development, mechanism of liver regeneration and pathophysiology of liver diseases mainly based on two-dimensional (2D) cell lines and animal models ...
Xinglong Zhu +3 more
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Ethical challenges for pediatric liver organoid transplantation
Science Translational Medicine, 2020The authors discuss whether it is ethically acceptable to include children in a first-in-human clinical trial of liver organoid transplantation.
Sarah A. Schneemann +5 more
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2017
The development of novel and consistent biologic surrogates for drug discovery, toxicology, and cancer research is presently intense and involves a growing number of research groups and institutions around the world. The Twilight of the days of immortalized cell lines as the workhorse of most of our drug development and cancer research efforts seem now
Estela Solanas +6 more
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The development of novel and consistent biologic surrogates for drug discovery, toxicology, and cancer research is presently intense and involves a growing number of research groups and institutions around the world. The Twilight of the days of immortalized cell lines as the workhorse of most of our drug development and cancer research efforts seem now
Estela Solanas +6 more
openaire +1 more source
Journal of Hepatology
BACKGROUND & AIMS Alcohol-associated liver disease (ALD) is a major cause of liver disease worldwide with scarce therapeutic options. Animal models poorly recapitulate advanced ALD precluding the development of new treatments. Organoids have emerged as a
S. Ariño +25 more
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BACKGROUND & AIMS Alcohol-associated liver disease (ALD) is a major cause of liver disease worldwide with scarce therapeutic options. Animal models poorly recapitulate advanced ALD precluding the development of new treatments. Organoids have emerged as a
S. Ariño +25 more
semanticscholar +1 more source
Polystyrene microplastics induce hepatotoxicity and disrupt lipid metabolism in the liver organoids.
Science of the Total Environment, 2021Microplastic particles (MP) has been detected in the environment widespread. Human beings are inevitably exposed to MP via multiple routines. However, the hazard identifications, as direct evidence of exposure and health risk, have not been fully ...
Wei Cheng +9 more
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Environment International
Ageing is a nature process of microplastics that occurrs daily, and human beings are inevitably exposed to aged microplastics. However, a systematic understanding of ageing status and its toxic effect is currently still lacking.
Wei Cheng +7 more
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Ageing is a nature process of microplastics that occurrs daily, and human beings are inevitably exposed to aged microplastics. However, a systematic understanding of ageing status and its toxic effect is currently still lacking.
Wei Cheng +7 more
semanticscholar +1 more source
The iron matters: Aged microplastics disrupted the iron homeostasis in the liver organoids.
Science of the Total Environment, 2023Plastic products undergo artificial and unintentional aging during daily use, causing the presence of aged microplastics (aMP). Humans are inevitably exposed to aMP.
Wei Cheng +7 more
semanticscholar +1 more source
Transcriptome-Guided Design of Physiological Multilineage Liver Organoids
Trends in Genetics, 2021Despite several technical challenges, human induced pluripotent stem cell (hiPSC)-derived organoids enable biologically and clinically relevant functional study of physiology and disease. In a recent Cell Systems article, Velazquez et al. report a novel strategy to identify regulators of multilineage organoid maturation by reverse-engineering from the ...
Zhu, Shijia +2 more
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