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KCNQ1OT1: An Oncogenic Long Noncoding RNA [PDF]

open access: yesBiomolecules, 2021
Long noncoding RNAs (lncRNAs) are transcripts greater than 200 nucleotides that do not code for proteins but regulate gene expression. Recent studies indicate that lncRNAs are involved in the modulation of biological functions in human disease.
Patrice Cagle   +3 more
doaj   +3 more sources

Neuroprotective effects of long noncoding RNAs involved in ischemic postconditioning after ischemic stroke

open access: yesNeural Regeneration Research, 2022
During acute reperfusion, the expression profiles of long noncoding RNAs in adult rats with focal cerebral ischemia undergo broad changes. However, whether long noncoding RNAs are involved in neuroprotective effects following focal ischemic stroke in ...
Wei Ma   +14 more
doaj   +1 more source

The Long Noncoding RNA Gm9866/Nuclear Factor-κB Axis Promotes Macrophage Polarization

open access: yesMediators of Inflammation, 2023
Macrophages are a type of immune cells with high levels of plasticity and heterogeneity. They can polarize into M1 or M2 functional phenotypes. These two phenotypes exhibit a dynamic balance during polarization-related diseases and play opposing roles ...
Xiaomin Liao   +9 more
doaj   +1 more source

The Landscape of Noncoding RNA in Pulmonary Hypertension

open access: yesBiomolecules, 2022
The transcriptome of pulmonary hypertension (PH) is complex and highly genetically heterogeneous, with noncoding RNA transcripts playing crucial roles.
Lin Deng   +4 more
doaj   +1 more source

Long Noncoding RNA Maternally Expressed Gene 3 Is Downregulated, and Its Insufficiency Correlates With Poor-Risk Stratification, Worse Treatment Response, as Well as Unfavorable Survival Data in Patients With Acute Myeloid Leukemia

open access: yesTechnology in Cancer Research & Treatment, 2020
Objective: Our study aimed to investigate the correlation of long noncoding RNA maternally expressed gene 3 expression with clinical features, treatment response, and survival profiles in patients with acute myeloid leukemia. Methods: Bone marrow samples
Chunling He MM   +4 more
doaj   +1 more source

Non‐coding RNA and cholesteatoma

open access: yesLaryngoscope Investigative Otolaryngology, 2022
Objective Cholesteatoma is a challenging chronic pathology of the middle ear for which pharmacologic therapies have not been developed yet. Cholesteatoma occurrence depends on the interplay between genetic and environmental factors while master ...
Ivan Jovanovic   +3 more
doaj   +1 more source

Long noncoding RNA study: Genome-wide approaches

open access: yesGenes and Diseases, 2023
Long noncoding RNAs (lncRNAs) have been confirmed to play a crucial role in various biological processes across several species. Though many efforts have been devoted to the expansion of the lncRNAs landscape, much about lncRNAs is still unknown due to ...
Shuang Tao   +6 more
doaj   +1 more source

Knockdown of lncRNA OGFRP1 Inhibits Proliferation and Invasion of JEG-3 Cells Via AKT/mTOR Pathway

open access: yesTechnology in Cancer Research & Treatment, 2020
Increasing evidence indicates the pivotal role of long noncoding RNAs in a variety of cancers, but there is limited focus on the link between long noncoding RNAs and gestational choriocarcinoma.
Qian Meng BD, Haiyan Xue MD
doaj   +1 more source

Long Noncoding RNA LUCAT1 Promotes Multiple Myeloma Cell Growth by Regulating the TGF-β Signaling Pathway

open access: yesTechnology in Cancer Research & Treatment, 2020
Objective: Long noncoding RNAs (lncRNAs) are potential biomarkers for cancers. Nevertheless, the ability of long noncoding RNA lung cancer-associated transcript 1 in patients with multiple myeloma remains unknown. The purpose of this current study was to
Zhaoyu Liu MM   +3 more
doaj   +1 more source

Dysregulation of lncRNAs in circulation of patients with periodontitis: results of a pilot study

open access: yesBMC Oral Health, 2021
Background Periodontitis is a chronic inflammatory disorder with a complex etiology. Long non-coding RNAs (lncRNAs) have been shown to affect pathoetiology of periodontitis.
Soudeh Ghafouri-Fard   +7 more
doaj   +1 more source

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