Results 201 to 210 of about 713,910 (249)

In Situ Photo‑Crosslinked Functional Bilayer Hydrogel Modulates Local Microenvironment and Remyelination After Optic Nerve Injury

Advanced Science, EarlyView.
A blue‐light‐crosslinked bilayer hydrogel was developed for local optic nerve repair. The adhesive GM‐Odex outer layer seals and anchors the lesion, while the non‐adhesive GM‐imid inner layer releases MPDA‐Cle without obstructing CSF flow. This system modulates oxidative and inflammatory microenvironments, supports oligodendrocyte differentiation and ...
Tonghe Pan, Yate Huang, Junhao Zhang, Shudong Tian, Zhixing Li, Xuanwen Li, Yanchen Zhang, Dongmei Wang, Sihao Ye, Ming Jin, Neng Ling, Wentao Yan, Kaihui Nan, Wencan Wu   +13 more
wiley   +1 more source

A Neutrophil Membrane‐Encapsulated Pd/hCeO2 Nanoformulation for Alleviating Age‐Dependent Perioperative Neurocognitive Disorders

Advanced Science, EarlyView.
This study reports a neutrophil membrane‐encapsulated Pd/hCeO2 nanozyme (PCN) for targeted treatment of perioperative neurocognitive disorders (PND) in aged mice. PCN inhibits glycolysis‐driven microglial activation and neuroinflammation, improves mitochondrial respiration, and maintains blood‐brain barrier integrity and synaptic function, ultimately ...
Lili Huang, Jiahui Cheng, Huan Xu, Qiang Zhang, Xiao Zhang, Ye Liu, Yizhe Zhang, Wanbing Dai, Zhi Xiong, Linghuan Guo, Lingling Xu, Wen Wang, Xin Xu, Yan Zhou, Weifeng Yu, Bo Li, Diansan Su, Daxiang Wen   +17 more
wiley   +1 more source

All eukaryotic SMC proteins induce a twist of -0.6 at each DNA loop extrusion step. [PDF]

Sci Adv
Janissen R, Barth R, Davidson IF, Peters JM, Dekker C.   +4 more
europepmc   +1 more source

Sea Cucumber‐Inspired Double‐Network Biopolymer Hydrogels for Programmable Soft Machines

Advanced Science, EarlyView.
Inspired by the mutable dermis of sea cucumbers, the collagen‐alginate double‐network elastomeric (CoDE) hydrogel achieves programmable, recoverable, and functional mechanical behavior. The CoDE hydrogel mimics the mutable stiffness of the sea cucumber dermis through a densified collagen cryogel scaffold that is secondarily reinforced by a dissipative,
Luo Yan, He Xiao, Purohit Prashant K., Vining Kyle H.   +3 more
wiley   +1 more source

Beyond genomic weaving: molecular roles for CTCF outside cohesin loop extrusion. [PDF]

Curr Opin Genet Dev
Corin A, Nora EP, Ramani V.
europepmc   +1 more source

H4K12 Lactylation Regulates NDUFS7 to Drive Microglia Reverse Electron Transport in Spinal Cord Injury

Advanced Science, EarlyView.
Lactate accumulation after SCI promotes H4K12la lactylation, which upregulates NDUFS7, triggering mitochondrial RET and ROS, enforcing pro‐inflammatory microglial polarization. MM@mPTC, a biomimetic nanotherapeutic, degrades LDHA in activated microglia, reducing H4K12la lactylation and blocking RET, thus curbing ROS, fostering a reparative phenotype ...
Chenglong Hong, Zhichen Jiang, Zhouwei Wu, Chenyu Wu, Jiang Liu, Kaijie Guo, Yihui Liang, Shaobo Xu, Yuchen Jin, Yong Xiao, Lei Guo, Hui Xu, Sunren Sheng, Chenggui Wang   +13 more
wiley   +1 more source

Self‐Responsive Plastron Maintenance on a Superhydrophobic Mesh via Locally Integrated Electrolysis

Advanced Science, EarlyView.
This work presents a self‐switchable SHM‐E surface that enables rapid, autonomous plastron self‐repair and long‐term stability. Plastron loss triggers circuit closure and localized electrolysis, while capillary spreading rapidly restores a continuous plastron and self‐terminates the current.
Jiaming Wang, Zhen Zhang, Yuhong Liu
wiley   +1 more source

Molecular dynamics simulations of human cohesin subunits identify DNA binding sites and their potential roles in DNA loop extrusion. [PDF]

PLoS Comput Biol
Gu C, Takada S, Brandani GB, Terakawa T.
europepmc   +1 more source

3D Bioprinted Blood–Brain–Tumor Barrier Spheroid‐Based In Situ Evaluation of Anticancer Compounds Against Glioblastoma: ROS‐Producing Ruthenium as a Potential Therapeutic Candidate

Advanced Science, EarlyView.
The blood–brain–tumor barrier (BBTB) penetration by anticancer drugs and their effects on glioblastoma (GBM) is assessed using 3D bioprinted‐spheroids. Anticancer drug‐induced U‐87 MG cell death is quantified through in situ imaging of spheroids using a cancer cell death probe. The Ru compound, a partial P‐gp substrate, induces greater tumor‐cell death
Hyunjung Lee, Chan Ho Jeon, Doyun Kim, Minjae Lee, Minji Kwon, Joon Myong Song   +5 more
wiley   +1 more source

Stretchable h‐BN/TPU Fibers for Passive‐Active Dual‐Mode Thermal Management and Wearable Haptic Interfaces

Advanced Science, EarlyView.
Optimized 30 wt.% h‐BN/TPU fibers create a thermal conductivity of 2.08 W·m−1·K−1 while retaining mechanical compliance (422% elongation at break). Woven fabrics reduce surface temperature by 5.7°C under simulated solar irradiation. Glove integration enables localized fingertip heating at 29.55°C·s−1 with a thermal relaxation time of approximately 20 s.
Yiwei Zhou, Shanshan Long, Bo Chen, Maohua Li, Linhong Li, Yue Qin, Rongjie Yang, Hanxi Chen, Cheng‐Te Lin, Yixiang Xu, Kean How Cheah, Nan Jiang, Jinhong Yu   +12 more
wiley   +1 more source