Results 221 to 230 of about 713,910 (249)

CircFAM65A/CANX Condensates Sequester FAM134B to Inhibit ER‐phagy and Suppress Hepatocellular Carcinoma Progression

Advanced Science, EarlyView.
The novel circRNA circFAM65A suppresses HCC progression. Mechanistically, circFAM65A drives CANX phase separation, which recruits FAM134B into condensates and blocks its interaction with LC3, thereby inhibiting ER‐phagy and HCC progression. Importantly, targeted circFAM65A delivery represents a potential therapeutic strategy for HCC.
Wenxiu Ru, Lunbiao Gan, Yu Lu, Yujing Guo, Qian Huang, Sha Yin, Fengze Nie, Sijia Di, Jiaqi Ning, Siyu Yao, Huanhuan Wan, Le Liu, Zehua Liu, Fa Yang, Weijun Qin, Weihong Wen   +15 more
wiley   +1 more source

Intelligent Polymer Electrolytes for Next‐Generation Zinc‐Based Energy Storage Devices

Advanced Science, EarlyView.
Intelligent polymer electrolytes are organized into a three‐level hierarchy that advances zinc‐based energy storage from passive ion conduction toward active, adaptive, and intelligent operation. Molecular regulation of Zn+ coordination, water activity, desolvation, ion flux, and interfaces underpins adaptive self‐healing, anti‐freezing, adhesion, and ...
Sanath Kumar, Jhansirani Kesavan, Muhammad Asim, Atul Verma, Yen‐Pei Fu   +4 more
wiley   +1 more source

Beyond Charge: Field‐Effect Transistors in Multimodal Biosensing Platforms for Biomolecular Interaction Studies

Advanced Electronic Materials, EarlyView.
This review summarizes the developments in field‐effect transistor (FET)‐based dual‐mode sensor platforms and what can be learned from them. It identifies charge as a crucial factor in biomolecular interactions at interfaces, outlines the challenges of hybrid systems, and highlights their benefits.
Roger Hasler, Ciril Reiner‐Rozman, Christoph Kleber, Jakub Dostalek, Wolfgang Knoll   +4 more
wiley   +1 more source

Attraction and disruption: how loop extrusion and compartmentalisation shape the nuclear genome.

Curr Opin Genet Dev
Magnitov M, de Wit E.
europepmc   +1 more source

Condensin loop extrusion properties, roadblocks, and role in homology search in S. cerevisiae

Piveteau V, Dupont C, Salari H, Dumont A, Savocco J, Jost D, Piazza A.   +6 more
europepmc   +1 more source

MDA5 generates compact ribonucleoprotein complexes via ATP-dependent single-stranded RNA loop extrusion

Quack S, Maity S, America PPB, Klein M, del Valle AH, Singh R, Smitskamp Q, Papini FS, Broedersz CP, Roos WH, Modis Y, Dulin D.   +11 more
europepmc   +1 more source

RNA Polymerases as Moving Barriers to Condensin Loop Extrusion [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 2019
To separate replicated sister chromatids during mitosis, eukaryotes and prokaryotes have structural maintenance of chromosome (SMC) condensin complexes that were recently shown to organize chromosomes by a process known as DNA loop extrusion.
Hugo B Brandão, Xindan Wang, Payel Paul
exaly   +6 more sources

Extrusion Without a Motor: A New Take on the Loop Extrusion Model of Genome Organization [PDF]

Nucleus, 2018
Chromatin loop extrusion is a popular model for the formation of CTCF loops and topological domains. Recent HiC data have revealed a strong bias in favour of a particular arrangement of the CTCF binding motifs that stabilize loops, and extrusion is the only model to date which can explain this. However, the model requires a motor to generate the loops,
Chris A. Brackley, Peter R Cook, Mario Nicodemi   +2 more
exaly   +7 more sources

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Loop extrusion rules: the next generation

Current Opinion in Genetics & Development, 2023
The interphase genome of vertebrates contains roughly 100 000 dynamic loops formed by cohesins. These loops are thought to play important roles in many functions, but their exact contribution in each case remains hotly disputed. The key challenge in studying these loops is the lack of a single experimental technique that could reliably and ...
Flavia Corsi, Emma Rusch, Anton Goloborodko   +2 more
openaire   +2 more sources

Regulation of loop extrusion on the interphase genome

Critical Reviews in Biochemistry and Molecular Biology, 2023
In the human cell nucleus, dynamically organized chromatin is the substrate for gene regulation, DNA replication, and repair. A central mechanism of DNA loop formation is an ATPase motor cohesin-mediated loop extrusion. The cohesin complexes load and unload onto the chromosome under the control of other regulators that physically interact and affect ...
Shin, Hyogyung, Kim, Yoori
openaire   +3 more sources