Results 221 to 230 of about 18,925 (244)

Enhanced strategies for cuproptosis‐like death in bacterial infection treatment

BMEMat, EarlyView.
This review summarizes and examines the molecular mechanisms underlying cuproptosis‐like death. Furthermore, multi‐strategy efficacy enhancement and potential enhancement approaches are analyzed. Abstract Copper, a classical antibacterial metal, has long been of interest and widely used in medical and public health applications.
Wenqi Wang, Bolong Xu, Ruiyuan Zhu, Hengshuo Gui, Tian Xia, Shaokai Liu, Huiyu Liu, Xianwen Wang   +7 more
wiley   +1 more source

Implementation of Machine Learning Models to Predict Functionality of Pea Flour From Its Composition

Cereal Chemistry, EarlyView.
ABSTRACT Background and Objectives The goal of this research was to examine the relationship between the composition and functionality of pea flour using the following machine learning algorithms: linear regression, partial least squares regression (PLSR), Gaussian process regression (GPR), support vector regression, gradient‐boosted decision trees ...
Colten N. Nickerson, Sarah Hogarth, Andrea K. Stone, Gene C. Arganosa, Pankaj Bhowmik, Tom D. Warkentin, Jordan Ubbens, Michael T. Nickerson   +7 more
wiley   +1 more source

MDA5 generates compact ribonucleoprotein complexes via ATP-dependent single-stranded RNA loop extrusion

Quack S, Maity S, America PPB, Klein M, del Valle AH, Singh R, Smitskamp Q, Papini FS, Broedersz CP, Roos WH, Modis Y, Dulin D.   +11 more
europepmc   +1 more source

Extrusion without a motor: a new take on the loop extrusion model of genome organization [PDF]

Nucleus, 2018
Chromatin loop extrusion is a popular model for the formation of CTCF loops and topological domains. Recent HiC data have revealed a strong bias in favour of a particular arrangement of the CTCF binding motifs that stabilize loops, and extrusion is the ...
Chris A Brackley, Davide Michieletto, Mario Nicodemi   +2 more
exaly   +8 more sources

RNA polymerases as moving barriers to condensin loop extrusion [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 2019
To separate replicated sister chromatids during mitosis, eukaryotes and prokaryotes have structural maintenance of chromosome (SMC) condensin complexes that were recently shown to organize chromosomes by a process known as DNA loop extrusion.
Hugo B Brandao, Payel Paul, Aafke A Van Den Berg   +2 more
exaly   +5 more sources

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Loop extrusion rules: the next generation

Current Opinion in Genetics & Development, 2023
The interphase genome of vertebrates contains roughly 100 000 dynamic loops formed by cohesins. These loops are thought to play important roles in many functions, but their exact contribution in each case remains hotly disputed. The key challenge in studying these loops is the lack of a single experimental technique that could reliably and ...
Flavia Corsi, Emma Rusch, Anton Goloborodko   +2 more
openaire   +2 more sources

Regulation of loop extrusion on the interphase genome

Critical Reviews in Biochemistry and Molecular Biology, 2023
In the human cell nucleus, dynamically organized chromatin is the substrate for gene regulation, DNA replication, and repair. A central mechanism of DNA loop formation is an ATPase motor cohesin-mediated loop extrusion. The cohesin complexes load and unload onto the chromosome under the control of other regulators that physically interact and affect ...
Shin, Hyogyung, Kim, Yoori
openaire   +3 more sources

Chromatin jets define the properties of cohesin-driven in vivo loop extrusion [PDF]

Molecular Cell, 2022
Complex genomes show intricate organization in three-dimensional (3D) nuclear space. Current models posit that cohesin extrudes loops to form self-interacting domains delimited by the DNA binding protein CTCF.
King, James WD, Al-Jibury, Ediem, Fisher, Amanda G., Merkenschlager, Matthias, Pruessner, Gunnar, Garcia-Millan, Rosalba, King, James W.D., Guo, Ya, Ntagiantas, Konstantinos, Lenhard, Boris, Nash, Alex J., Galjart, Niels; id_orcid, Galjart, Niels, Fisher, Amanda G, Rueckert, Daniel, Nash, Alex J   +15 more
exaly   +2 more sources

Genome folding through loop extrusion by SMC complexes

Nature Reviews Molecular Cell Biology, 2021
Genomic DNA is folded into loops and topologically associating domains (TADs), which serve important structural and regulatory roles. It has been proposed that these genomic structures are formed by a loop extrusion process, which is mediated by structural maintenance of chromosomes (SMC) protein complexes.
Iain F Davidson, Jan-Michaél Peters, Peters Jan-Michaél   +2 more
exaly   +3 more sources

Loop extrusion promotes an alternate pathway for isotype switching [PDF]

Cell Reports, 2021
Class-switch recombination (CSR) involves replacement of the Cμ constant region with another downstream CH region. CSR is initiated by activation-induced cytidine deaminase (AID)-mediated DNA breaks that are targeted to transcriptionally active switch (S) regions.
Hong Ming Shen, Robert Wuerffel, Xue Lei   +2 more
exaly   +3 more sources