Results 11 to 20 of about 419 (198)
Cells, 2023 While the suprachiasmatic nucleus (SCN) coordinates many daily rhythms, some circadian patterns of expression are controlled by SCN-independent systems. These include responses to daily methamphetamine (MAP) injections.
Riku Sato +11 more
doaj +1 more source
Luciferins Behave Like Drugs [PDF]
ACS Chemical Neuroscience, 2015 The light emission chemistry of firefly luciferase can be harnessed to reveal otherwise invisible biological processes occurring in the brains of live animals. Though powerful, the need for the luciferase substrate D-luciferin to traverse the blood-brain barrier poses limitations on the sensitivity and interpretation of these experiments.
Mofford, David M., Miller, Stephen C.
openaire +3 more sources
Structure-Functional Analysis of Human Cytochrome P450 2C8 Using Directed Evolution
Pharmaceutics, 2021 The human genome includes four cytochrome P450 2C subfamily enzymes, and CYP2C8 has generated research interest because it is subject to drug–drug interactions and various polymorphic outcomes.
Rowoon Lee +3 more
doaj +1 more source
Luciferins Under Construction: A Review of Known Biosynthetic Pathways
Frontiers in Ecology and Evolution, 2021 Bioluminescence, or the ability of a living organism to generate visible light, occurs as a result of biochemical reaction where enzyme, known as a luciferase, catalyzes the oxidation of a small-molecule substrate, known as luciferin.
Aleksandra S. Tsarkova +1 more
doaj +1 more source
Nature Communications, 2016 D-luciferin is the standard bioluminescent substrate for in vitro and in vivo imaging. Here the authors introduce AkaLumine-HCl, a soluble luciferin analogue with a near-infrared emission maximum, which allows deep tissue imaging at lower concentrations ...
Takahiro Kuchimaru +7 more
doaj +1 more source
Bioluminescence-Driven Optogenetics
Life, 2020 Bioluminescence-based technologies are among the most commonly used methods to quantify and visualise physiology at the cellular and organismal levels.
Macià Sureda-Vives, Karen S. Sarkisyan
doaj +1 more source
Electrochemically Generated Luminescence of Luminol and Luciferin in Ionic Liquids
ChemElectroChem, 2023 Electrochemiluminescence (ECL) is the generation of light triggered by an electrochemical reaction. ECL has been extensively studied in solvent‐based electrolytes, but there is a lack of data on using electrode reactions to populate an excited‐state ...
Mattia Belotti +4 more
doaj +1 more source
Synthesis of N-peptide-6-amino-D-luciferin Conjugates
Frontiers in Chemistry, 2018 A general strategy for the synthesis of N-peptide-6-amino-D-luciferin conjugates has been developed. The applicability of the strategy was demonstrated with the preparation of a known substrate, N-Z-Asp-Glu-Val-Asp-6-amino-D-luciferin (N-Z-DEVD-aLuc).
Anita K. Kovács +8 more
doaj +1 more source
Molecular Imaging, 2016 Cyclodextrins are well-characterized, barrel-shaped molecules that can solubilize organic small molecules in aqueous solution via host–guest interactions. As such, cyclodextrins are used as excipients for experimental therapeutics in vivo.
Jeyan S. Kumar MSc +3 more
doaj +1 more source
Isolation of Taxol and Flavin-like fluorochrome from Endophytic Fungi of Mangifera indica
Journal of Pure and Applied Microbiology, 2021 Scouting for novel and plant-derived biomolecules from endophytic microbial sources draws greater focus on the discovery of novel bioactive metabolites.
Enthai Ganeshan Jagan +3 more
doaj +1 more source