Results 21 to 30 of about 67,421 (349)
Luciferins Behave Like Drugs [PDF]
ACS Chemical Neuroscience, 2015 The light emission chemistry of firefly luciferase can be harnessed to reveal otherwise invisible biological processes occurring in the brains of live animals. Though powerful, the need for the luciferase substrate D-luciferin to traverse the blood-brain barrier poses limitations on the sensitivity and interpretation of these experiments.
Mofford, David M., Miller, Stephen C.
openaire +3 more sources
Structure-Functional Analysis of Human Cytochrome P450 2C8 Using Directed Evolution
Pharmaceutics, 2021 The human genome includes four cytochrome P450 2C subfamily enzymes, and CYP2C8 has generated research interest because it is subject to drug–drug interactions and various polymorphic outcomes.
Rowoon Lee +3 more
doaj +1 more source
Scientific Reports, 2020 Larvae of O. fultoni (Keroplatidae: Keroplatinae), which occur along river banks in the Appalachian Mountains in Eastern United States, produce the bluest bioluminescence among insects from translucent areas associated to black bodies, which are located ...
V. Viviani +6 more
semanticscholar +1 more source
International Journal of Molecular Sciences, 2020 Bioluminescence imaging (BLI) is useful to monitor cell movement and gene expression in live animals. However, D-luciferin has a short wavelength (560 nm) which is absorbed by tissues and the use of near-infrared (NIR) luciferin analogues enable high ...
J. Nakayama +7 more
semanticscholar +1 more source
Molecular Imaging and Biology, 2020 Currently, a variety of red and green beetle luciferase variants are available for bioluminescence imaging (BLI). In addition, new luciferin analogues providing longer wavelength luminescence have been developed that show promise for improved deep tissue
Giorgia Zambito +8 more
semanticscholar +1 more source
Convergent synthesis and optical properties of near-infrared emitting bioluminescent infra-luciferins [PDF]
, 2016 Infra-luciferin, an alkene linked analogue of luciferin, gives bioluminescence emission >700 nm and has the potential to be used for multiparametric in vivo imaging.
Anderson, James C. +5 more
core +4 more sources
Luciferins Under Construction: A Review of Known Biosynthetic Pathways
Frontiers in Ecology and Evolution, 2021 Bioluminescence, or the ability of a living organism to generate visible light, occurs as a result of biochemical reaction where enzyme, known as a luciferase, catalyzes the oxidation of a small-molecule substrate, known as luciferin.
Aleksandra S. Tsarkova +1 more
doaj +1 more source
Recent Progress in Optical Sensors for Biomedical Diagnostics [PDF]
, 2020 In recent years, several types of optical sensors have been probed for their aptitude in healthcare biosensing, making their applications in biomedical diagnostics a rapidly evolving subject.
Altintas, Zeynep, Pirzada, Muqsit
core +1 more source
Chirality, 2020 Interestingly, only the D‐form of firefly luciferin produces light by luciferin–luciferase (L–L) reaction. Certain firefly luciferin analogues with modified structures maintain bioluminescence (BL) activity; however, all L‐form luciferin analogues show ...
Nobuo Kitada +7 more
semanticscholar +1 more source
Bioluminescence-Driven Optogenetics
Life, 2020 Bioluminescence-based technologies are among the most commonly used methods to quantify and visualise physiology at the cellular and organismal levels.
Macià Sureda-Vives, Karen S. Sarkisyan
doaj +1 more source