Results 21 to 30 of about 44,149 (263)

Luciferins Behave Like Drugs [PDF]

ACS Chemical Neuroscience, 2015
The light emission chemistry of firefly luciferase can be harnessed to reveal otherwise invisible biological processes occurring in the brains of live animals. Though powerful, the need for the luciferase substrate D-luciferin to traverse the blood-brain barrier poses limitations on the sensitivity and interpretation of these experiments.
Mofford, David M., Miller, Stephen C.
openaire   +3 more sources

The Drug Excipient Cyclodextrin Interacts With -Luciferin and Interferes With Bioluminescence Imaging

Molecular Imaging, 2016
Cyclodextrins are well-characterized, barrel-shaped molecules that can solubilize organic small molecules in aqueous solution via host–guest interactions. As such, cyclodextrins are used as excipients for experimental therapeutics in vivo.
Jeyan S. Kumar MSc, Lisa M. Miller Jenkins PhD, Michael M. Gottesman MD, Matthew D. Hall PhD   +3 more
doaj   +1 more source

Isolation of Taxol and Flavin-like fluorochrome from Endophytic Fungi of Mangifera indica

Journal of Pure and Applied Microbiology, 2021
Scouting for novel and plant-derived biomolecules from endophytic microbial sources draws greater focus on the discovery of novel bioactive metabolites.
Enthai Ganeshan Jagan, Parth Sharma, Senthuran Sureshkumar, Mohan Pandi   +3 more
doaj   +1 more source

Influence of Bioluminescence Imaging Dynamics by D-Luciferin Uptake and Efflux Mechanisms

Molecular Imaging, 2012
Bioluminescence imaging (BLI) detects light generated by luciferase-mediated oxidation of substrate and is used widely for evaluating transgene expression in cell-based assays and in vivo in relevant preclinical models.
Yimao Zhang, Mrudula Pullambhatla, John Laterra, Martin G. Pomper   +3 more
doaj   +1 more source

First Record of Bioluminescence in a Sipunculan Worm

Frontiers in Marine Science, 2021
During a search for bioluminescent marine annelids around the island of Carrie Bow Cay, Belize, we discovered bioluminescence in the sipunculan worm Nephasoma pellucidum. The identification of N. pellucidum was verified by DNA barcoding of ∼650 bp of the
Anderson G. Oliveira, Danilo T. Amaral, Mary Colleen Hannon, Anja Schulze   +3 more
doaj   +1 more source

Genomic and experimental data provide new insights into luciferin biosynthesis and bioluminescence evolution in fireflies

Scientific Reports, 2020
Fireflies are among the most charismatic insects for their spectacular bioluminescence, but the origin and evolution of bioluminescence remain elusive.
Ru Zhang, Jinwu He, Zhiwei Dong, Guichun Liu, Yuan Yin, Xinying Zhang, Qi Li, Yandong Ren, Yongzhi Yang, Wei Liu, Xianqing Chen, Wenhao Xia, Kang Duan, Fei Hao, Zeshan Lin, Jie Yang, Zhou Chang, Ruoping Zhao, Wenting Wan, Sihan Lu, Yanqiong Peng, Siqin Ge, Wen Wang, Xueyan Li   +23 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Successful delivery of viviparous lantern shark from an artificial uterus and the self-production of lantern shark luciferin.

PLoS ONE, 2023
Our recent success in the long-term maintenance of lantern shark embryos in artificial uterine systems has provided a novel option for the medical treatment of premature embryos for captive viviparous elasmobranchs.
Taketeru Tomita, Minoru Toda, Atsushi Kaneko, Kiyomi Murakumo, Kei Miyamoto, Keiichi Sato   +5 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Optogenetic inhibition of neurons by internal light production

Frontiers in Behavioral Neuroscience, 2014
Optogenetics is an extremely powerful tool for selective neuronal activation/inhibition and dissection of neural circuits. However, a limitation of in vivo optogenetics is that an animal must be tethered to an optical fiber for delivery of light.
Benjamin eLand, Catherine eBrayton, Kara eFurman, Zoe eLaPalombara, Ralph eDiLeone   +4 more
doaj   +1 more source