Lycorine Inhibits Hypertrophic Scar Formation by Inducing ROS-Mediated Apoptosis
Frontiers in Bioengineering and Biotechnology, 2022 Background: Hypertrophic scar (HS) is a fibrotic cutaneous disease with few effective therapies. Lycorine is a drug with pro-apoptotic ability and anti-fibrosis potential.
Yunxian Dong +5 more
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In Vitro Inhibition of Alphaviruses by Lycorine [PDF]
Virologica Sinica, 2021 Chikungunya virus (CHIKV) is a mosquito-borne alphavirus. As an emerging virus, CHIKV imposes a threat to public health. Currently, there are no vaccines or antivirals available for the prevention of CHIKV infection. Lycorine, an alkaloid from Amaryllidaceae plants, has antiviral activity against a number of viruses such as coronavirus, flavivirus and ...
Na Li +8 more
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Exploring Therapeutic Targets for Preventing Cardiac Arrest by Modulating Dyslipidemia and 25-Hydroxyvitamin D Metabolism: A Mendelian Randomization Study. [PDF]
Hum MutatCardiac arrest (CA) prevention continues to be a substantial hurdle for global public health. Although dyslipidemia and 25‐hydroxyvitamin D (25(OH)D) insufficiency are recognized contributing factors for cardiovascular disease (CVD), their causal relationship with CA risk is still uncertain.
Jia X +8 more
europepmc +2 more sources
Poultry Science, 2021 : Duck tembusu virus (DTMUV) was firstly identified in 2010 in China; since then, it has caused enormous economic loss to breeding industry. Great efforts have been made to develop drugs and vaccines against DTMUV.
Xuan Lv +11 more
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Pharmacological Research, 2023 Lycorine, an isoquinoline alkaloid can exhibit significant anti-cancer effects. The present study was conducted to illustrate the underlying mechanisms of action of lycorine on breast carcinoma under in vitro and in vivo settings Tandem Mass Tag assay ...
Yanfang Sun +7 more
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Lycorine Derivatives Against Trichomonas vaginalis [PDF]
Chemical Biology & Drug Design, 2012 Six lycorine derivatives were prepared, characterized, and evaluated for their in vitro anti‐Trichomonas vaginalis activity. Compounds bearing an acetyl (2), lauroyl (3), benzoyl (4 and 5), and p‐nitrobenzoyl (6 and 7) groups were synthesized. The best activity was achieved with lycorine esterified at C‐2 position with lauroyl group.
Raquel B, Giordani +6 more
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<i>Lycorine hydrochloride</i> Suppresses the Proliferation and Invasion of Esophageal Cancer by Targeting TRIM22 and Inhibiting the JAK2/STAT3 and Erk Pathways. [PDF]
Cancers (Basel)Liu J, Qiu L, Chen J, Zeng T.
europepmc +2 more sources
Tandem mass tag-based quantitative proteomic analysis of lycorine treatment in highly pathogenic avian influenza H5N1 virus infection [PDF]
PeerJ, 2019 Highly pathogenic H5N1 influenza viruses (HPAIV) cause rapid systemic illness and death in susceptible animals, leading to a disease with high morbidity and mortality rates. Although vaccines and drugs are the best solution to prevent this threat, a more
Li Yang +8 more
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Lycorine Displays Potent Antitumor Efficacy in Colon Carcinoma by Targeting STAT3
Frontiers in Pharmacology, 2018 Signal transducer and activator of transcription 3 (STAT3) is an attractive therapeutic target for cancer treatment. In this study, we identify lycorine is an effective inhibitor of STAT3, leading to repression of multiple oncogenic processes in colon ...
Song Wu +14 more
doaj +1 more source
Relevant and selective activity of Pancratium illyricum L. against Candida albicans clinical isolates: a combined effect on yeast growth and virulence [PDF]
, 2014 BACKGROUND: Alkaloids present in plants of the Amaryllidaceae family are secondary metabolites of high biological interest, possessing a wide range of pharmacological activities. In the search for new plant-derived compounds with antimicrobial activities,
Antognoni, F +5 more
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