Results 51 to 60 of about 3,794 (236)

Cytotoxicity and Antioxidant Activity of Zingiber Officinale and 6-Gingerol on HepG2 Cells [PDF]

, 2008
The present study was designed to compare the effects of ethanolic extract of ginger (Zingiber officinale) and its phenolic component [6]-Gingerol on viability, antiproliferation and apoptotic levels of human hepatoma cell lines (HepG2) and its ...
Hanif, H. (Harliansyah), Murad, N. A. (Noor), Wan Ngah, Wan Zurinah, Yusof, Y. A. (Yasmin)   +3 more
core   +2 more sources

Lycorine Alkaloid and Crinum americanum L. (Amaryllidaceae) Extracts Display Antifungal Activity on Clinically Relevant Candida Species

Molecules, 2022
Candida species are the main fungal agents causing infectious conditions in hospital patients. The development of new drugs with antifungal potential, increased efficacy, and reduced toxicity is essential to face the challenge of fungal resistance to ...
Lorene Coelho Silva, Amabel Fernandes Correia, João Victor Dutra Gomes, Wanderson Romão, Larissa Campos Motta, Christopher William Fagg, Pérola Oliveira Magalhães, Dâmaris Silveira, Yris Maria Fonseca-Bazzo   +8 more
doaj   +1 more source

Discovery of anthelmintic drug targets and drugs using chokepoints in nematode metabolic pathways [PDF]

, 2013
Parasitic roundworm infections plague more than 2 billion people (1/3 of humanity) and cause drastic losses in crops and livestock. New anthelmintic drugs are urgently needed as new drug resistance and environmental concerns arise. A "chokepoint reaction"
Abubucker, Sahar, Huang, Stanley Ching-Cheng, Mitreva, Makedonka, Pearce, Edward J, Powell, Kerrie, Rosa, Bruce A, Schedl, Tim, Taylor, Christina M, Wang, Qi   +8 more
core   +4 more sources

Anti-SARS-CoV-2 Activity and Cytotoxicity of Amaryllidaceae Alkaloids from Hymenocallis littoralis

Molecules, 2023
The Amaryllidaceae species are well-known as a rich source of bioactive compounds in nature. Although Hymenocallis littoralis has been studied for decades, its polar components were rarely explored.
Ngoc-Thao-Hien Le, Steven De Jonghe, Kristien Erven, Tom Vermeyen, Aliou M. Baldé, Wouter A. Herrebout, Johan Neyts, Christophe Pannecouque, Luc Pieters, Emmy Tuenter   +9 more
doaj   +1 more source

Synthesis and biological evaluation of lycorine derivatives as dual inhibitors of human acetylcholinesterase and butyrylcholinesterase

Chemistry Central Journal, 2012
Background Alzheimer’s disease (AD) is a neurologically degenerative disorder that affects more than 20 million people worldwide. The selective butyrylcholinesterase (BChE) inhibitors and bivalent cholinesterase (ChE) inhibitors represent new treatments ...
Wang Yue-Hu, Wan Qin-Li, Gu Cheng-Ding, Luo Huai-Rong, Long Chun-Lin   +4 more
doaj   +1 more source

Study of Molecular Docking of Alkaloid Derivative Compounds from Stem Karamunting (Rhodomyrtus tomentosa) Against α-glucosidase Enzymes [PDF]

, 2021
Karamunting plant (Rhodomyrtus tomentosa) is a traditional medicinal plant. The leaves, roots, stems, and fruits of Karamunting have been identified, and their biological activities are antioxidants, antibacterial, antidiabetic, anti-inflammatory, and ...
mulyati, Budi, Seulina Panjaitan, Riong
core   +2 more sources

Thiophenderivate als vielseitige Vorstufen für die Synthese von (Hetero)aromaten und Naturstoffen

Angewandte Chemie, Volume 138, Issue 5, 28 January 2026.
Verborgen, aber leistungsstark: Thiophene und ihre gesättigten Analoga haben sich als vielseitige C4‐Bausteine erwiesen, die sich effektiv in der Naturstoffsynthese sowie beim Aufbau funktionalisierter (Hetero)aromaten einsetzen lassen. Dieser Minireview soll einen Überblick über Strategien zur Anwendung dieser schwefelhaltigen heterozyklischen ...
Anna Keimer, Franz‐Lucas Haut
wiley   +1 more source

Anti-nausea effects and pharmacokinetics of ondansetron, maropitant and metoclopramide in a low-dose cisplatin model of nausea and vomiting in the dog: a blinded crossover study [PDF]

, 2017
Nausea is a subjective sensation which is difficult to measure in non-verbal species. The aims of this study were to determine the efficacy of three classes of antiemetic drugs in a novel low dose cisplatin model of nausea and vomiting and measure change
A Freeman, A Tidholm, AM Holmes, B Otto, C Pirri, C Rojas, CC Horn, CC Horn, CJ Henry, DB Smith, DB Zamble, DG Warr, F Roila, F Roila, FD Tattersall, GJ Sanger, GJ Sanger, GR Morrow, H Fukui, H Fukui, H Kenward, H Kenward, Hannah Kenward, JA Gylys, JA Rudd, Jonathan Elliott, K Olsson, Ludovic Pelligand, LX Cubeddu, M Marty, M Mutoh, N Percie du Sert, N Percie du Sert, PH Mulder De, PJ Hesketh, PJ Hesketh, PL Andrews, RJ Gralla, RM Stern, RM Stern, S Kretzing, S Poli-Bigelli, SG Allan, SP Chawla, Terry Lee, TM Hyde, V Napadow, VA Puente-Redondo de la   +47 more
core   +1 more source

Thiophene Derivatives as Versatile Precursors for (Hetero)Arene and Natural Product Synthesis

Angewandte Chemie International Edition, Volume 65, Issue 5, 28 January 2026.
Hidden but Powerful: Thiophenes and their saturated analogues have been demonstrated to be versatile C4‐building blocks that can be rapidly applied to natural product synthesis and the construction of functionalized (hetero)arenes. This minireview aims to provide a concise overview of the strategies and implementations of these sulfur‐containing ...
Anna Keimer, Franz‐Lucas Haut
wiley   +1 more source

Galantamine Quantity and Alkaloid Profile in the Bulbs of Narcissus tazetta and daffodil cultivars (Amaryllidaceae) Grown in Israel

Metabolites, 2021
Alkaloids produced by the bulbs of the Amaryllidaceae are a source of pharmaceutical compounds. The main alkaloid, galantamine, is a reversible acetylcholinesterase inhibitor and allosteric nicotinic receptor modulator, which slows cognitive and ...
Dana Atrahimovich, Raviv Harris, Ron Eitan, Menashe Cohen, Soliman Khatib   +4 more
doaj   +1 more source