Results 81 to 90 of about 34,914 (256)

Squamous Cell Carcinoma of the Lung With Microsatellite Instability in a Patient With Lynch Syndrome: A Case Report

JTO Clinical and Research Reports
Lynch syndrome is the most common autosomal dominant inherited cancer predisposing syndrome, due to mutations in DNA mismatch repair genes. The key feature of cancers in Lynch syndrome is microsatellite instability and a high risk of developing mainly ...
Emna Haddad, MD, Benjamin Bottet, MD, Pierre-Alain Thiebaut, MD, PhD, Samira Morin, MD, Hélène Dreyfus, MD, Élise Vannier, MD, Colette Vincent, MD, Florent Marguet, MD, PhD, Aude Lamy, PhD, Hagay Sobol, MD, PhD, Jean-Marc Baste, MD, PhD, Florian Guisier, MD, PhD, Jean-Christophe Sabourin, MD, PhD, Nicolas Piton, MD, PhD   +13 more
doaj   +1 more source

Diagnosis and clinical behavior in patients with Lynch-like syndrome

Revista de Gastroenterología de México (English Edition), 2018
Introduction and aims: Lynch-like syndrome is diagnosed when there is an expression deficit in DNA mismatch repair proteins but a normal genetic study. The behavior and management of that pathology are currently a subject of debate. We present herein the
L. Adán-Merino, M. Aldeguer-Martínez, E. Alonso-Gamarra, F. Valentín-Gómez, C. Zaera-De la Fuente, S. Martín-Chávarri   +5 more
doaj   +1 more source

Insertion of an SVA element in MSH2 as a novel cause of Lynch syndrome [PDF]

, 2021
Ciyu Yang, Yirong Li, Magan Trottier, Michael Farrell, Vikas Rai, Erin Salo‐Mullen, David Gallagher, Zsofia K. Stadler, Heleen M. van der Klift, Liying Zhang   +9 more
openalex   +1 more source

Human papilloma virus infection and mismatch repair protein expression in sebaceous neoplasms of the genital area

Histopathology, EarlyView.
This study establishes the role of high‐risk HPV infection in cutaneous sebaceous carcinoma of the genital area. An intraepithelial component in a subset of cases poses a challenge to distinguish the entity from squamous cell carcinoma in situ. Rarely, sebaceous neoplasia of the genital area is associated with Muir–Torre syndrome. Aims This study aimed
Katharina Wiedemeyer, Zainab Al‐Shamma, Martin Köbel, Ingrid Ferreira, Paul W. Harms, Thomas Brenn   +5 more
wiley   +1 more source

Systematic Review: An Update on the Spectrum of Urological Malignancies in Lynch Syndrome

Bladder Cancer, 2018
Background: Lynch syndrome is an autosomal dominant disorder that predisposes individuals affected to certain malignancies. Colon and endometrial cancers are the malignancies most highly associated with Lynch syndrome.
Dora Huang, Surena F. Matin, Nathan Lawrentschuk, Morgan Roupret   +3 more
doaj   +1 more source

Lynch syndrome-associated endometrial carcinoma with MLH1 germline mutation and MLH1 promoter hypermethylation: a case report and literature review

BMC Cancer, 2018
Background Lynch syndrome is an autosomal dominant inherited disease caused by germline mutations in mismatch repair genes. Analysis for microsatellite instability (MSI) and immunohistochemistry (IHC) of protein expressions of disease-associated genes is
Takanori Yokoyama, Kazuhiro Takehara, Nao Sugimoto, Keika Kaneko, Etsuko Fujimoto, Mika Okazawa-Sakai, Shinichi Okame, Yuko Shiroyama, Takashi Yokoyama, Norihiro Teramoto, Shozo Ohsumi, Shinya Saito, Kazuho Imai, Kokichi Sugano   +13 more
doaj   +1 more source

Cost-Effectiveness Analysis of Molecular Screening to Identify Lynch Syndrome in the Patients with Colorectal Cancer [PDF]

, 2021
Hananeh Azardoost, Farimah Rahimi, Mehrdad Zeinalian, Reza Rezayatmand   +3 more
openalex   +1 more source

Activation of the Lectin Pathway Drives Persistent Complement Dysregulation in Long COVID

Immunology, EarlyView.
The complement cascade, a series of blood proteins that assists in the recognition and neutralisation of pathogens, either independently or in conjunction with antibodies, is persistently activated in patients with long COVID. We found that blood plasma samples from patients with long COVID contained elevated concentrations of the mannan‐binding lectin‐
Samuel B. K. Keat, Priyanka Khatri, Youssif M. Ali, Chanuka H. Arachchilage, Gregory Demopulos, Kirsten Baillie, Kelly L. Miners, Kristin Ladell, Samantha A. Jones, Helen E. Davies, David A. Price, Wioleta M. Zelek, B. Paul Morgan, Wilhelm J. Schwaeble, Nicholas J. Lynch   +14 more
wiley   +1 more source

An Unusual Presentation of Synchronous Breast Cancer and Skin Malignancy in a Patient with Lynch Syndrome: A Case Report and Review of the Literature

Biomedicines
Background: Lynch syndrome is an autosomal dominant condition that leads to an increased risk of many neoplasms. In the United Kingdom, NICE recommends that patients with colorectal and endometrial cancer should be tested for Lynch syndrome.
Maiar Elghobashy, Michael Siafakas, Mona Elshafie, Rahul Hejmadi, Naren N. Basu, Abeer M. Shaaban   +5 more
doaj   +1 more source

Mind the gap: challenges in the clinical management of Lynch syndrome families [PDF]

, 2011
Carin R. Huizenga, Arelis Martir-Negron, Kathleen R. Blazer, Julie O. Culver, Deborah J. MacDonald, Jeffrey N. Weitzel   +5 more
openalex   +1 more source