Results 61 to 70 of about 1,085 (178)

Stabilized Extracellular Vesicle Formulations for Inhalable Dry Powder Development

Small, Volume 22, Issue 16, 17 March 2026.
Extracellular vesicles (EVs) hold promise for chronic obstructive pulmonary disease (COPD) treatment but face challenges with storage and delivery. This study demonstrates the stabilization of lung fibroblast‐derived EVs using inulin, enabling freeze‐drying and spray‐drying.
Eva M. Jansen, Luke van der Koog, Robin A.B. Elferink, Karim Rafie, Anika Nagelkerke, Reinoud Gosens, Henderik W. Frijlink, Wouter L.J. Hinrichs   +7 more
wiley   +1 more source

Preliminary Research on Freeze-drying Preservation of Human Hepatoma Hep-G2 Cells

Zhileng xuebao, 2017
Freeze-drying is a long-term and effective method for cell preservation. The lyoprotectant can have a significant effect on cell freeze-drying. In this study, different volume concentrations of Me2SO, glycerol, and different mass concentrations ...
Song Ping, Li Weijie, Zhou Xinli, Liu Baolin   +3 more
doaj  

Excipients for the lyoprotection of MAPKAP kinase 2 inhibitory peptide nano-polyplexes

Journal of Controlled Release, 2018
Herein, excipients are investigated to ameliorate the deleterious effects of lyophilization on peptide-polymer nano-polyplex (NP) morphology, cellular uptake, and bioactivity. The NPs are a previously-described platform technology for intracellular peptide delivery and are formulated from a cationic therapeutic peptide and the anionic, pH-responsive ...
Alvin J, Mukalel, Brian C, Evans, Kameron V, Kilchrist, Eric A, Dailing, Benjamin, Burdette, Joyce, Cheung-Flynn, Colleen M, Brophy, Craig L, Duvall   +7 more
openaire   +3 more sources

Trehalose Crystallization During Freeze-Drying: Implications On Lyoprotection

, 2015
Lyoprotectants are stabilizers used to prevent denaturation of proteins during freeze-drying and subsequent storage. In order to be effective, lyoprotectants must be retained amorphous.
Raj Suryanarayanan (1246851), Prakash Sundaramurthi (1268358)   +1 more
core   +1 more source

Drug Product Development of Lipid Nanoparticle‐Based mRNA Therapeutics and Vaccines

WIREs Nanomedicine and Nanobiotechnology, Volume 18, Issue 2, March/April 2026.
Overview of the development path from an mRNA–lipid nanoparticle (LNP) concept to a licensed drug product, covering LNP design, manufacturing process development, formulation, and analytical characterization. ABSTRACT Lipid nanoparticles (LNP) are currently the most relevant non‐viral delivery systems for mRNA and occasionally for smaller nucleic acids
Gideon Kersten, Eleonora Cerasoli, Bruce Kerwin, Olivia M. Merkel, Andrea Hawe   +4 more
wiley   +1 more source

Lyoprotection and stabilization of laccase extract from Coriolus hirsutus, using selected additives [PDF]

AMB Express, 2018
The development of stable lyophilized laccase, obtained from Coriolus hirsutus, using a wide range of temperature treatments and storage conditions, was investigated. Using selected lyoprotectants, including, dextran 6 kDa, sucrose and a mixture of sodium benzoate, potassium sorbate and sorbitol (BKSS) (1.5:1.0:98.5; w/w/w) resulted by 2.4, 1.4 and 1.8-
Christelle Bou-Mitri, Selim Kermasha
openaire   +3 more sources

Nanomedicine Strategies Against Biofilm‐Associated Infections: Advances, Challenges, and Translational Barriers

MicrobiologyOpen, Volume 15, Issue 1, February 2026.
Explore the key challenges and limitations in nanomedicine for biofilm treatment, from drug loading efficiency to antimicrobial resistance. ABSTRACT Antimicrobial resistance continues to rise globally, with biofilm‐associated infections intensifying the clinical burden through persistent tolerance to antibiotics and evasion of immune responses ...
Husni Farah, Munthar Kadhim‐Abosaoda, Hayjaa Mohaisen‐Mousa, S. Renuka Jyothi, Priya Priyadarshini‐Nayak, J. Bethanney Janney, Gurjant Singh, Ashish Singh‐Chauhan, Manoj Kumar‐Mishra   +8 more
wiley   +1 more source

Freezing the Moment: Monitoring Freezing Processes Under MAS Conditions

Magnetic Resonance in Chemistry, Volume 64, Issue 2, Page 193-206, February 2026.
NMR spectroscopy under magic angle spinning conditions allows studying the freezing of aqueous solutions and gel‐like systems down to subfreezing temperatures. We thoroughly monitored the freezing process of various aqueous systems containing multiple NMR‐active nuclei (1H, 11B, 13C, 23Na, and 79Br). We focus on prerequisites, problems, and limitations
Sebastian Scheidel, Elena Behr, Ann‐Christin Pöppler   +2 more
wiley   +1 more source

Injectable Chitosan‐Platelet‐Rich Plasma Hybrid Biomaterial Improves Skin Wound Healing in Diabetic Rats

Advanced Therapeutics, Volume 9, Issue 1, January 2026.
A biomaterial combining fresh platelet‐rich plasma with freeze‐dried chitosan (CS‐PRP) enhances diabetic skin wound healing in rats. CS‐PRP accelerates closure over the course of a month, improves healing tissue architecture and collagen remodeling, and sustains vascularization.
Laura Ahunon, Anik Chevrier, Léo‐Paul Tricou, Aurélie Huppé, Julie Fradette, Marc Lavertu   +5 more
wiley   +1 more source

Characteristics, Release, and Stability (Kinetics and Shelf-life) of Ciprofloxacin HCl-Alginate-Carrageenan Microspheres: Effects of Drug Concentration and Type of Lyoprotectant

Science and Technology Indonesia
Tuberculosis, an infectious disease caused by the Mycobacterium tuberculosis bacteria, is one of the main causes of death worldwide. Alternative treatments are necessary due to the rising prevalence of medication resistance in Mycobacterium tuberculosis.
Amiruddin, Mahardian Rahmadi, Dewi Melani Hariyadi   +2 more
doaj   +1 more source