Improving Ergometrine Production by easO and easP Knockout in Claviceps paspali
Ergometrine is widely used for the treatment of excessive postpartum uterine bleeding. Claviceps paspali is a common species for industrial production of ergometrine, which is often accompanied by lysergic acid α-hydroxyethylamide (LAH) and lysergic acid
Yun-Ming Qiao+6 more
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Drugs in therapy. LSD, MDMA, marijuana, psilocybin, designer drugs and its potential in modern medicine. [PDF]
Research on using drugs in medicine was almost completely stopped and delegalized in 1971, by Convention on Psychotropic Substances. Most of studies carried out before 1971 were methodologically inappropriate according to current research methodologies ...
Agata Tadeja
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Introduction Zebrafish (Danio rerio) has evolved over the years as a preferred organism due to its vast repertoire in research fields that mimic a targeted phenotype, particularly behavioral typologies and specific attributes comparable to murine models
I. B. Nita+5 more
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Return of the lysergamides. Part II: Analytical and behavioural characterization of N6‐allyl‐6‐norlysergic acid diethylamide (AL‐LAD) and (2’S,4’S)‐lysergic acid 2,4‐dimethylazetidide (LSZ) [PDF]
Lysergic acid N,N-diethylamide (LSD) is perhaps one of the most intriguing psychoactive substances known and numerous analogs have been explored to varying extents in previous decades.
Simon D. Brandt+10 more
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After more than sixty years we are still unclear whether LSD has a place in clinical psychiatry
Dear Editor, The use of the psychedelic Lysergic Acid Diethylamide (LSD) has again provoked scientific debate over its efficacy and safety. In the 1950s-1960s LSD was used in psychotherapy for treating depression, anxiety related to terminal cancer ...
arthur saniotis
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Suicidal cut‐throat wound during LSD intoxication
Lysergic acid diethylamide (LSD) is a potent hallucinogenic drug affecting the mood and perception of an individual. Although LSD‐induced self‐inflicted cut‐throat wounds and self‐harm injuries are extremely rarely reported behaviors, some reports are ...
Palash Kumar Bose+3 more
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Healthcare providers face the challenging task of managing patients who suffer from chronic nociplastic pain conditions. Pain is a multidimensional experience, and the current approach to managing people in chronic pain often fails to meet the needs
J Van Der Walt, R Parker
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Pharmacokinetics and Pharmacodynamics of Lysergic Acid Diethylamide in Healthy Subjects [PDF]
Background and ObjectiveLysergic acid diethylamide (LSD) is used recreationally and in clinical research. The aim of the present study was to characterize the pharmacokinetics and exposure–response relationship of oral LSD.MethodsWe analyzed ...
Patrick C. Dolder+6 more
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BMC Microbiology / Rhodococcus erythropolis MTHt3 biotransforms ergopeptines to lysergic acid [PDF]
Background: Ergopeptines are a predominant class of ergot alkaloids produced by tall fescue grass endophyte Neotyphodium coenophialum or cereal pathogen Claviceps purpurea.
Apfelthaler, Elisabeth+7 more
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Self unbound: ego dissolution in psychedelic experience [PDF]
Users of psychedelic drugs often report that their sense of being a self or ‘I’ distinct from the rest of the world has diminished or altogether dissolved.
Gerrans, Philip, Letheby, Chris
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