Results 1 to 10 of about 2,537 (120)

Lysine lactylation in diseases: beyond histone lactylation [PDF]

Cell Death and Disease
Lactylation, a recently identified post-translational modification, was initially characterized as lysine residue modification in histone subunits that regulates gene transcription via epigenetic mechanisms.
Yiming Liu, Xuan Guo, Xinyang Hu, Sining Zhou, Qi Yang, Pingping Feng, Linghui Zeng   +6 more
doaj   +3 more sources

Recent advances of lysine lactylation in prokaryotes and eukaryotes [PDF]

Frontiers in Molecular Biosciences
Lysine lactylation is a newly discovered protein post-translational modification that plays regulatory roles in cell metabolism, growth, reprogramming, and tumor progression.
Wenjuan Zhao, Wenjuan Zhao, Jiayi Xin, Jiayi Xin, Xin Yu, Zhifang Li, Nan Li   +6 more
doaj   +3 more sources

Lactate and lysine lactylation of histone regulate transcription in cancer [PDF]

Heliyon
Histone lysine modifications were well-established epigenetic markers, with many types identified and extensively studied. The discovery of histone lysine lactylation had revealed a new form of epigenetic modification.
Yunhao Yang, Nanzhi Luo, Zhipeng Gong, Wenjing Zhou, Yin Ku, Yaohui Chen   +5 more
doaj   +4 more sources

Deciphering novel enzymatic and non-enzymatic lysine lactylation in Salmonella [PDF]

Emerging Microbes and Infections
Lysine lactylation, a novel post-translational modification, is involved in multiple cellular processes. The role of lactylation remains largely unknown, especially in bacteria.
Chuanzhen Zhang, Tao Zhou, Chengxi Li, Danni Wang, Jing Tao, Xiaocen Zhu, Jie Lu, Jinjing Ni, Yu-Feng Yao   +8 more
doaj   +4 more sources

Comprehensive analysis of lysine lactylation in Frankliniella occidentalis. [PDF]

Front Genet, 2022
Western flower thrips (Frankliniella occidentalis) are among the most important pests globally that transmit destructive plant viruses and infest multiple commercial crops. Lysine lactylation (Klac) is a recently discovered novel post-translational modification (PTM).
An D, Song L, Li Y, Shen L, Miao P, Wang Y, Liu D, Jiang L, Wang F, Yang J.   +9 more
europepmc   +4 more sources

Class I histone deacetylases catalyze lysine lactylation. [PDF]

J Biol Chem
AbstractMetabolism and post-translational modifications (PTMs) are intrinsically linked and the number of identified metabolites that can covalently modify proteins continues to increase. This metabolism/PTM crosstalk is especially true for lactate, the product of anaerobic metabolism following glycolysis.
Gonzatti MB, Hintzen JCJ, Sharma I, Najar MA, Tsusaka T, Marcinkiewicz MM, Da Silva Crispim CV, Snyder NW, Burslem GM, Goldberg EL.   +9 more
europepmc   +4 more sources

YiaC and CobB regulate lysine lactylation in Escherichia coli. [PDF]

Nat Commun, 2022
AbstractLysine lactylation (Kla) has recently been reported to participate in regulating transcription in human cells. However, the characterization, regulatory mechanism and functional consequence of Kla in prokaryotes remain unclear. Here, we report that YiaC functions as a lysine lactylase and that CobB serves as a lysine delactylase in the ...
Dong H, Zhang J, Zhang H, Han Y, Lu C, Chen C, Tan X, Wang S, Bai X, Zhai G, Tian S, Zhang T, Cheng Z, Li E, Xu L, Zhang K.   +15 more
europepmc   +4 more sources

Lysine lactylation regulates ATF4-mediated stress responses under glucose starvation in canine hemangiosarcoma [PDF]

Frontiers in Veterinary Science
Excess lactate is produced in tumor cells by aerobic glycolysis and regulates gene expressions by histone lactylation. However, how histone lactylation functions under glucose-limited conditions remains unknown.
Tamami Suzuki, Kazuki Heishima, Kazuki Heishima, Kazuki Heishima, Jumpei Yamazaki, Jumpei Yamazaki, Masaya Yamazaki, Ryohei Kinoshita, Ryohei Kinoshita, Sangho Kim, Sangho Kim, Sangho Kim, Kenji Hosoya, Kenji Hosoya, Kenji Hosoya, Yuko Okamatsu-Ogura, Michihito Sasaki, Peng Xu, Qin Yan, Takashi Kimura, Keisuke Aoshima, Keisuke Aoshima   +21 more
doaj   +2 more sources

Global Analysis of Lysine Lactylation of Germinated Seeds in Wheat. [PDF]

Int J Mol Sci, 2023
Protein lactylation is a newly discovered posttranslational modification (PTM) and is involved in multiple biological processes, both in mammalian cells and rice grains. However, the function of lysine lactylation remains unexplored in wheat. In this study, we performed the first comparative proteomes and lysine lactylomes during seed germination of ...
Zhu J, Guo W, Lan Y.
europepmc   +3 more sources

Infection-induced lysine lactylation enables herpesvirus immune evasion. [PDF]

Sci Adv
Aerobic glycolysis is a hallmark of many viral infections, leading to substantial accumulation of lactate. However, the regulatory roles of lactate during viral infections remain poorly understood. Here, we report that human cytomegalovirus (HCMV) infection leverages lactate to induce widespread protein lactylation and promote viral spread.
Tyl MD, Merengwa VU, Cristea IM.
europepmc   +3 more sources