Results 101 to 110 of about 2,589 (171)

Histone Lactylation as an Epigenetic Regulator in Alzheimer’s Disease Pathophysiology: A Narrative Review

Journal of Inflammation Research
Jingkai Tang,1,* Yiwei Zhang,1,* Yibing Wang,1,* Yanxin Fu,1 Jingman Qi,1 Aomeng Xiang,1 Ruoxuan Zhao,1 Ge Tan,1 Huili Deng,2 Xuchang Zhou,2 Liang Wu3 1Department of Sport Rehabilitation, Tianjin University of Sport, Tianjin ...
Tang J, Zhang Y, Wang Y, Fu Y, Qi J, Xiang A, Zhao R, Tan G, Deng H, Zhou X, Wu L   +10 more
doaj  

Lactate-driven lactylation of HNRNPA1 orchestrates PKM2 splicing and glycolytic reprogramming in bladder cancer

Journal of Experimental & Clinical Cancer Research
Background Lactylation, a recently identified post-translational modification derived from lactate, has emerged as a regulator of tumor metabolism. However, its functional relevance and molecular targets in bladder cancer (BLCA) remain unclear.
Tianqi Wang, Xiaohong Ma, Yini Wang, Hongquan Liu, Guixin Ding, Yanfei Li, Hejia Yuan, Jie Gao, Fengze Sun, Yicheng Guo, Jian Ma, Jitao Wu   +11 more
doaj   +1 more source

The lactylation-macrophage interplay: implications for gastrointestinal disease therapeutics

Frontiers in Immunology
Lactate, a key metabolic byproduct of the Warburg effect, has lately been recognized as a regulator of histone lysine lactylation, a unique post-translational modification that plays a crucial role in essential biological processes, including the ...
Xinzhen Che, Yixin Zhang, Xiqi Chen, Guangdong Xie, Jinling Li, Chengchao Xu, Chunhua Zhang, Yong Zhu, Xinyu Yang   +8 more
doaj   +1 more source

APP lysine 612 lactylation ameliorates amyloid pathology and memory decline in Alzheimer’s disease

Journal of Clinical Investigation
Posttranslational modification (PTM) of the amyloid precursor protein (APP) plays a critical role in Alzheimer's disease (AD). Recent evidence reveals that lactylation modification, as a novel PTM, is implicated in the occurrence and development of AD. However, whether and how APP lactylation contributes to both the pathogenesis and cognitive function ...
Qiuyun Tian, Junjie Li, Bin Wu, Yayan Pang, Wenting He, Qian Xiao, Jiaojiao Wang, Lilin Yi, Na Tian, Xiuyu Shi, Lei Xia, Xin Tian, Mulan Chen, Yepeng Fan, Boqing Xu, Yuhan Tao, Weihong Song, Yehong Du, Zhifang Dong   +18 more
openaire   +2 more sources

Integrated analysis of histone lysine lactylation (Kla)-specific genes suggests that NR6A1, OSBP2 and UNC119B are novel therapeutic targets for hepatocellular carcinoma. [PDF]

Sci Rep, 2023
Wu Q, Li X, Long M, Xie X, Liu Q.
europepmc   +1 more source

DeepKla: An attention mechanism-based deep neural network for protein lysine lactylation site prediction. [PDF]

Imeta, 2022
Lv H, Dao FY, Lin H.
europepmc   +1 more source

Post-translational changes in <i>Phialophora verrucosa via</i> lysine lactylation during prolonged presence in a patient with a <i>CARD9</i>-related immune disorder. [PDF]

Front Immunol, 2022
Song Y, Liu X, Stielow JB, de Hoog S, Li R.   +4 more
europepmc   +1 more source

<i>Porphyromonas gingivalis</i> infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells. [PDF]

Front Cell Infect Microbiol
Wu Q, Li Z, Gong T, Zheng X, Zhou X, Peng X.   +5 more
europepmc   +1 more source

Glutamine relieves feed restriction-induced ruminal epithelial function damage through histone lysine lactylation in yaks. [PDF]

J Anim Sci Biotechnol
Yue Z, Shi L, Wang Z, Hu R, Peng Q, Zou H, Xiao J, Jiang Y, Wu F, Tang Y.   +9 more
europepmc   +1 more source

HDAC2 as a therapeutic target in bladder cancer: insights into the altered epigenetic regulation and lysine lactylation. [PDF]

J Exp Clin Cancer Res
Xu G, Liang S, Hu G, Zhao W, Li Y, Zheng M, Wu Z, Xie T, Fang S, Peng S, Deng Y, Zhou Y, Guo H, Zhuang J, Diao W.   +14 more
europepmc   +1 more source