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Global Profiling of Lysine Acetylation and Lactylation in Kupffer Cells
Journal of Proteome Research, 2023Among the various cell types that constitute the liver, Kupffer cells (KCs) are responsible for the elimination of gut-derived foreign products. Protein lysine acetylation (Kac) and lactylation (Kla) are dynamic and reversible post-translational modifications, and various global acylome studies have been conducted for liver and liver-derived cells ...
Eunji Sung +6 more
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Comprehensive Analysis of Lysine Lactylation in Rice (Oryza sativa) Grains
Journal of Agricultural and Food Chemistry, 2021Protein lysine lactylation is a new post-translational modification (PTM) prevalently found in fungi and mammalian cells that directly stimulates gene transcription and regulates the glycolytic flux. However, lysine lactylation sites and regulations remain largely unexplored, especially in cereal crops.
Xiaoxi Meng +3 more
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Subcellular Proteomic Mapping of Lysine Lactylation
Journal of the American Society for Mass SpectrometryProtein lactylation is a novel post-translational modification (PTM) involved in many important physiological processes such as macrophage polarization, immune regulation, and tumor cell growth. However, traditional methodologies for studying lactylation have predominantly relied on peptide enrichment from whole-cell lysates, which tend to favor the ...
Qiuyu Bao +6 more
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Lysine lactylation regulates metabolic pathways and biofilm formation in Streptococcus mutans
Science Signaling, 2023In eukaryotes, lactate produced during glycolysis is involved in regulating multiple metabolic processes through lysine lactylation (Kla). To explore the potential link between metabolism and Kla in prokaryotes, we investigated the distribution of Kla in the cariogenic bacterium Streptococcus mutans during ...
Zhengyi Li +8 more
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The Oncogenic Regulation of Histone Lysine Lactylation
2021L-lactate is generated during glycolysis, a metabolic pathway that is widely associated with many physiological and disease related processes. We recently reported the discovery of lysine L-lactylation [K(L-la)] as a novel protein posttranslational modification occurring on histone proteins that can contribute to gene transcription.
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Emerging roles of lysine lactyltransferases and lactylation
Nature Cell BiologyGiven its various roles in cellular functions, lactate is no longer considered a waste product of metabolism and lactate sensing is a pivotal step in the transduction of lactate signals. Lysine lactylation is a recently identified post-translational modification that serves as an intracellular mechanism of lactate sensing and transfer.
Zhi Zong +4 more
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Lysine lactylation in the regulation of tumor biology
Trends in Endocrinology & MetabolismLysine lactylation (Kla), a newly discovered post-translational modification (PTM) of lysine residues, is progressively revealing its crucial role in tumor biology. A growing body of evidence supports its capacity of transcriptional regulation through histone modification and modulation of non-histone protein function.
Zijian Yang, Yingqi Zheng, Qiang Gao
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Histone Lysine Lactylation Regulates Gene Expression
Cancer Discovery, 2019Abstract A previously unknown histone modification, lysine lactylation, was found in mouse and human cells.
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Regulation of newly identified lysine lactylation in cancer
Cancer LettersMetabolic reprogramming is a typical hallmark of cancer. Enhanced glycolysis in tumor cells leads to the accumulation of lactate, which is traditionally considered metabolic waste. With the development of high-resolution liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS), the lactate-derived, lysine lactylation(Kla), has been ...
Xin, Gao +5 more
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