Results 141 to 150 of about 2,589 (171)

Current and future perspectives of lysine lactylation in cancer

Trends in Cell Biology
Lactate, a glycolytic intermediate, has a crucial role in cancer metabolism and microenvironment remodeling. Recently, researchers found that lactate mediates lysine lactylation, a novel protein post-translational modification (PTM). Here, we summarize the mechanism and role of lysine lactylation in cancer, and discuss the potential of targeting lysine
Sijia Li, Lixia Dong, Kui Wang
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Lysine lactylation-based insight to understanding the characterization of cervical cancer

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Lysine lactylation (Kla), a recently discovered post-translational modification (PTM), is not only present in histone proteins but also widely distributed among non-histone proteins in tumor cells and immunocytes. However, the precise characterization and functional implications of these non-histone Kla proteins remain to be explored.
Chaoran, He, Jianji, Zhang, Xue, Bai, Congcong, Lu, Kai, Zhang   +4 more
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ACSF2 and lysine lactylation contribute to renal tubule injury in diabetes

Diabetologia
Lactate accumulation is reported to be a biomarker for diabetic nephropathy progression. Lactate drives lysine lactylation, a newly discovered post-translational modification that is involved in the pathogenesis of cancers and metabolic and inflammatory disease.
Jingfang Chen, Qi Feng, Yingjin Qiao, Shaokang Pan, Lulu Liang, Yong Liu, Xiaonan Zhang, Dongwei Liu, Zhihong Liu, Zhangsuo Liu   +9 more
openaire   +2 more sources

Efficient synthesis of lactylated histone peptides enabled by a pre-prepared protected lactylated-lysine

Tetrahedron Letters, 2023
Qingyao Shu, Jian Fan, Bingji Wang, Jing Shi   +3 more
openaire   +1 more source

Comprehensive observation of histone lysine lactylation during gametogenesis of Drosophila melanogaster

Developmental Dynamics
Abstract Background Histone post‐translational modification (PTM) is an important epigenomic regulation content and an essential process regulating gene expression. Histone lysine lactylation is the newly identified histone PTM that utilizes the lactyl moiety for its ...
Yoshiki Hayashi, Ban Sato, Rio Kageyama, Kenji Miyado, Daisuke Saito, Satoru Kobayashi, Natsuko Kawano   +6 more
openaire   +2 more sources

Integrative oncology: Addressing the global challenges of cancer prevention and treatment

Ca-A Cancer Journal for Clinicians, 2022
Jun J Mao,, Msce, Lorenzo Cohen, Karen M Mustian   +2 more
exaly  

Multifaceted Roles of Histone Lysine Lactylation in Meiotic Gene Dynamics and Recombination

AbstractMale germ cells, which are responsible for producing millions of genetically diverse sperm through meiosis in the testis, rely on lactate as their central energy metabolite. Recent study has revealed that lactate induces epigenetic modification in cells through histone lactylation, a post-translational modification involving the addition of ...
Xiaoyu, Zhang, Yan, Liu, Ning, Wang
openaire   +2 more sources

Obesity and adverse breast cancer risk and outcome: Mechanistic insights and strategies for intervention

Ca-A Cancer Journal for Clinicians, 2017
Cynthia Morata-Tarifa, Joyce M Slingerland   +1 more
exaly  

Multidisciplinary standards of care and recent progress in pancreatic ductal adenocarcinoma

Ca-A Cancer Journal for Clinicians, 2020
Aaron J Grossberg, William L Hwang, Anirban Maitra   +2 more
exaly  

Oral complications of cancer and cancer therapy

Ca-A Cancer Journal for Clinicians, 2012
Joel B Epstein, Rene-Jean Bensadoun, Andrei Barasch   +2 more
exaly