Results 11 to 20 of about 2,589 (171)

Protein Lactylation in Cancer: Mechanisms and Therapeutic Targets [PDF]

MedComm
The Warburg effect states that cancer cells preferentially undergo aerobic glycolysis, producing lactate as a key metabolic byproduct. Lactate acidifies the tumor microenvironment (TME) and serves as a signaling molecule and substrate for lysine ...
Qianying Ouyang, Qianyu Hu, Caiqin Wang, Yizi He, Ruolan Zeng, Yajun Li, Chang Su, Guige Lu, Xueting Zhu, Ling Xiao, Hui Zhou   +10 more
doaj   +3 more sources

The TRIM33 Bromodomain Recognizes Histone Lysine Lactylation. [PDF]

ACS Chem Biol
Histone lysine lactylation (Kla) regulates inflammatory gene expression in activated macrophages and mediates the polarization of inflammatory (M1) to reparative (M2) macrophages. However, the molecular mechanisms and key protein players involved in Kla-mediated transcriptional changes are unknown.
Nuñez R, Sidlowski PFW, Steen EA, Wynia-Smith SL, Sprague DJ, Keyes RF, Smith BC.   +6 more
europepmc   +3 more sources

Systematic identification of the lysine lactylation in the protozoan parasite Toxoplasma gondii. [PDF]

Parasit Vectors, 2022
Abstract Background Lysine lactylation (Kla) is a novelposttranslational modification (PTM) identified in histone and nonhistone proteins of several eukaryotic cells that directly activates gene expression and DNA replication.
Zhao W, Yu H, Liu X, Wang T, Yao Y, Zhou Q, Zheng X, Tan F.   +7 more
europepmc   +4 more sources

Systematic analysis of lysine lactylation in nucleus pulposus cells. [PDF]

iScience
Nucleus pulposus (NP) resides in hypoxic microenvironment and NP cells (NPCs), primarily reply on glycolysis and producing high levels of lactate. Intracellular lactate drives lysine lactylation (Kla) as a newly epigenetic modification. However, the impact of Kla on NPCs remains unknown.
Sheng L, Xu H, Wang Y, Ni J, Xiang T, Xu H, Zhou X, Wei K, Dai J.   +8 more
europepmc   +4 more sources

Lysine lactylation (Kla) might be a novel therapeutic target for breast cancer. [PDF]

BMC Med Genomics, 2023
Abstract Background Histone lysine lactylation (Kla) is a newly identified histone modification, which plays a crucial role in cancer progression. Hence, we determined the prognostic value of Kla in breast cancer (BC). Methods We obtained RNA expression profiles of BC from ...
Deng J, Liao X.
europepmc   +4 more sources

Role of lysine lactylation in neoplastic and inflammatory pulmonary diseases (Review). [PDF]

Int J Mol Med
Protein lysine lactylation is a ubiquitous and post‑translational modification of lysine residues that involves the addition of a lactyl group on both histone and non‑histone proteins. This process plays a pivotal role in human health and disease and was first discovered in 2019.
Wang S, Zheng H, Zhao J, Xie J.
europepmc   +3 more sources

Systematic Analysis of Lysine Lactylation in the Plant Fungal Pathogen Botrytis cinerea. [PDF]

Front Microbiol, 2020
Lysine lactylation (Kla) is a newly discovered histone post-translational modification (PTM), playing important roles in regulating transcription in macrophages. However, the extent of this PTM in non-histone proteins remains unknown. Here, we report the first proteomic survey of this modification in Botrytis cinerea, a destructive necrotrophic fungal ...
Gao M, Zhang N, Liang W.
europepmc   +5 more sources

PBertKla: a protein large language model for predicting human lysine lactylation sites. [PDF]

BMC Biol
Lactylation is a newly discovered type of post-translational modification, primarily occurring on lysine (K) residues of both histones and non-histones to exert diverse effects on target proteins. Research has shown that lysine lactylation (Kla) modification is ubiquitous in different cells and participates in the determination of cell function and ...
Lai H, Luo D, Yang M, Zhu T, Yang H, Luo X, Wei Y, Xie S, Hong F, Shu K, Dao F, Ding H.   +11 more
europepmc   +4 more sources

Lysine Lactylation of Hemoglobin Promotes Oxygen Release in Red Blood Cells. [PDF]

ACS Omega
Hemoglobin oxygen affinity (HOA) increases during the storage of red blood cells (RBCs), which hinders the oxygen-release efficacy after transfusion. RBCs stored in alkaline preservation solution promote glycolysis and its final product lactate, which is an allosteric regulator of HOA.
Sheng M, Jin H, Tao S, You G, Li W, Chang C, Wang Y, Zhao L, Zhou H.   +8 more
europepmc   +3 more sources

Proanthocyanidins Ameliorate LPS-Inhibited Osteogenesis of PDLSCs by Restoring Lysine Lactylation. [PDF]

Int J Mol Sci
Periodontitis is a bacteria-induced inflammatory disease characterized by the progressive destruction of periodontal supporting tissues. Periodontal ligament stem cells (PDLSCs) are capable of differentiating into osteoblasts, which is an important stem cell source for endogenous periodontal tissue regeneration. Lysine lactylation (Kla) is a novel post-
Wu Y, Wang X, Zhang Y, Wen Z, Li Y, Zhang K, Gosar N, Li Q, Mao J, Gong S.   +9 more
europepmc   +3 more sources