Results 21 to 30 of about 2,589 (171)

HBO1 catalyzes lysine lactylation and mediates histone H3K9la to regulate gene transcription. [PDF]

Nat Commun
AbstractLysine lactylation (Kla) links metabolism and gene regulation and plays a key role in multiple biological processes. However, the regulatory mechanism and functional consequence of Kla remain to be explored. Here, we report that HBO1 functions as a lysine lactyltransferase to regulate transcription.
Niu Z, Chen C, Wang S, Lu C, Wu Z, Wang A, Mo J, Zhang J, Han Y, Yuan Y, Zhang Y, Zang Y, He C, Bai X, Tian S, Zhai G, Wu X, Zhang K.   +17 more
europepmc   +4 more sources

Dynamic changes in histone lysine lactylation during meiosis prophase I in mouse spermatogenesis. [PDF]

Proc Natl Acad Sci U S A
Male germ cells, which are responsible for producing millions of genetically diverse sperm through meiosis in the testis, rely on lactate as their central energy metabolite. Recent study has revealed that lactate induces epigenetic modification in cells through histone lysine lactylation. Here, we report dynamic histone lactylation at histone H4-lysine
Zhang X, Liu Y, Wang N.
europepmc   +3 more sources

Lactylated Proteomic Analysis Reveals Functional Implications of Lysine Lactylation In Asthenozoospermia. [PDF]

Mol Cell Proteomics
Yan M, Tu H, Tang S, Gai Z, Shi Q, Guo Y, Wang K, Xu X, Guo X, Li Y.   +9 more
europepmc   +2 more sources

Lactylation and tumor immune regulation: insights from recent studies [PDF]

Frontiers in Immunology
Lactate, a major product of glycolysis, accumulates abundantly in the tumor microenvironment (TME), serving not only as a hallmark of metabolic dysregulation but also as a key driver of immunosuppression.
Chunhong Li, Xiulin Jiang, Yixiao Yuan, Qiang Wang   +3 more
doaj   +2 more sources

Global Profiling of Lysine Lactylation in Prostate Cancer Cells. [PDF]

Cancer Genomics Proteomics
Kim JY, Sim H, Na AY, Choi SY, Lee S.
europepmc   +2 more sources

Global profiling of lysine lactylation in human lungs

PROTEOMICS, 2023
AbstractLactate is closely related to various cellular processes, such as angiogenesis, responses to hypoxia, and macrophage polarization, while regulating natural immune signaling pathways and promoting neurogenesis and cognitive function. Lysine lactylation (Kla) is a novel posttranslational modification, the examination of which may lead to new ...
Ye‐Hong Yang, Qiao‐Chu Wang, Jie Kong, Jun‐Tao Yang, Jiang‐Feng Liu   +4 more
openaire   +2 more sources

Protein Lactylation Critically Regulates Energy Metabolism in the Protozoan Parasite Trypanosoma brucei

Frontiers in Cell and Developmental Biology, 2021
Lysine lactylation has been recognized as a novel post-translational modification occurring on histones. However, lactylation in non-histone proteins, especially in proteins of early branching organisms, is not well understood.
Naiwen Zhang, Naiwen Zhang, Ning Jiang, Ning Jiang, Liying Yu, Liying Yu, Tiandong Guan, Tiandong Guan, Xiaoyu Sang, Xiaoyu Sang, Ying Feng, Ying Feng, Ran Chen, Ran Chen, Qijun Chen, Qijun Chen   +15 more
doaj   +1 more source

Identification of lysine-lactylated substrates in gastric cancer cells

iScience, 2022
Cancer cells tend to utilize aerobic glycolysis to generate energy and metabolites; the end product of aerobic glycolysis is lactate, which promotes lysine lactylation (Kla). Kla is a newly discovered histone post-translational modification (PTM) that plays important roles in regulating gene expression. However, Kla in non-histone mammalian proteins is
Dawei Yang, Jie Yin, Liuqun Shan, Xingling Yi, Wei Zhang, Yongbin Ding   +5 more
openaire   +3 more sources

Lysine l-lactylation is the dominant lactylation isomer induced by glycolysis [PDF]

Nature Chemical Biology
AbstractLysine l-lactylation (Kl-la) is a novel protein posttranslational modification (PTM) driven by l-lactate. This PTM has three isomers: Kl-la, N-ε-(carboxyethyl)-lysine (Kce) and d-lactyl-lysine (Kd-la), which are often confused in the context of the Warburg effect and nuclear presence. Here we introduce two methods to differentiate these isomers:
Di Zhang, Jinjun Gao, Zhijun Zhu, Qianying Mao, Zhiqiang Xu, Pankaj K. Singh, Cornelius C. Rimayi, Carlos Moreno-Yruela, Shuling Xu, Gongyu Li, Yi-Cheng Sin, Yue Chen, Christian A. Olsen, Nathaniel W. Snyder, Lunzhi Dai, Lingjun Li, Yingming Zhao   +16 more
openaire   +3 more sources

Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells

iScience
Summary: Aerobic glycolysis is a pivotal hallmark of cancers, including colorectal cancer. Evidence shows glycolytic enzymes are regulated by post-translational modifications (PTMs), thereby affecting the Warburg effect and reprograming cancer metabolism.
Zhe Cheng, Huichao Huang, Maoyu Li, Yongheng Chen   +3 more
doaj   +1 more source