A Multi‐Organ Atlas Links Gut Microbial Metabolites to Systemic Redox Changes in Aging Mice
Aging Cell, Volume 25, Issue 3, March 2026.A gut‐derived metabolic signature drives systemic aging phenotypes. Integrated multi‐omics profiling of young versus aged mice identifies a conserved aging signature characterized by the depletion of protective lysophosphatidylcholines (LPC 22:0) and the concurrent accumulation of pro‐oxidative microbial catabolites (TMAO, IAA).
Sanaullah Sajid +6 more
wiley +1 more source
Genotypic Variation in Wheat Flour Lysophospholipids
Molecules, 2017 Lysophospholipids (LPLs) are the most abundant polar lipids in wheat endosperm and naturally complex with amylose, affecting starch physicochemical properties.
Lei Liu +6 more
doaj +1 more source
Metabolism of polyunsaturated fatty acids in human bone marrow derived mesenchymal stromal cells [PDF]
, 2017 The application of human bone marrow derived mesenchymal stromal cells (hBMSCs) for regenerative or immunomodulatory therapies, e.g. treatment of the graft-versus-host disease, requires in vitro expansion of the cells.
Tigistu-Sahle, Feven
core
Snake and spider toxins induce a rapid recovery of function of botulinum neurotoxin paralysed neuromuscular junction [PDF]
, 2015 Botulinum neurotoxins (BoNTs) and some animal neurotoxins (-Bungarotoxin, -Btx, from elapid snakes and -Latrotoxin, -Ltx, from black widow spiders) are pre-synaptic neurotoxins that paralyse motor axon terminals with similar clinical outcomes in patients.
Duregotti, Elisa +6 more
core +2 more sources
FEBS Open Bio, 2016 Lysophophatidylcholine (LysoPC) is an abundant constituent in human plasma. Patients with malignant cancer diseases have attenuated LysoPC plasma levels, and thus LysoPC has been examined as a metabolic biomarker for cancer prediction.
Thomas Ross +6 more
doaj +1 more source
Sphingosine Phosphate Lyase Expression Is Essential for Normal Development in Caenorhabditis elegans [PDF]
, 2003 Sphingolipids are ubiquitous membrane constituents whose metabolites function as signaling molecules in eukaryotic cells. Sphingosine 1-phosphate, a key sphingolipid second messenger, regulates proliferation, motility, invasiveness, and programmed cell ...
Fyrst, Henrik +3 more
core +1 more source
Unfolding and refolding of cytochrome c driven by the interaction with lipid micelles [PDF]
, 2000 Binding of native cyt c to L-PG micelles leads to a partially unfolded conformation of cyt c. This micelle-bound state has no stable tertiary structure, but remains as -helical as native cyt c in solution.
Sanghera, Narinder +1 more
core +1 more source
Lysophospholipid interactions with protein targets [PDF]
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2008 Bioactive lysophospholipids include lysophosphatidic acid (LPA), sphingosine 1-phosphate (S1P), cyclic-phosphatidic acid (CPA) and alkyl glycerolphosphate (AGP). These lipid mediators stimulate a variety of responses that include cell survival, proliferation, migration, invasion, wound healing, and angiogenesis.
openaire +2 more sources
The Effect of Different Lysophospholipid Levels on Blood and Milk Biochemical Parameters, Liver and Rumen Enzymes, and Rumen Microbial Population in Early Lactation of Holstein Dairy Cows [PDF]
پژوهشهای تولیدات دامیExtended Abstract Background: High-yielding cows, especially at the beginning of the lactation period, are mainly in a negative energy balance. This problem occurs due to energy consumption less than the requirements for high production, which causes the
Matin Movagharnezhad +3 more
doaj
Deficiency of autotaxin/lysophospholipase D results in head cavity formation in mouse embryos through the LPA receptor-Rho-ROCK pathway [PDF]
, 2010 Autotaxin, encoded by the Enpp2 gene, generates lysophosphatidic acid (LPA) extracellularly, eliciting various cellular responses through specific LPA receptors.
Keino-Masu Kazuko +4 more
core +1 more source