Identification of ApoA4 as a sphingosine 1-phosphate chaperone in ApoM- and albumin-deficient mice
Journal of Lipid Research, 2019 HDL-bound ApoM and albumin are protein chaperones for the circulating bioactive lipid, sphingosine 1-phosphate (S1P); in this role, they support essential extracellular S1P signaling functions in the vascular and immune systems. We previously showed that
Hideru Obinata +9 more
doaj +1 more source
Requirement for sphingosine kinase 1 in mediating phase 1 of the hypotensive response to anandamide in the anaesthetised mouse [PDF]
, 2019 In the isolated rat carotid artery, the endocannabinoid anandamide induces endothelium-dependent relaxation via activation of the enzyme sphingosine kinase (SK).
Alganga, Husam +10 more
core +2 more sources
Secretory Phospholipases A2 in Plants [PDF]
, 2019 Secreted phospholipases (sPLA2s) in plants are a growing group of enzymes that catalyze the hydrolysis of sn-2 glycerophospholipids to lysophospholipids and free fatty acids. Until today, around only 20 sPLA2s were reported from plants.
Fidelio, Gerardo Daniel +1 more
core +1 more source
Involvement of lipid rafts in the localization and dysfunction effect of the antitumor ether phospholipid edelfosine in mitochondria [PDF]
, 2011 This work is licensed under the Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 Unported License.-- et al.Lipid rafts and mitochondria are promising targets in cancer therapy.
Acuña, A. Ulises +7 more
core +1 more source
Proliferative glioblastoma cancer cells exhibit persisting temporal control of metabolism and display differential temporal drug susceptibility in chemotherapy [PDF]
, 2019 Even in immortalized cell lines, circadian clocks regulate physiological processes in a time-dependent manner, driving transcriptional and metabolic rhythms, the latter being able to persist without transcription.
Gaveglio, Virginia Lucía +6 more
core +1 more source
SnapShot: Bioactive Lysophospholipids
Cell, 2012 Lysophosphatidic acid (LPA; monoacyl-glycerol-3-phosphate) and sphingosine 1-phosphate (S1P) are bioactive lysophospholipids that regulate critical biological functions and disease processes. LPA and S1P act on distinct G protein-coupled receptors (GPCRs) that initiate multiple signaling cascades in many cell types.
Moolenaar, Wouter H., Hla, Timothy
openaire +2 more sources
Journal of Lipid Research, 2019 Lysophosphatidylcholine (LPC) may accumulate in the heart to cause fibrotic events, which is mediated through fibroblast activation and collagen accumulation.
Hui-Ching Tseng +3 more
doaj +1 more source
Involvement of raft aggregates enriched in Fas/CD95 death-inducing signaling complex in the antileukemic action of edelfosine in Jurkat cells [PDF]
, 2012 [Background]: Recent evidence suggests that co-clustering of Fas/CD95 death receptor and lipid rafts plays a major role in death receptor-mediated apoptosis.
Gajate, Consuelo +2 more
core +2 more sources
Shedding new light on lipid biology with coherent anti-Stokes Raman scattering microscopy
Journal of Lipid Research, 2010 Despite the ubiquitous roles of lipids in biology, the detection of lipids has relied on invasive techniques, population measurements, or nonspecific labeling. Such difficulties can be circumvented by a label-free imaging technique known as coherent anti-
Thuc T. Le, Shuhua Yue, Ji-Xin Cheng
doaj +1 more source
Second trimester inflammatory and metabolic markers in women delivering preterm with and without preeclampsia. [PDF]
, 2019 ObjectiveInflammatory and metabolic pathways are implicated in preterm birth and preeclampsia. However, studies rarely compare second trimester inflammatory and metabolic markers between women who deliver preterm with and without preeclampsia.Study ...
A Chaparro +46 more
core +1 more source