Results 21 to 30 of about 10,942 (204)

Functional Characterization of Lysophospholipids by Proteomic and Lipidomic Analysis of Fibroblast-like Synoviocytes

Cells, 2023
Synovial fluid (SF) from human knee joints with osteoarthritis (OA) has elevated levels of lysophosphatidylcholine (LPC) species, but their functional role is not well understood.
Thomas Timm, Christiane Hild, Gerhard Liebisch, Markus Rickert, Guenter Lochnit, Juergen Steinmeyer   +5 more
doaj   +1 more source

Secretory Phospholipases A2 in Plants [PDF]

, 2019
Secreted phospholipases (sPLA2s) in plants are a growing group of enzymes that catalyze the hydrolysis of sn-2 glycerophospholipids to lysophospholipids and free fatty acids. Until today, around only 20 sPLA2s were reported from plants.
Fidelio, Gerardo Daniel, Mariani, Maria Elisa   +1 more
core   +1 more source

Involvement of lipid rafts in the localization and dysfunction effect of the antitumor ether phospholipid edelfosine in mitochondria [PDF]

, 2011
This work is licensed under the Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 Unported License.-- et al.Lipid rafts and mitochondria are promising targets in cancer therapy.
Acuña, A. Ulises, Amat-Guerri, Francisco, Delgado, Javier, Gajate, Consuelo, Hornillos, Valentín, Mollinedo, Faustino, Nieto-Miguel, Teresa, Villa-Pulgarín, J. A.   +7 more
core   +1 more source

Platelet interaction with bioactive lipids formed by mild oxidation of low-density lipoprotein [PDF]

, 2006
Oxidation of low-density lipoprotein (LDL) generates pro-inflammatory and pro-thrombotic mediators that play a crucial role in cardiovascular and inflammatory diseases.
Siess, Wolfgang
core   +1 more source

SnapShot: Bioactive Lysophospholipids

Cell, 2012
Lysophosphatidic acid (LPA; monoacyl-glycerol-3-phosphate) and sphingosine 1-phosphate (S1P) are bioactive lysophospholipids that regulate critical biological functions and disease processes. LPA and S1P act on distinct G protein-coupled receptors (GPCRs) that initiate multiple signaling cascades in many cell types.
Moolenaar, Wouter H., Hla, Timothy
openaire   +2 more sources

Lysophosphatidylcholine-induced mitochondrial fission contributes to collagen production in human cardiac fibroblasts[S]

Journal of Lipid Research, 2019
Lysophosphatidylcholine (LPC) may accumulate in the heart to cause fibrotic events, which is mediated through fibroblast activation and collagen accumulation.
Hui-Ching Tseng, Chih-Chung Lin, Li-Der Hsiao, Chuen-Mao Yang   +3 more
doaj   +1 more source

Second trimester inflammatory and metabolic markers in women delivering preterm with and without preeclampsia. [PDF]

, 2019
ObjectiveInflammatory and metabolic pathways are implicated in preterm birth and preeclampsia. However, studies rarely compare second trimester inflammatory and metabolic markers between women who deliver preterm with and without preeclampsia.Study ...
A Chaparro, AO Odibo, B Bolar, B Sibai, BD Taylor, Christina Chambers, Christine Dunkel Schetter, DA Enquobahrie, E Turner, Elena Flowers, F Faul, Gretchen Bandoli, H Luan, H Zeisler, J Massé, J Pinto, JE Ramsay, KE Innes, Kelli Ryckman, Kharah M. Ross, KK Ferguson, KM Ross, Laura Jelliffe-Pawlowski, LC Kenny, Liang Liang, LL Jelliffe-Pawlowski, M Austdal, M Swellam, MP Koster, N Visser, R Boij, R Romero, Rebecca J. Baer, RJ Levine, RO Bahado-Singh, S Acikgoz, S Kim, S Kuc, S Schott, Scott Oltman, Sky K. Feuer, SO Diaz, SW Walsh, SW Walsh, T Chaiworapongsa, T Chen, T Nagamatsu   +46 more
core   +1 more source

Quantification and Localisation of New Brain Lipid Synthesis Using Deuterium Oxide and High Resolution Mass Spectrometry

Angewandte Chemie, EarlyView.
Liquid chromatography tandem mass spectrometry and mass spectrometry imaging were used in combination with deuterium oxide administration to quantify and localise newly synthesised myelin lipids in the mouse brain. This methodology, used here to show sites of myelin repair, enables the measurement of dynamic lipid synthesis in living systems and ...
Catherine Zhang, Jesse A. Michael, Jonathan D. Teo, Huitong Song, Mika T. Westerhausen, Shadrack M. Mutuku, Shane R. Ellis, Anthony S. Don   +7 more
wiley   +2 more sources

Updating Phospholipase A₂ Biology

Biomolecules, 2020
The phospholipase A2 (PLA2) superfamily contains more than 50 enzymes in mammals that are subdivided into several distinct families on a structural and biochemical basis.
Makoto Murakami, Hiroyasu Sato, Yoshitaka Taketomi   +2 more
doaj   +1 more source

Involvement of raft aggregates enriched in Fas/CD95 death-inducing signaling complex in the antileukemic action of edelfosine in Jurkat cells [PDF]

, 2012
[Background]: Recent evidence suggests that co-clustering of Fas/CD95 death receptor and lipid rafts plays a major role in death receptor-mediated apoptosis.
Gajate, Consuelo, González-Camacho, Fernando, Mollinedo, Faustino   +2 more
core   +2 more sources