Results 51 to 60 of about 11,072 (207)

Advancing design strategies in smart stimulus‐responsive liposomes for drug release and nanomedicine

BMEMat, EarlyView.
Schematic illustration of stimulus‐responsive liposomes designed for controlled drug release and nanomedicine. The innermost circle represents different liposomal structures, including unilamellar, multilamellar, and multivesicular liposomes. The middle layer illustrates the responsive phospholipid components.
Yuchen Guo, Nan Li, Daiwei Zhang, Jingya Gu, Zhihuan Liao, Zihao Teng, Xiangfu Du, Peter S. Timashev, Shipeng Chen, Shuaidong Huo   +9 more
wiley   +1 more source

Phospholipase A2 products influence the antiplatelet functions of synthetic high-density lipoproteins

Journal of Lipid Research
Multiple synthetic high-density lipoproteins (sHDLs) have been developed and extensively evaluated in preclinical and clinical trials, with their functionality potentially linked to specific lipid compositions.
Antonela Rodriguez, Minzhi Yu, Jingyao Gan, May Thazin Phoo, Alankrita Rani, Gunther Marsche, Yanhong Guo, Michael Holinstat, Anna Schwendeman   +8 more
doaj   +1 more source

A single amino acid determines preference between phospholipids and reveals length restriction for activation ofthe S1P₄ receptor [PDF]

, 2004
Background<br/><br/> Sphingosine-1-phosphate and lysophosphatidic acid (LPA) are ligands for two related families of G protein-coupled receptors, the S1P and LPA receptors, respectively.
Fells, J.I., Holdsworth, G., Hutchinson, G., Milligan, G., Osborne, D.A., Parrill, A.L., Thi Pham, T.   +6 more
core   +3 more sources

Lysophospholipid receptors in drug discovery [PDF]

Experimental Cell Research, 2015
Lysophospholipids (LPs), including lysophosphatidic acid (LPA), sphingosine 1-phospate (S1P), lysophosphatidylinositol (LPI), and lysophosphatidylserine (LysoPS), are bioactive lipids that transduce signals through their specific cell-surface G protein-coupled receptors, LPA1-6, S1P1-5, LPI1, and LysoPS1-3, respectively.
Yasuyuki, Kihara, Hirotaka, Mizuno, Jerold, Chun   +2 more
openaire   +2 more sources

Metabolic abnormalities and reprogramming in cats with naturally occurring hypertrophic cardiomyopathy

ESC Heart Failure, Volume 12, Issue 2, Page 1256-1270, April 2025.
Abstract Background and aims The heart is a metabolic organ rich in mitochondria. The failing heart reprograms to utilize different energy substrates, which increase its oxygen consumption. These adaptive changes contribute to increased oxidative stress.
Qinghong Li, Max Homilius, Erin Achilles, Laura K. Massey, Victoria Convey, Åsa Ohlsson, Ingrid Ljungvall, Jens Häggström, Brittany Vester Boler, Pascal Steiner, Sharlene Day, Calum A. MacRae, Mark A. Oyama   +12 more
wiley   +1 more source

Updating Phospholipase A₂ Biology

Biomolecules, 2020
The phospholipase A2 (PLA2) superfamily contains more than 50 enzymes in mammals that are subdivided into several distinct families on a structural and biochemical basis.
Makoto Murakami, Hiroyasu Sato, Yoshitaka Taketomi   +2 more
doaj   +1 more source

Gut microbiome‐derived metabolites show promise in cancer research and therapy

Interdisciplinary Medicine, EarlyView.
The metabolites produced by the gut microbiome, which are subject to regulation by multiple factors, play a pivotal role in the progression of various types of cancer. These metabolites not only function as potential biomarkers for the early detection and monitoring of tumor development, but also actively participate in cancer therapeutic processes ...
Kangjie Yang, Yifan Wang, Daolin Tang, Peilong Li, Lutao Du   +4 more
wiley   +1 more source

The patatin-containing phospholipase A pPLAIIα modulates oxylipin formation and water loss in Arabidopsis thaliana [PDF]

, 2012
The patatin-related phospholipase A (pPLA) hydrolyzes membrane glycerolipids to produce monoacyl compounds and free fatty acids. Phospholipids are cleaved by pPLAIIα at the sn-1 and sn-2 positions, and galactolipids, including those containing ...
Bahn, Sung Chul, Hong, Yue-Yun, Li, Mao-Yin, Pan, Xiang-Qing, Roth, Mary R., Scheu, Brad, Vu, Hieu Sy, Wang, Xue-Min, Welti, Ruth, Yang, Wen-Yu, Zheng, Yong   +10 more
core   +1 more source

Smart Biomaterials and Dressings for the Treatment of Chronic Inflammatory Skin Diseases

Rare Metals, EarlyView.
ABSTRACT Chronic inflammatory skin diseases, encompassing immune‐inflammatory conditions and infection‐associated dermatoses, pose significant clinical challenges due to high prevalence, recurrence, and therapeutic resistance, affect over 30% of the global population.
Zehao Lan, Shengjie Xue, Junyi Yin, Shaolei Wang, Yunlei Zhou, Jieyue Liao   +5 more
wiley   +1 more source

A starch edible surface coating delays banana fruit ripening [PDF]

, 2019
A rice starch edible coating blended with sucrose esters was developed for controlling the postharvest physiological activity of Cavendish banana to extend postharvest quality during ripening at 20 ± 2 °C.
Bowyer, Michael, Pristijono, Penta, Scarlett, Christopher J., Singh, Sukhvinder P., Stathopoulos, Costas E., Thakur, Rahul, Vuong, Quan V.   +6 more
core   +2 more sources