Results 161 to 170 of about 10,818 (180)
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Dysregulation of the Epitranscriptomic Mark m1A in Ischemic Stroke
Translational Stroke Research, 2022Methylation of adenosine at N1 position yields N1-methyladenosine (m1A), which is an epitranscriptomic modification that regulates mRNA metabolism. Recent studies showed that altered m1A methylation promotes acute and chronic neurological diseases. We currently evaluated the effect of focal ischemia on cerebral m1A methylome and its machinery.
Anil K, Chokkalla +6 more
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Cell Chemical Biology
CAG-repeat expansions underlie fatal neurodegenerative disorders. In a lodestar study published in a recent issue of Nature, Sun et al.1 identify a writer and eraser of N1-methyladenosine (m1A) modifications of CAG-repeat RNA. They establish that m1A modifications in CAG-repeat expanded RNA promote neurodegeneration and aberrant phase transitions of ...
Linamarie, Miller, James, Shorter
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CAG-repeat expansions underlie fatal neurodegenerative disorders. In a lodestar study published in a recent issue of Nature, Sun et al.1 identify a writer and eraser of N1-methyladenosine (m1A) modifications of CAG-repeat RNA. They establish that m1A modifications in CAG-repeat expanded RNA promote neurodegeneration and aberrant phase transitions of ...
Linamarie, Miller, James, Shorter
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, 1987 An examination of the compositional changes in the monetary aggregates M1 and M1A, with a discussion of their behavior in the 1980s and some issues relevant to the possibility of replacing M1 with M1A in the monetary targeting framework.
William T. Gavin, Michael R. Pakko
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, 2004 This work analyzes, from an empirical standpoint, the information contained in the M1A aggregate in Chile and compares it with other aggregates. The findings reveal that, at least for now, the M1A aggregate does not seem to have particularly valuable information that would make it a better indicator of inflationary pressures within the monetary policy ...
Pablo García,, Rodrigo O. Valdés
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tRNA-m1A modification promotes T cell expansion via efficient MYC protein synthesis
Nature Immunology, 2022Naive T cells undergo radical changes during the transition from dormant to hyperactive states upon activation, which necessitates de novo protein production via transcription and translation. However, the mechanism whereby T cells globally promote translation remains largely unknown.
Yongbo Liu +19 more
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Mapping m6A and m1A with mutation signatures
Nature Methods, 2019In two novel RNA modification mapping methods, the authors have engineered RNA enzymes and used the enzyme-mediated mutational signatures to map m6A and m1A at single-nucleotide resolution in mammalian RNA.
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The m1A landscape on cytosolic and mitochondrial mRNA at single-base resolution
Nature, 2017Modifications on mRNA offer the potential of regulating mRNA fate post-transcriptionally. Recent studies suggested the widespread presence of N1-methyladenosine (m1A), which disrupts Watson-Crick base pairing, at internal sites of mRNAs. These studies lacked the resolution of identifying individual modified bases, and did not identify specific sequence
Safra, Modi +9 more
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m1A tRNA modification facilitates rapid T cell proliferation
Nature Immunology, 2022openaire +2 more sources
tRNA-m1A modification: a translational checkpoint for T cell expansion
Cell Research, 2022Weike Pei, Vijay K. Kuchroo
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