Results 181 to 190 of about 8,119 (209)

Emerging Role of RNA m5C Modification in Cardiovascular Diseases

Journal of Cardiovascular Translational Research, 2022
Epitranscriptomics is the emerging field of research that comprises the study of epigenetics changes in RNAs. Progressing development in the field of epigenetics has helped to manage and comprehend human diseases. RNA methylation regulates all aspects of RNA functions, which are involved in the pathogenesis of human diseases.
Kannan, Balachander, Jayaseelan Vijayashree, Priyadharsini, Anitha, Roy, Arumugam, Paramasivam   +3 more
openaire   +2 more sources

mRNA m5C controls adipogenesis by promoting CDKN1A mRNA export and translation

RNA Biology, 2021
5-Methylcytosine (m5C) is a type of RNA modification that exists in tRNAs and rRNAs and was recently found in mRNA. Although mRNA m5C modification has been reported to regulate diverse biological process, its function in adipogenesis remains unknown.
Yuanling Zhao, Yushi Chen, Xinxia Wang   +2 more
exaly   +3 more sources

m5C mRNAs on the move

Nature Reviews Molecular Cell Biology, 2019
Cytosine methylation (m5C) in mRNAs is important for their transport to distant tissues in plants.
openaire   +2 more sources

Recent insights into RNA m5C methylation modification in hepatocellular carcinoma

Biochimica Et Biophysica Acta: Reviews on Cancer
RNA 5-methylcytosine (m5C) methylation involves the addition of a methyl (-CH3) group to the cytosine (C) base within an RNA molecule, forming the m5C modification. m5C plays a role in numerous essential biological processes, including the regulation of RNA stability, nuclear export, and protein translation.
Mingyu He
exaly   +3 more sources

The emerging role of m5C modification in viral infection

Virology
5-Methylcytosine (m5C) modification is a dynamic and reversible post-transcriptional process that has garnered significant attention due to its regulatory role in viral infections and host innate immune responses. Advances in m5C detection technologies have spurred research into its influence on viral infection pathways.
Jincheng Li, Leiliang Zhang
openaire   +2 more sources

YccW is the m5C Methyltransferase Specific for 23S rRNA Nucleotide 1962

Journal of Molecular Biology, 2008
Methylation at the 5-position of cytosine [m(5)C (5-methylcytidine)] occurs at three RNA nucleotides in Escherichia coli. All these modifications are at highly conserved nucleotides in the rRNAs, and each is catalyzed by its own m(5)C methyltransferase enzyme.
Purta, Elzbieta, O'Connor, Michelle, Bujnicki, Janusz M, Douthwaite, Stephen   +3 more
openaire   +2 more sources

NOP2-mediated m5C methylation of XPD is associated with hepatocellular carcinoma progression

Neoplasma, 2023
Hepatocellular carcinoma (HCC) is a common malignant tumor with high mortality. Our previous study has confirmed that XPD acts as an anti-oncogene and is downregulated in HCC. The mechanism of XPD downregulation in HCC is unclear. In this work, we obtained the datasets related to HCC patients from GSE76427, LIRI-JP, and TCGA-LIHC cohorts.
Guo-Fang, Sun, Hao, Ding
openaire   +2 more sources

NSUN2-Mediated m5C Methylation Impairs Endometrial Receptivity

Laboratory Investigation
Impaired endometrial decidualization is the primary cause of recurrent implantation failure (RIF). RNA methylation modification, especially NSUN family mediated m5C, is crucial for various physiological events, such as maternal-to-zygotic transition, gametogenesis, embryonic development, organismal lifespan, and cell cycle.
Jiafeng Lu, Ming Zhang, Zhenxing Liu, Ling Guo, Peng Huang, Wenjuan Xia, Jincheng Li, Jinghuan Lv, Hoi-Hung Cheung, Chenyue Ding, Hong Li, Boxian Huang   +11 more
openaire   +2 more sources

Dynamic landscape and regulation of m5C methylation in human tissues

Science China Life Sciences
5-methylcytosine (m5C) is a prevalent RNA modification that has various impacts on mRNA fate. Here, we generated 30 single-base resolution RNA m5C methylomes and revealed the dynamic nature of m5C of heart, muscle, lung, esophagus, stomach, pancreas, colon, jejunum, and rectum from 7 adult human individuals using RNA-BisSeq.
Ke, An, Ruijuan, Liu, Han, Yang, Luyao, Feng, Xinhan, Zhang, Xuran, Zhang, Mingyang, Hou, Jingyao, Wei, Xiao, Han, Boyang, Shi, Huan, Yao, Xing, Chen, Han, Wang, Xin, Tian   +13 more
openaire   +2 more sources

YebU is a m5C Methyltransferase Specific for 16 S rRNA Nucleotide 1407

Journal of Molecular Biology, 2006
The rRNAs in Escherichia coli contain methylations at 24 nucleotides, which collectively are important for ribosome function. Three of these methylations are m5C modifications located at nucleotides C967 and C1407 in 16S rRNA and at nucleotide C1962 in 23S rRNA.
Andersen, Niels Møller, Douthwaite, Stephen   +1 more
openaire   +3 more sources