Results 191 to 200 of about 11,326 (215)

The emerging role of m5C modification in viral infection

Virology
5-Methylcytosine (m5C) modification is a dynamic and reversible post-transcriptional process that has garnered significant attention due to its regulatory role in viral infections and host innate immune responses. Advances in m5C detection technologies have spurred research into its influence on viral infection pathways.
Jincheng Li, Leiliang Zhang
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YccW is the m5C Methyltransferase Specific for 23S rRNA Nucleotide 1962

Journal of Molecular Biology, 2008
Methylation at the 5-position of cytosine [m(5)C (5-methylcytidine)] occurs at three RNA nucleotides in Escherichia coli. All these modifications are at highly conserved nucleotides in the rRNAs, and each is catalyzed by its own m(5)C methyltransferase enzyme.
Purta, Elzbieta, O'Connor, Michelle, Bujnicki, Janusz M, Douthwaite, Stephen   +3 more
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NOP2-mediated m5C methylation of XPD is associated with hepatocellular carcinoma progression

Neoplasma, 2023
Hepatocellular carcinoma (HCC) is a common malignant tumor with high mortality. Our previous study has confirmed that XPD acts as an anti-oncogene and is downregulated in HCC. The mechanism of XPD downregulation in HCC is unclear. In this work, we obtained the datasets related to HCC patients from GSE76427, LIRI-JP, and TCGA-LIHC cohorts.
Guo-Fang, Sun, Hao, Ding
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NSUN2-Mediated m5C Methylation Impairs Endometrial Receptivity

Laboratory Investigation
Impaired endometrial decidualization is the primary cause of recurrent implantation failure (RIF). RNA methylation modification, especially NSUN family mediated m5C, is crucial for various physiological events, such as maternal-to-zygotic transition, gametogenesis, embryonic development, organismal lifespan, and cell cycle.
Jiafeng Lu, Ming Zhang, Zhenxing Liu, Ling Guo, Peng Huang, Wenjuan Xia, Jincheng Li, Jinghuan Lv, Hoi-Hung Cheung, Chenyue Ding, Hong Li, Boxian Huang   +11 more
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Recent insights into RNA m5C methylation modification in hepatocellular carcinoma

Biochimica Et Biophysica Acta: Reviews on Cancer
RNA 5-methylcytosine (m5C) methylation involves the addition of a methyl (-CH3) group to the cytosine (C) base within an RNA molecule, forming the m5C modification. m5C plays a role in numerous essential biological processes, including the regulation of RNA stability, nuclear export, and protein translation.
Danyang, Li, Yanyan, Liu, Guang, Yang, Mingyu, He, Ligong, Lu   +4 more
exaly   +3 more sources

Dynamic landscape and regulation of m5C methylation in human tissues

Science China Life Sciences
5-methylcytosine (m5C) is a prevalent RNA modification that has various impacts on mRNA fate. Here, we generated 30 single-base resolution RNA m5C methylomes and revealed the dynamic nature of m5C of heart, muscle, lung, esophagus, stomach, pancreas, colon, jejunum, and rectum from 7 adult human individuals using RNA-BisSeq.
Ke, An, Ruijuan, Liu, Han, Yang, Luyao, Feng, Xinhan, Zhang, Xuran, Zhang, Mingyang, Hou, Jingyao, Wei, Xiao, Han, Boyang, Shi, Huan, Yao, Xing, Chen, Han, Wang, Xin, Tian   +13 more
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YebU is a m5C Methyltransferase Specific for 16 S rRNA Nucleotide 1407

Journal of Molecular Biology, 2006
The rRNAs in Escherichia coli contain methylations at 24 nucleotides, which collectively are important for ribosome function. Three of these methylations are m5C modifications located at nucleotides C967 and C1407 in 16S rRNA and at nucleotide C1962 in 23S rRNA.
Andersen, Niels Møller, Douthwaite, Stephen   +1 more
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RNA methylation and breast cancer: insights into m6A, m7G and m5C

Molecular Biology Reports
Breast cancer remains the most commonly diagnosed cancer in female worldwide, marked by its molecular diversity and complex subtypes. Despite progress in targeted therapies, tumor heterogeneity and treatment resistance continue to present major challenges. Recent studies emphasize the crucial role of RNA modifications in cancer biology, with nearly 200
Yuhan, Dai, Shuhan, Zhao, Huilin, Chen, Wenxin, Yu, Ziyi, Fu, Yangyang, Cui, Hui, Xie   +6 more
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The Role of RNA m5C Modification in Central Nervous System Diseases

Discovery Medicine
As advances in RNA modification research progress, the significance of 5-methylcytosine (m5C) modification is being increasingly acknowledged. m5C undergoes modification by the methyltransferase NOP2/Sun domain (NSUN) family/DNA methyltransferase (DNMT) family (writer) and is removed by demethylases (eraser), including the ten-eleven translocation (TET)
Peiyan, Wu, Jiaxiang, Gao, Guangming, Lan, Yichao, Wang   +3 more
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Identification of Human RNA m5C sites using CapsuleNet Architecture

2022 IEEE International Conference on Bioinformatics and Biomedicine (BIBM), 2022
Mobeen Ur Rehman, Zeeshan Abbas, Kil To Chong 0001   +2 more
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