Results 121 to 130 of about 26,139 (253)

Targeting Microbiome Metabolites: Reshaping Immunotherapy and Clinical Management Strategies for Colorectal Cancer

iMetaMed, EarlyView.
The occurrence and progression of colorectal cancer are intricately linked to metabolites produced by the gut microbiota. Metabolites generated by pathogenic microbial communities can promote colorectal cancer development by reshaping the immune microenvironment.
Xinrui Yang, Ke Zhang, Lijie Xia, Jinyao Li   +3 more
wiley   +1 more source

Malignant Evaluation and Clinical Prognostic Values of m6A RNA Methylation Regulators in Glioblastoma

Frontiers in Oncology, 2020
N6-methyladenosine (m6A) RNA methylation, the most common form of mRNA modification and regulated by the m6A RNA methylation regulators (“writers,” “erasers,” and “readers”), has been reported to be associated with the progression of the malignant tumor.
Jianyang Du, Jianyang Du, Kuiyuan Hou, Kuiyuan Hou, Shan Mi, Shan Mi, Hang Ji, Hang Ji, Shuai Ma, Shuai Ma, Yixu Ba, Yixu Ba, Shaoshan Hu, Rui Xie, Lei Chen, Lei Chen   +15 more
doaj   +1 more source

Altered expression of neuroplasticity-related genes in the brain of depressed suicides [PDF]

, 2015
Background: Expression of the neuronal membrane glycoprotein M6a (GPM6A), the proteolipid protein (PLP/DM20) family member, is downregulated in the hippocampus of chronically stressed animals.
Alvarez Juliá, Anabel, Frasch, Alberto Carlos C., Fuchsova, Beata, Pandey, G. N., Rizavi, H. S.   +4 more
core   +1 more source

m6A RNA methylation impacts fate choices during skin morphogenesis

eLife, 2020
N 6 -methyladenosine is the most prominent RNA modification in mammals. Here, we study mouse skin embryogenesis to tackle m6A’s functions and physiological importance. We first landscape the m6A modifications on skin epithelial progenitor mRNAs.
Linghe Xi, Thomas Carroll, Irina Matos, Ji-Dung Luo, Lisa Polak, H Amalia Pasolli, Samie R Jaffrey, Elaine Fuchs   +7 more
openaire   +3 more sources

Epigenetic Regulation in the Pathogenesis of Renal Inflammation: Insights and Therapeutic Potentials

iNew Medicine, EarlyView.
ABSTRACT Renal inflammation is a common pathological process in various kidney diseases, often initiated by factors such as toxins, ischemia, or autoimmune reactions. This inflammatory response can result in structural damage and a rapid decline in renal function.
Yu‐Hang Dong, Xiao‐Yu Shen, Han‐Cheng Jin, Xiang‐Yu Li, Hao He, Xiao‐Ming Meng   +5 more
wiley   +1 more source

Intelligent biology and medicine in 2015: advancing interdisciplinary education, collaboration, and data science [PDF]

, 2016
We summarize the 2015 International Conference on Intelligent Biology and Medicine (ICIBM 2015) and the editorial report of the supplement to BMC Genomics. The supplement includes 20 research articles selected from the manuscripts submitted to ICIBM 2015.
Jianhua Ruan, Kun Huang, Lang Li, Lee Cooper, Yufei Huang, Yunlong Liu, Zhongming Zhao   +6 more
core   +3 more sources

Insulin Resistance: An Update on Biochemical and Pathophysiological Mechanisms and Impact on Various Diseases

iNew Medicine, EarlyView.
ABSTRACT Insulin resistance is the biological phenomenon in which the human body's normal response to the metabolic hormone insulin is compromised. Insulin is a regulator of most of the essential metabolic steps in the body that control energy homoeostasis, so dysregulation leads to multiple diverse human diseases including, most prominently, Type 2 ...
Peter J. Little, Stefan Offermanns, Haaglim Cho, Zhiping Liu, Pinglian Yang, Qiaozhu Su, Henry Wade, Wah Yang, Danielle Kamato, Neale Cohen, Alex Bobik, Iqra Ilyas, Suowen Xu   +12 more
wiley   +1 more source

N6‐Methyladenosine (m6A) in Liver Disease: Pathogenic Mechanisms and Therapeutic Potential

iNew Medicine, EarlyView.
ABSTRACT Accumulating evidence highlights the critical role of epigenetic modifications, particularly N6‐methyladenosine (m6A), in liver disease. As the most abundant RNA modification in eukaryotic cells, m6A is dynamically regulated by multicomponent m6A methyltransferases (e.g., METTL3 and METTL14), demethylases (FTO and ALKBH5), and m6A‐binding ...
Yingfen Chen, Ru Ya, Ziling Zhang, Siyue Dong, Seol Hee Park, Wonhyo Seo, Yong He   +6 more
wiley   +1 more source

Identification of methylated deoxyadenosines in vertebrates reveals diversity in DNA modifications. [PDF]

, 2015
Methylation of cytosine deoxynucleotides generates 5-methylcytosine (m(5)dC), a well-established epigenetic mark. However, in higher eukaryotes much less is known about modifications affecting other deoxynucleotides. Here, we report the detection of N(6)-
A Morgulis, Ana S H Costa, BA Braaten, BF Vanyushin, C Zang, Charles R Bradshaw, Christian Frezza, D Dominissini, D Roberts, E Ford, EL Greer, EM Reyes, EM Zdobnov, F Laengle-Rouault, G Bertani, G Zhang, GE Geier, George E Allen, H Kobayashi, H Li, J Boyes, JB Bowes, John B Gurdon, KS Pollard, L Micallef, M Lawrence, M Lu, Magdalena J Koziol, MG Marinus, MS May, PA Jones, PD Lawley, PD Thomas, PH Kay, RD Hotchkiss, S Ito, SE Luria, T Pfaffeneder, TL Bailey, TW Munns, U Gunthert, WA Cantara, WJ Kent, Y Fu, Y Gruenbaum   +44 more
core   +2 more sources

Noncanonical Nucleotides in the Genome Around the Maternal‐Zygotic Transition

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
In this paper, Kazzazi et al. provide a comprehensive review of the dynamics of nonconventional nucleotides in the genome during early developmental stages, hypothesizing a potential role for these nucleotides in the activation of the zygotic genome. ABSTRACT From the very moment of fertilization and throughout development, the cells of animal embryos ...
Latifa Kazzazy, Dávid Mező, Kinga K. Nagy, Viktória Perey‐Simon, Judit Tóth, Angéla Békési, Beáta Vértessy, Máté Varga   +7 more
wiley   +1 more source