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The role and mechanism of m6A methylation in diabetic nephropathy
Life SciencesDiabetic nephropathy (DN) is one of the most common microvascular complications of diabetes mellitus, characterized by progressive deterioration of renal structure and function, which may eventually lead to end-stage kidney disease (ESKD). The N6-methyladenosine (m6A) methylation, an important modality of RNA modification, involves three classes of key
Linjing, Yan, Liang, Guo
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RNA m6A methylation at the juxtaposition of apoptosis and RNA therapeutics
Trends in Cell BiologyTargeting RNA m6A marks in apoptosis-related transcripts holds promise for RNA therapeutics. However, pathway-specific RNA m6A sites on pro- or antiapoptotic transcripts have not been fully unveiled, let alone characterized. This article summarizes the current knowledge and gaps in the cellular response modulated by apoptotic stimulus-specific RNA m6A ...
Bünyamin Akgül +2 more
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RNA m6A methylation in psychiatric disorders.
EC psychology and psychiatryThis comprehensive review introduces the features of m6A modification and its role in neuropsychiatric disorders. The research findings suggest that m6A modifications and their regulators play a critical role in the occurrence and development of major psychiatric disorders, especially Alzheimer's disease, affecting synaptic protein synthesis, subtype ...
Qiao, Mao +7 more
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Enhancer RNA m6A methylation facilitates transcriptional condensate formation and gene activation
Molecular Cell, 2021Joo-Hyung Lee, Fabio Stossi, Elena Moroz
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Stabilization of ERK-Phosphorylated METTL3 by USP5 Increases m6A Methylation
Molecular Cell, 2020Yawei Gao, Qili Fei, Allen C Zhu
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Emerging role of m6A RNA methylation in nutritional physiology and metabolism
Obesity Reviews, 2020Zhending Gan, Jingfei Zhang, Xiang Zhong
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Splice site m6A methylation prevents binding of U2AF35 to inhibit RNA splicing
Cell, 2021Florian A Steiner +2 more
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