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m6A RNA Methylation in Cardiovascular Diseases [PDF]

Molecular Therapy, 2020
Cardiovascular diseases (CVDs) remain the leading cause of death and disability worldwide, despite marked improvements in prevention, diagnosis, and early intervention. There is an urgent need to discover more effective therapeutic strategies, which would be facilitated by a more in-depth understanding of CVDs and their underlying molecular mechanisms.
Xiang Zhou, Shuchen Zhang, Xiaoguang Wu
exaly   +3 more sources

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Role of m6A methylation in retinal diseases

Experimental Eye Research, 2023
Retinal diseases remain among the leading causes of visual impairment in developed countries, despite great efforts in prevention and early intervention. Due to the limited efficacy of current retinal therapies, novel therapeutic methods are urgently required. Over the past two decades, advances in next-generation sequencing technology have facilitated
Xinyu Zhu, Chuandi Zhou, Shuzhi Zhao, Zhi Zheng   +3 more
openaire   +2 more sources

RNA m6A methylation regulators in sepsis

Molecular and Cellular Biochemistry, 2023
N6-methyladenosine (m6A) modification is a class of epitope modifications that has received significant attention in recent years, particularly in relation to its role in various diseases, including sepsis. Epigenetic research has increasingly focused on m6A modifications, which is influenced by the dynamic regulation of three protein types: ‟Writers" (
Lin, Zhu, Hairong, Zhang, Xiaoyu, Zhang, Lei, Xia   +3 more
openaire   +2 more sources

Temporal Control of Mammalian Cortical Neurogenesis by m6A Methylation [PDF]

Cell, 2017
N6-methyladenosine (m6A), installed by the Mettl3/Mettl14 methyltransferase complex, is the most prevalent internal mRNA modification. Whether m6A regulates mammalian brain development is unknown. Here, we show that m6A depletion by Mettl14 knockout in embryonic mouse brains prolongs the cell cycle of radial glia cells and extends cortical neurogenesis
Peng Jin, Francisca Rojas-Ringeling, Sergi Regot   +2 more
exaly   +3 more sources

m6A mRNA methylation: A pleiotropic regulator of cancer

Gene, 2020
In recent days, RNA modifications are gaining the interest of biologist worldwide. Till date, a total of 171 RNA modifications has been reported, and the number may increase with advancing technologies. The mRNA undergoes modifications like m5M, hm5C, m1A, m6A and pseudouridine, collectively called as epitranscriptomic alterations, each of them has ...
openaire   +2 more sources

Decoding m6A mRNA methylation by reader proteins in cancer

Cancer Letters, 2021
N6-methyladenosine (m6A), the most prevalent internal modification in eukaryotic mRNAs, regulates gene expression at the post-transcriptional level. The reader proteins of m6A, mainly YTH domain-containing proteins, specifically recognize m6A-modified mRNAs and regulate their metabolism. Recent studies have highlighted essential roles of m6A readers in
Bing Han, Saisai Wei, Fengying Li, Jun Zhang, Zhongxiang Li, Xiangwei Gao   +5 more
openaire   +2 more sources

Relative Quantification of Residue-Specific m6A RNA Methylation Using m6A-RT-QPCR

2021
Technological advances in high-throughput sequencing in combination with antibody enrichment and/or induced nucleotide-specific chemical modifications have accelerated the mapping of epitranscriptomic modifications. However, site-specific detection and quantification of m6A are still technically challenging.
Ane, Olazagoitia-Garmendia, Ainara, Castellanos-Rubio   +1 more
openaire   +2 more sources

The potential role of m6A RNA methylation in diabetic retinopathy

Experimental Eye Research, 2021
Diabetic retinopathy (DR), a major microvascular complication of diabetes, affects most diabetic individuals and has become the leading cause of vision loss. Metabolic memory associated with diabetes retains the risk of disease occurrence even after the termination of glycemic insult.
Nidhi Kumari, Aditi Karmakar, Md Maqsood Ahamad Khan, Senthil Kumar Ganesan   +3 more
openaire   +2 more sources

Multiple roles of m6A methylation in epithelial–mesenchymal transition

Molecular Biology Reports, 2022
Epithelial-mesenchymal transition (EMT) plays an important role in migration and invasion of cancer cell and the development of tissue fibrosis diseases. N6-methyladenosine (m6A) is the most extensive type of RNA methylation and has aroused extensive interest in recent years.
Xueru Zhao, Xue Li, Xiaohua Li
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Role of m6A RNA Methylation in Ischemic Stroke

Molecular Neurobiology
Ischemic stroke is a prominent contributor to global morbidity and mortality rates. The intricate and diverse mechanisms underlying ischemia-reperfusion injury remain poorly comprehended. RNA methylation, an emerging epigenetic modification, plays a crucial role in regulating numerous biological processes, including immunity, DNA damage response ...
Yayun Xu, Wenqiang Liu, Lijie Ren
openaire   +2 more sources