Results 191 to 200 of about 21,524 (239)

A DRACH Observed/Expected Metric Reveals the Evolutionary Landscape of Epitranscriptomic Regulation Across Bilateria

Annals of the New York Academy of Sciences, Volume 1564, Issue 1, October 2026.
Epitranscriptomic marks are highly variable across life stages and tissues, complicating comparisons between species. Using m6A consensus motifs, we developed a genomic indicator reflecting transcript methylability, the DRACH o/e score, that we used to investigate epitranscriptomic features and associated functions across nine bilaterian species.
Natacha Clairet, Jérémy Le Luyer, Hélène Auger, Maximilian Haeussler, Guillaume Rivière   +4 more
wiley   +1 more source

Integrated analysis of differential m6A methylation and transcriptome profiles in ovaries of young and aged Qira black sheep. [PDF]

BMC Genomics
Pei L, Wang W, Guo P, Qiao A, Duan X, Xu X, Liu C.   +6 more
europepmc   +1 more source

Host–Microbe Mechanisms of Fusobacterium nucleatum in Colorectal Cancer

Molecular Oral Microbiology, Volume 41, Issue 5, Page 258-265, October 2026.
Fusobacterium nucleatum and colorectal cancer. ABSTRACT The oral‐derived pathobiont Fusobacterium nucleatum has increasingly been implicated in colorectal cancer (CRC) progression through its ability to modulate inflammatory, immunological, and molecular pathways. F.
Hadda Lyzandra Austríaco Leite, Fernanda Ferreira Lopes   +1 more
wiley   +1 more source

The role and mechanism of METTL3 in cancer: emerging insights into m6A methylation and therapeutic potential. [PDF]

Eur J Med Res
Yuan F, Zhang W, Xia Y, Zhou X, Gao H.
europepmc   +1 more source

Polystyrene Nanoplastics induced placental toxicology by activating Keap1-mediated ferroptosis via METTL3-dependent m6A methylation. [PDF]

Cell Biol Toxicol
Chen Y, Liu Y, Zhang M, Li S, Yan Y, Yin C.   +5 more
europepmc   +1 more source

PARP1 contributes to intimal hyperplasia by regulating METTL3-mediated m6A methylation of TRAIL. [PDF]

Cell Biol Toxicol
Li S, Pang F, Guo W, Guan W.
europepmc   +1 more source

METTL3 mediates m6A methylation of LCN2 through IGF2BP3 to promote ferroptosis in chronic obstructive pulmonary disease. [PDF]

Hereditas
Chen F, Liu D, Zhu Z, Chen D.
europepmc   +1 more source

FTO promotes the progression of triple-negative breast cancer by regulating the m6A methylation of NFKBIE. [PDF]

Clin Exp Med
Zhang J, Meng X, Zhao B, Wang H, Hu Q, Wang S, Zhou L, Zhang Y, Zhang D.   +8 more
europepmc   +1 more source

EF24 targets METTL3 to reprogram m6A methylation and induce ferroptosis: an epitranscriptomic mechanism with therapeutical potential for glioma. [PDF]

Cell Commun Signal
Yang Y, Jianxu Z, Hao L, Nini Q, Ge L, Jingjie Y, Haozhe P.   +6 more
europepmc   +1 more source

Alkbh5a-mediated m6A methylation promotes seawater adaptation via chromatin remodeling and tonebpa1 activation in anadromous Oncorhynchus mykiss

Tian Y, Yu H, Sun Y, Gundappa MK, Lu Y, Zeng X, Wang B, He J, Zhu H, Li D, Qu Y, Xin C, Yu Y, Meng X, Macqueen D, Gao Q.   +15 more
europepmc   +1 more source