Results 181 to 190 of about 21,524 (239)

METTL14‐Mediated m6A Methylation Preserves Cardiomyocyte Homeostasis and Attenuates Progeria‐Associated Cardiac Remodeling

Aging Cell, Volume 25, Issue 10, October 2026.
Progerin accumulation downregulates the expression of m6A methyltransferases METTL3 and METTL14 in cardiac tissues, impairing m6A modification‐mediated regulation of target genes including Casq2, Ifna and Ifnb, leading to calcium signaling dysregulation and pro‐inflammatory activation in the aged heart.
Shixiao Wang, Jie Zhang, Ying Ao, Dan Rao, Cong Yu, Chenzhong Xu, Ming Wang, Mingying Li, Xin Huang, Jianfei Zhang, Rui Mei, Zhen Zhang, Jie Sun, Juanli Duan, Ying Sun, Zimei Wang, Wen Su, Baohua Liu   +17 more
wiley   +1 more source

Correction: METTL3 accelerates staphylococcal protein A (SpA)-induced osteomyelitis progression by regulating m6A methylation-modified miR-320a. [PDF]

J Orthop Surg Res
Gao D, Shi J, Lu S, Li J, Lv K, Xu Y, Song M.   +6 more
europepmc   +2 more sources

Regulation of m6A methylation in the immune microenvironment in the development of diabetes mellitus. [PDF]

J Transl Med
Deng H, Liu Q, Gong Y, Qiu Y.
europepmc   +1 more source

Tumor‐Derived Exosomal piR‐hsa‐28212 Promotes Lymphatic Metastasis in Breast Cancer

Cancer Science, Volume 117, Issue 10, Page 2733-2751, October 2026.
Breast cancer–derived exosomal piR‐hsa‐28212 promotes lymphangiogenesis and lymph node metastasis by activating VEGFC/VEGFR3 signaling. It stabilizes TBX1 mRNA in lymphatic endothelial cells and METTL3 protein in tumor cells, enhancing VEGFR3 expression and VEGFC secretion.
Yafen Wang, Tianli Zhang, Xue Kong, Yao Tong, Yanru Li, Xiangjun Dong, Chuanxin Wang, Juan Li   +7 more
wiley   +1 more source

METTL14/IGF2BP-mediated m6A methylation of circSLIT2 promotes malignant phenotypes of glioblastoma via the miR-127-5p/SH3GLB1 axis. [PDF]

Am J Cancer Res
Wu L, Jin M, Chen L, Jiang Y, Wang F.
europepmc   +1 more source

N6‐Methyladenosine Demethylase FTO Protects Pancreatic ΒTC6 Cells From Cholesterol‐Triggered Damage by Regulating Nfatc4: Insights From RNA‐Seq Analysis

Chemical Biology &Drug Design, Volume 108, Issue 4, October 2026.
FTO Protects Mouse Pancreatic Beta‐TC‐6 cells From Cholesterol‐Triggered Damage by Repressing Nfatc4. ABSTRACT Excessive cholesterol contributes to pancreatic β‐cell dysfunction and plays a critical role in the pathogenesis of metabolic disorders.
Pingping Hong, Yongjie Li, Jiandong Lin, Lingxiao Wang, Xiaofang Fan, Hongfang Wang, Luping Lou   +6 more
wiley   +1 more source

Polyphenism Through RNA Chemical Modifications

Molecular Ecology, Volume 35, Issue 19, October 2026.
ABSTRACT Polyphenism, the capacity of a single genotype to produce discrete phenotypes in response to environmental cues, has long served as a model for understanding developmental plasticity. While classical studies have highlighted hormonal signalling and transcription‐factor‐driven gene regulatory networks that mediate these environmentally induced ...
Ralf Schneider, Ehsan Pashay Ahi
wiley   +1 more source

The progress of m6A methylation-regulated non-coding RNAs in osteogenic differentiation and osteoporosis. [PDF]

Noncoding RNA Res
Wang Y, Ma B, Qiu J, Yu L, Xiong J, Yu Q, Li X, Liao H, Huang Y, He S.   +9 more
europepmc   +1 more source

Magnesium ions facilitate osteogenic differentiation and intervertebral fusion <i>via</i> m6A methylation of RhoA mRNA. [PDF]

J Orthop Translat
Xu H, Li L, Zhang F, Shao M, Li C, Xue Y, Li D, Lin Z, Gong Z, Wu J, Luo Z, Shi Z, Xia X, Wang H, Ma X, Jiang J, Gu X, Liu Y, Lu X, Lyu F.   +19 more
europepmc   +1 more source