Results 161 to 170 of about 21,524 (239)

Overview on Epstein–Barr Virus–Host Interactions With a Focus on Host Cell Transcriptome Alterations

Cell Biochemistry and Function, Volume 44, Issue 10, October 2026.
ABSTRACT The Epstein–Barr virus (EBV) belongs to the gamma subgroup of human herpesviruses. EBV is particularly lymphotropic regarding its latency, meaning that it preferentially targets lymphocytes as its immunological niche. During the establishment of the complex virus–host relationships, the virus influences the human host cell transcriptome ...
Louise Wallot, Tim Hohmann, Urszula Hohmann, Faramarz Dehghani, Olaf Grisk, Simon Jasinski‐Bergner   +5 more
wiley   +1 more source

METTL3 Increases Temozolomide Resistance in MGMT‐Negative Glioblastoma by Enhancing CBX5 mRNA Stability in an m6A‐IGF2BP2‐Dependent Manner

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
METTL3‐dependent m6A modification and IGF2BP2‐associated CBX5 mRNA stabilization help maintain CBX5 expression in MGMT‐negative glioblastoma. During temozolomide (TMZ) treatment, CBX5 contributes to ATM–RAD51‐associated signaling, limits persistent DNA damage and apoptosis, and thereby supports cell survival and TMZ resistance.
Hui Deng, Ruoyu Chen, Daohong Qu, Cifu Qu, Jia Shi   +4 more
wiley   +1 more source

N6-methyladenosine (m6A) methylation in adipose tissue: role, regulation, and therapeutic potential. [PDF]

Cell Mol Life Sci
Liu Q, Peng WQ, Guo L.
europepmc   +1 more source

Lactate metabolism and protein lactylation in programmed cell death: From novel mechanism to therapeutic strategies in human diseases

Clinical and Translational Medicine, Volume 16, Issue 10, October 2026.
This review highlights protein lactylation as a metabolic‐epigenetic regulator linking lactate reprogramming to programmed cell death. By modulating histone and non‐histone targets, lactylation reshapes cell fate decisions and represents a promising biomarker and therapeutic target in human diseases.
Yue Chen, Xiwen Wang, Xiuping Wang, Na Lin, Wenjie Wang, Ruiqi Fu, Yutong Wu, Yi Liu, Hengwei Liu   +8 more
wiley   +1 more source

Mechanism of ORC1 Regulating Cancer Stemness and Cisplatin Resistance in Non‐Small Cell Lung Cancer

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 10, October 2026.
Elevated ORC1 expression in non‐small cell lung cancer (NSCLC) simultaneously activates cancer stemness and epithelial‐mesenchymal transition (EMT). Upregulation of stemness‐associated factors (NANOG, LGR5, CD133+CD44+ CSCs) and EMT transcription factors (SNAI1, SNAI2, TWIST1) synergistically induce MDR1 overexpression. Increased MDR1 ultimately drives
Jianhui Sheng, Yingjian Song
wiley   +1 more source

Electroacupuncture Ameliorates Premature Ovarian Insufficiency by Inhibiting METTL3-Mediated m6A Methylation of Beclin 1 mRNA in Granulosa Cells. [PDF]

Food Sci Nutr
Ling L, He S, Zhao X, Sheng Y, Hong M, Yuan L, Liu P, Ke B, Li B, Zhang B.   +9 more
europepmc   +1 more source

Extracellular Vesicles: Classification, Biological Functions, Diseases, and Therapeutic Opportunities

MedComm, Volume 7, Issue 10, October 2026.
• EV content maintains cellular homeostasis and is involved in several disease onset and progression. • miRNA export in EVs depends on: RNA‐binding proteins recognizing motif sequences and on epitranscriptomic modifications. • The disclosure of delivery mechanisms is crucial for developing personalized EV‐based therapeutic tools. ABSTRACT Extracellular
Sabrina Garbo, Francesco Marocco, Clemens Zwergel, Marco Tripodi, Cecilia Battistelli   +4 more
wiley   +1 more source

WTAP-mediated m6A methylation of SOX2 affects lung adenocarcinoma malignancy via Wnt/β-catenin pathway. [PDF]

Front Genet
Li N, Zeng X, Xie H, Fan Y, You S.
europepmc   +1 more source

Maturation‐Dependent Constraints in the Ability of Human Monocytes to Initiate Trained Immunity

MedComm, Volume 7, Issue 10, October 2026.
In premature infants, innate immune memory may serve as an important compensatory mechanism for the underdeveloped adaptive immune system. However, monocytes derived from prematurely born individuals display abnormal metabolic and insufficient transcriptomic responses to β‐glucan‐induced training.
Michael Eigenschink, Elsa Davogg, Manuel Pristner, David Seki, Marcus Arzmüller, Herbert Kiss, Alex Farr, Angelika Berger, David Berry, Benedikt Warth, Lukas Wisgrill   +10 more
wiley   +1 more source

The Intersection of m6A Methylation and Immune Response in PCOS: A Bioinformatics Perspective. [PDF]

Immun Inflamm Dis
Xu W, Shi L, Lu A, Cui L, Qian H, Wang J, Tang M, Zhu L, Wang L.   +8 more
europepmc   +1 more source