Results 61 to 70 of about 26,139 (253)

The how and why of lncRNA function: An innate immune perspective. [PDF]

, 2020
Next-generation sequencing has provided a more complete picture of the composition of the human transcriptome indicating that much of the "blueprint" is a vastness of poorly understood non-protein-coding transcripts.
Carpenter, Susan, Covarrubias, Sergio, Robinson, Elektra K   +2 more
core  

m6A methylation: a process reshaping the tumour immune microenvironment and regulating immune evasion

Molecular Cancer, 2023
N6-methyladenosine (m6A) methylation is the most universal internal modification in eukaryotic mRNA. With elaborate functions executed by m6A writers, erasers, and readers, m6A modulation is involved in myriad physiological and pathological processes ...
Xiaoxue Cao, Qishun Geng, Danping Fan, Qiong Wang, Xing Wang, Mengxiao Zhang, Lu Zhao, Yi Jiao, Tingting Deng, Honglin Liu, Jing Zhou, Liqun Jia, Cheng Xiao   +12 more
doaj   +1 more source

Comparison of RNA m6A and DNA methylation profiles between mouse female germline stem cells and STO cells

Molecular Therapy: Nucleic Acids, 2021
N6-methyladenosine (m6A) methylation modification is the most prevalent and abundant internal modification of eukaryotic mRNAs. Increasing evidence has shown that mRNA m6A plays important roles in the development of stem cells.
Xinyan Zhao, Geng G. Tian, Qian Fang, Xiuying Pei, Zhaoxia Wang, Ji Wu   +5 more
doaj   +1 more source

Abnormality of m6A mRNA Methylation Is Involved in Alzheimer’s Disease

Frontiers in Neuroscience, 2020
Alzheimer’s disease (AD), the most common form of dementia, is highly prevalent in older adults. The main clinical feature is the progressive decline of memory function, which eventually leads to the decline of cognitive function.
Min Han, Zhen Liu, Yingying Xu, Xiangtian Liu, Dewei Wang, Fan Li, Yun Wang, Jianzhong Bi   +7 more
doaj   +1 more source

m6A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade [PDF]

, 2019
Melanoma is one of the most deadly and therapy-resistant cancers. Here we show that N6-methyladenosine (m6A) mRNA demethylation by fat mass and obesity-associated protein (FTO) increases melanoma growth and decreases response to anti-PD-1 blockade ...
Aplin, Andrew E., Cui, Yan-Hong, Deng, Yu, He, Chuan, He, Yu-Ying, Hwang, Seungmin, Lu, Zhike, Park, Gayoung, Shah, Palak, Wei, Jiangbo, Yang, Seungwon   +10 more
core   +1 more source

m^6A RNA methylation promotes XIST-mediated transcriptional repression [PDF]

, 2016
The long non-coding RNA X-inactive specific transcript (XIST) mediates the transcriptional silencing of genes on the X chromosome. Here we show that, in human cells, XIST is highly methylated with at least 78 N^6-methyladenosine (m^6A) residues—a ...
A Minajigi, A Wutz, A Wutz, AJ Link, AM Hartmann, Amy Chow, B Linder, B Moindrot, Brian F. Pickering, C Chu, CA McHugh, Chun-Kan Chen, CM Wei, Constanza Jackson, CR Alarcón, D Dominissini, Deepak P. Patil, F Ramírez, FL Wilkinson, G Jia, G Singh, GD Penny, H Uranishi, I Huppertz, J Kochan, J König, J Schindelin, J Zhao, JA Bokar, JM Engreitz, K Horiuchi, K Morohashi, K Plath, KD Meyer, KD Meyer, KD Meyer, L Berglund, L Bylund, Mitchell Guttman, MJ Cowley, N Liu, P Shannon, Q Cao, S Geula, S Heinz, S Niranjanakumari, S Schwartz, S Zhong, Samie R. Jaffrey, SC Kwon, SD Agarwala, SM Weyn-Vanhentenryck, W Ma, W Xiao, X Wang, X Wang, XL Ping, Y Hasegawa, YC Lin   +58 more
core   +2 more sources

Tendon Organoids Enable Functional Tendon Rejuvenation Through ALKBH5‐Dependent RNA Demethylation

Advanced Science, EarlyView.
FT organoids reverse the aged phenotype of tendon cells, reinstating a fetal‐like state. This breakthrough establishes a potent cell source for tendon tissue engineering, effectively advancing regenerative medicine. ABSTRACT Adult tendon injuries pose a major clinical challenge due to limited self‐repair capacity, resulting in suboptimal regeneration ...
Tian Qin, Aini Pan, Zhuoning Miao, Yanyan Zhao, Xianan Mo, Heng Sun, Chunmei Fan, Junyu Guo, Bingbing Wu, Weiliang Shen, Qiangqiang Zheng, Jun Lu, Xi Jiang, Zi Yin, Xiao Chen   +14 more
wiley   +1 more source

m6A RNA Methylation Regulators Impact Prognosis and Tumor Microenvironment in Renal Papillary Cell Carcinoma

Frontiers in Oncology, 2021
Accumulating evidence has proven that N6-methyladenosine (m6A) RNA methylation plays an essential role in tumorigenesis. However, the significance of m6A RNA methylation modulators in the malignant progression of papillary renal cell carcinoma (PRCC) and
Lianze Chen, Lianze Chen, Baohui Hu, Baohui Hu, Xinyue Song, Xinyue Song, Lin Wang, Lin Wang, Mingyi Ju, Mingyi Ju, Zinan Li, Zinan Li, Chenyi Zhou, Chenyi Zhou, Ming Zhang, Ming Zhang, Qian Wei, Qian Wei, Qiutong Guan, Qiutong Guan, Longyang Jiang, Longyang Jiang, Ting Chen, Ting Chen, Minjie Wei, Minjie Wei, Minjie Wei, Lin Zhao, Lin Zhao   +28 more
doaj   +1 more source

Genome-wide Maps of Nuclear Lamina Interactions in Single Human Cells [PDF]

, 2017
Mammalian interphase chromosomes interact with the nuclear lamina (NL) through hundreds of large lamina-associated domains (LADs). We report a method to map NL contacts genome-wide in single human cells.
Amendola, Mario, Bienko, Magda, Dekker, Job, Dey, Siddharth S., de Graaf, Carolyn A., de Vries, Sandra S., Fudenberg, Geoffrey, Imakaev, Maksim Viktorovich, Jalink, Kees, Kind, Jop, Lajoie, Bryan, Mirny, Leonid A, Nahidiazar, Leila, Pagie, Ludo, van Oudenaarden, Alexander, van Steensel, Bas, Zhan, Ye   +16 more
core   +1 more source

The Critical Role of RNA m6A Methylation in Cancer [PDF]

Cancer Research, 2019
Abstract Since the identification of the first RNA demethylase and the establishment of methylated RNA immunoprecipitation-sequencing methodology 6 to 7 years ago, RNA methylation has emerged as a widespread phenomenon and a critical regulator of transcript expression. This new layer of regulation is termed “epitranscriptomics.” The most
Lan, Q, Liu, PY, Haase, J, Bell, JL, Huttelmaier, S, Liu, T   +5 more
openaire   +3 more sources