Results 41 to 50 of about 21,524 (239)
Prognostic and therapeutic implication of m6A methylation in Crohn disease
Medicine, 2022 Background: N6-methyladenosine (m6A) methylation has been reported to participate in inflammatory bowel disease (including Crohn disease [CD]). However, the prognostic and therapeutic implication of m6A methylation modification in CD is still unclear. Methods: Genomic information of
Yujin He +5 more
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Frontiers in Plant Science, 2021 The remodeling of transcriptome, epigenome, proteome, and metabolome in hybrids plays an important role in heterosis. N(6)-methyladenosine (m6A) methylation is the most abundant type of post-transcriptional modification for mRNAs, but the pattern of ...
Zhihui Xu +14 more
doaj +1 more source
Correlations of m6A methylation-related mRNAs with thyroid cancer. [PDF]
Sci RepN6-methyladenosine (m6A) RNA methylation plays a crucial role in tumorigenesis. However, the specific role of m6A modifications in the malignant progression of papillary thyroid carcinoma (PTC) without autoimmune thyroid disease (AITD) remains unclear.
Jiang Z, Luo S, Lin Y, Zhang H, Yi R.
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m6A RNA methylation regulates the fate of endogenous retroviruses
Nature, 2021 Endogenous retroviruses (ERVs) are abundant and heterogenous groups of integrated retroviral sequences that affect genome regulation and cell physiology throughout their RNA-centred life cycle1. Failure to repress ERVs is associated with cancer, infertility, senescence and neurodegenerative diseases2,3.
Chelmicki, Tomasz +9 more
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Global profiling of N6‐methyladenosine methylation in maize callus induction
The Plant Genome, 2020 Callus induction is a dedifferentiation process that accompanies a cell fate transition, and epigenetic regulation plays a crucial role in the process.
Xuemei Du +11 more
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m6A Methylation Modification: Perspectives on the Early Reproduction of Females. [PDF]
BiomoleculesThis review examines the regulatory role of m6A methylation modification in embryo implantation, focusing specifically on its impact on uterine receptivity and decidualization. It offers a comprehensive examination of the essential theoretical research on m6A methylation, clarifying its molecular mechanisms and roles in uterine receptivity and ...
Yang Y, Zheng Z.
europepmc +3 more sources
Frontiers in GeneticsOsteosarcoma (OS), an aggressive bone tumor, is a substantial threat to the quality of life and survival of affected individuals. Despite recent improvements in OS therapies, the considerable variability and chemotherapy resistance of this cancer ...
Huaqiang Zhou +7 more
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Region-specific RNA m6A methylation represents a new layer of control in the gene regulatory network in the mouse brain [PDF]
Open Biology, 2017 N6-methyladenosine (m6A) is the most abundant epitranscriptomic mark found on mRNA and has important roles in various physiological processes. Despite the relatively high m6A levels in the brain, its potential functions in the brain remain largely ...
Mengqi Chang +10 more
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Abnormality of m6A mRNA Methylation Is Involved in Alzheimer’s Disease
Frontiers in Neuroscience, 2020 Alzheimer’s disease (AD), the most common form of dementia, is highly prevalent in older adults. The main clinical feature is the progressive decline of memory function, which eventually leads to the decline of cognitive function.
Min Han +7 more
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Molecular Cancer, 2023 N6-methyladenosine (m6A) methylation is the most universal internal modification in eukaryotic mRNA. With elaborate functions executed by m6A writers, erasers, and readers, m6A modulation is involved in myriad physiological and pathological processes ...
Xiaoxue Cao +12 more
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