Results 61 to 70 of about 21,524 (239)

RNA m6A methylation regulators in liver cancer

Cancer Cell International
AbstractLiver cancer is one of the most common cancers in the world and a primary cause of cancer-related death. In recent years, despite the great development of diagnostic methods and targeted therapies for liver cancer, the incidence and mortality of liver cancer are still on the rise.
Qiaoping Xu, Ning Ren, Lanqi Ren, Yibei Yang, Junjie Pan, Hongkai Shang   +5 more
openaire   +3 more sources

A Role for m6A RNA Methylation in Heart Failure Development? [PDF]

European Journal of Heart Failure, 2019
This article refers to ‘Changes in m6A RNA methylation contribute to heart failure progression by modulating translation’ by T. Berulava et al., published in this issue on pages 54–66.
Yvan, Devaux, Anne Yaël, Nossent
openaire   +3 more sources

mRNA N6-methyladenosine methylation of postnatal liver development in pig.

PLoS ONE, 2017
N6-methyladenosine (m6A) is a ubiquitous reversible epigenetic RNA modification that plays an important role in the regulation of post-transcriptional protein coding gene expression.
Shen He, Hong Wang, Rui Liu, Mengnan He, Tiandong Che, Long Jin, Lamei Deng, Shilin Tian, Yan Li, Hongfeng Lu, Xuewei Li, Zhi Jiang, Diyan Li, Mingzhou Li   +13 more
doaj   +1 more source

Multiple m6A RNA methylation modulators promote the malignant progression of hepatocellular carcinoma and affect its clinical prognosis

BMC Cancer, 2020
Background Hepatocellular carcinoma (HCC) is the second most common cause of cancer-related death in the world. N6-methyladenosine (m6A) RNA methylation is dynamically regulated by m6A RNA methylation modulators (“writer,” “eraser,” and “reader” proteins)
Nanfang Qu, Sanyu Qin, Xuemei Zhang, Xiaotong Bo, Zhengchun Liu, Chao Tan, Guiqiong Wen, Haixing Jiang   +7 more
doaj   +1 more source

WTAP affects intracranial aneurysm progression by regulating m6A methylation modification

Open Medicine, 2023
Intracranial aneurysm (IA) is a type of cerebrovascular disease that mainly occurs in the circle of Willis. Abnormalities in RNA methylation at the N6-methyladenosine (m6A) site have been associated with numerous types of human diseases.
Yuan Xuesong, Bao Qing, Lu Bin, Xiang Chong, Hou Xiaoshan, Wei Wenfeng   +5 more
doaj   +1 more source

Exploration of the Role of m6 A RNA Methylation Regulators in Malignant Progression and Clinical Prognosis of Ovarian Cancer

Frontiers in Genetics, 2021
Ovarian cancer is the most deadly gynecologic malignancy worldwide and it is warranted to dissect the critical gene regulatory network in ovarian cancer. N6-methyladenosine (m6A) RNA methylation, as the most prevalent RNA modification, is orchestrated by
Qinglv Wei, Dan Yang, Xiaoyi Liu, Hongyan Zhao, Yu Yang, Jing Xu, Tao Liu, Ping Yi   +7 more
doaj   +1 more source

Targeting the NR1D1–IGF2BP2–V‐ATPase Axis With Hybrid Nanovesicles Restores Macrophage Rhythms to Reverse Sepsis‐Induced Immunosuppression

Advanced Science, EarlyView.
Sepsis disrupts immune‐cell rhythms and weakens bacterial clearance. Biomimetic nanovesicles combining erythrocyte and inflammation‐activated macrophage membranes deliver siNR1D1 to dysfunctional macrophages, restoring the NR1D1–IGF2BP2–V‐ATPase pathway, circadian regulation, phagolysosomal acidification, and antimicrobial defense.
Lang Chen, Wenyi Lin, Lang Jiang, Xuehui Gao, Chenyan Yu, Jili Han, Zhenping Liu, Xuefeng Li, Mei He, Chang Li, Qilan Li, Chaoying Song, Jiqian Xu, You Shang   +13 more
wiley   +1 more source

m6A methylation: a new frontier in epilepsy research and therapeutics. [PDF]

EXCLI J
Epilepsy is a highly complex and global neurological disorder, for which available treatments only inadequately control the disease in many patients. Recent advances in molecular research have identified N6-methyladenosine (m6A) RNA modifications as key regulators of neuronal processes that underpin the pathophysiology of epilepsy.
Maqbool M, Khan Y, Arab MM, Alshammari SO, Hussain MS, Almufarriji FM.   +5 more
europepmc   +3 more sources

ACSL4‐Dependent Lysosomal Lipid Peroxidation Links WTAP‐Mediated m6A Modification to Intervertebral Disc Degeneration

Advanced Science, EarlyView.
IL‐1β upregulates the protein level of WTAP, which promotes the m6A modification of ACSL4 mRNA in an IGF2BP2‐dependent manner, thereby enhancing its stability. The increased ACSL4 drives lipid peroxidation, leading to lysosomal membrane permeabilization (LMP) and impaired mitophagy, which collectively accelerate intervertebral disc degeneration (IVDD).
Shu Jia, Xu Gao, Laimin Zhu, Haixia Song, Jing Wu, Shang Chen, Sheng Gao, Lu Zhang, Chunyang Meng   +8 more
wiley   +1 more source

IL-37 Confers Anti-Tumor Activity by Regulation of m6A Methylation

Frontiers in Oncology, 2021
N6-methyladenosine (m6A) is a common transcriptomic modification in cancer. Recently, it has been found to be involved in the regulation of non-small cell lung cancer (NSCLC) formation and metastasis.
Xiaofeng Mu, Xiaofeng Mu, Qi Zhao, Wen Chen, Yuxiang Zhao, Yuxiang Zhao, Qing Yan, Rui Peng, Jie Zhu, Chunrui Yang, Ketao Lan, Xiaosong Gu, Ye Wang   +12 more
doaj   +1 more source