Results 21 to 30 of about 21,524 (239)
Ecotoxicology and Environmental Safety, 2022 Silicosis is one of the most severe interstitial lung fibrosis diseases worldwide, caused by crystalline silica exposure. While the mechanisms and pathogenesis underlying silicosis remained unknown.
Yingdie Zhang +8 more
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Frontiers in Pharmacology, 2022 N6-methyladenosine (m6A) RNA methylation has been considered the most prevalent, abundant, and conserved internal transcriptional modification throughout the eukaryotic mRNAs.
Zhaolin Chen +7 more
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The role of m6A methylation in therapy resistance in cancer
Molecular Cancer, 2023 AbstractCancer therapy resistance is the main cause of cancer treatment failure. The mechanism of therapy resistance is a hot topic in epigenetics. As one of the most common RNA modifications, N6-methyladenosine (m6A) is involved in various processes of RNA metabolism, such as stability, splicing, transcription, translation, and degradation.
Hengzhao Zhuang +7 more
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The m6A epitranscriptome on neural development and degeneration
Journal of Biomedical Science, 2021 N 6-methyladenosine (m6A) is the most prevalent, conserved, and abundant RNA modification of the mRNAs of most eukaryotes, including mammals. Similar to epigenetic DNA modifications, m6A has been proposed to function as a critical regulator for gene ...
Ya-Ping Yen, Jun-An Chen
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The role of m6A RNA methylation in cancer
Biomedicine & Pharmacotherapy, 2019 N6-methyladenosine (m6A), the most abundant internal modification of RNA in eukaryotic cells, has gained increasing attention in recent years. The m6A modification affects multiple aspects of RNA metabolism, ranging from RNA processing, nuclear export, RNA translation to decay.
Ting, Sun, Ruiyan, Wu, Liang, Ming
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Frontiers in Cell and Developmental Biology, 2023 Background:Helicobacter pylori (H.pylori) infection is an important factor in the occurrence of human gastric diseases, but its pathogenic mechanism is not clear.
Huan Li +11 more
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The Critical Role of RNA m6A Methylation in Cancer [PDF]
Cancer Research, 2019 Abstract Since the identification of the first RNA demethylase and the establishment of methylated RNA immunoprecipitation-sequencing methodology 6 to 7 years ago, RNA methylation has emerged as a widespread phenomenon and a critical regulator of transcript expression. This new layer of regulation is termed “epitranscriptomics.” The most
Lan, Q +5 more
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Characterization of m6A methylation modifications in gastric cancer
Aging, 2023 Widely recognized as an essential epitranscriptomic modification, RNA N6-methyladenosine (m6A) is involved in both physiological and pathological processes. Here, we want to investigate m6A modification's potential roles in gastric cancer. Gastric cancer samples were selected from TCGA-STAD and GEO (GSE84426, GSE84433) datasets.
Yin, Wei +5 more
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Research Progress on Long Noncoding RNAs and N6-Methyladenosine in Hepatocellular Carcinoma
Frontiers in Oncology, 2022 N6-methyladenosine (m6A) is an epigenetic modification that widely exists in long noncoding RNAs (lncRNAs) and is involved in the regulation of oncogenes or tumor suppressor genes that form complex enzymes to affect the occurrence of tumors. The abnormal
Wenjie Zhang +10 more
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Genome Biology, 2019 Background Methylation of nucleotides, notably in the forms of 5-methylcytosine (5mC) in DNA and N6-methyladenosine (m6A) in mRNA, carries important information for gene regulation.
Leilei Zhou, Shiping Tian, Guozheng Qin
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