Results 11 to 20 of about 21,524 (239)
Editorial: m6A methylation and cancer immunity. [PDF]
Front ImmunolChen Q, Yuan H, Wu PF.
europepmc +4 more sources
The role of m6A RNA methylation in cancer metabolism [PDF]
Molecular Cancer, 2022 AbstractMetabolic reprogramming is one of the main characteristics of malignant tumors, which is due to the flexible changes of cell metabolism that can meet the needs of cell growth and maintain the homeostasis of tissue environments. Cancer cells can obtain metabolic adaptation through a variety of endogenous and exogenous signaling pathways, which ...
Yuanyuan An, Hua Duan
openaire +3 more sources
RNA m6A methylation regulators in ovarian cancer [PDF]
Cancer Cell International, 2021 AbstractN6-methyladenosine (m6A) is the most abundant RNA modification of mammalian mRNAs and plays a vital role in many diseases, especially tumours. In recent years, m6A has become the topic of intense discussion in epigenetics. M6A modification is dynamically regulated by methyltransferases, demethylases and RNA-binding proteins. Ovarian cancer (OC)
Jialu Guo +3 more
openaire +3 more sources
RNA m6A methylation across the transcriptome
Molecular Cell, 2023 Since the early days of foundational studies of nucleic acids, many chemical moieties have been discovered to decorate RNA and DNA in diverse organisms. In mammalian cells, one of these chemical modifications, N6-methyl adenosine (m6A), is unique in a way that it is highly abundant not only on RNA polymerase II (RNAPII) transcribed, protein-coding ...
Erdem, Sendinc, Yang, Shi
openaire +4 more sources
The role of m6A RNA methylation regulator in meningioma
Aging, 2023 Meningiomas are common intracranial tumors, and the effect of surgical resection is often unsatisfactory. N6-Methyladenosine (m6A)-related regulator expression levels are related to cancer occurrence and development. This study aimed to investigate the roles of m6A RNA methylation regulators in meningiomas, as these are currently unclear.
Yang, Yu, Luo, Liqin, Zhou, Zhiwu
openaire +2 more sources
m6a RNA Methylation: The Implications for Health and Disease [PDF]
Journal of Cancer Science and Clinical Oncology, 2014 The recent resurgence of interest in m6a has been spurred by some intriguing findings detailing the effects and dynamics of this epigenetic modification. The m6a modification is a highly reactive and fluid modification which can respond rapidly to a broad variety of stimuli, and translate these signals into cellular activity.
Mcguinness, D.H., McGuinness, D.
openaire +2 more sources
Association between ankylosing spondylitis and m6A methylation
Journal of Orthopaedic Surgery and Research, 2023 Abstract Background N6-methyl adenosine (m6A) is the most common reversible mRNA modification in eukaryotes implicated in key roles in various biological processes. The purpose of our analysis was to examine the association of ankylosing spondylitis (AS) with m6A methylation. Method
Zhiwei Luan, Yansong Wang
openaire +3 more sources
Ginsenoside Rh2 reduces m6A RNA methylation in cancer via the KIF26B-SRF positive feedback loop
Journal of Ginseng Research, 2021 Background: The underlying mechanisms of the potential tumor-suppressive effects of ginsenoside Rh2 are complex. N6-methyladenosine (m6A) RNA methylation is usually dysregulated in cancer.
Chunmei Hu +5 more
doaj +1 more source
Analysis approaches for the identification and prediction of N6-methyladenosine sites
Epigenetics, 2023 The global dynamics in a variety of biological processes can be revealed by mapping transcriptional m6A sites, in particular full-transcriptome m6A.
Yuwei Yang +7 more
doaj +1 more source
The Biogenesis and Precise Control of RNA m6A Methylation [PDF]
Trends in Genetics, 2020 N6-Methyladenosine (m6A) is the most prevalent internal RNA modification in mRNA, and has been found to be highly conserved and hard-coded in mammals and other eukaryotic species. The importance of m6A for gene expression regulation and cell fate decisions has been well acknowledged in the past few years.
Huilin, Huang +2 more
openaire +2 more sources