Results 81 to 90 of about 26,139 (253)

RNA m6A methylation regulators in liver cancer

Cancer Cell International
AbstractLiver cancer is one of the most common cancers in the world and a primary cause of cancer-related death. In recent years, despite the great development of diagnostic methods and targeted therapies for liver cancer, the incidence and mortality of liver cancer are still on the rise.
Qiaoping Xu, Ning Ren, Lanqi Ren, Yibei Yang, Junjie Pan, Hongkai Shang   +5 more
openaire   +3 more sources

m6A RNA methylation orchestrates transcriptional dormancy during paused pluripotency

Nature Cell Biology, 2023
Embryos across metazoan lineages can enter reversible states of developmental pausing, or diapause, in response to adverse environmental conditions. The molecular mechanisms that underlie this remarkable dormant state remain largely unknown. Here we show that N6-methyladenosine (m6A) RNA methylation by Mettl3 is required for developmental pausing in ...
Evelyne Collignon, Brandon Cho, Giacomo Furlan, Julie Fothergill-Robinson, Sylvia-Bryn Martin, Sarah A. McClymont, Robert L. Ross, Patrick A. Limbach, Miguel Ramalho-Santos   +8 more
openaire   +2 more sources

BGN/MDK Axis in the Melanoma Tumor Microenvironment Strengthens Tumor Malignancy by Modulating Cancer Cells and Cancer‐Associated Fibroblasts Crosstalk

Advanced Science, EarlyView.
This study reveals that m6A regulators cooperatively upregulate BGN in melanoma, promoting malignancy. Within the tumor microenvironment, CAFs show highest BGN expression. The BGN/MDK axis mediates cancer‐stroma crosstalk, driving normal fibroblast (NF) activation and enhancing the pro‐tumor effect of CAFs, highlighting a promising therapeutic target ...
Hao‐ze Shi, Ming‐yang Wu, Jin‐quan Liu, Cuicui Tian, Li Ma, Xue‐mei Zhou, Ze‐Hao Sun, Zhi‐yong Xu, Run‐dong Zhang, Shan‐yuan Ye, Li‐ming Huang, Yan Wang, Jing‐shu Xiong, Wen‐bo Bu, Xian‐feng Cheng, Jian‐fang Sun, Hao Chen   +16 more
wiley   +1 more source

mRNA N6-methyladenosine methylation of postnatal liver development in pig.

PLoS ONE, 2017
N6-methyladenosine (m6A) is a ubiquitous reversible epigenetic RNA modification that plays an important role in the regulation of post-transcriptional protein coding gene expression.
Shen He, Hong Wang, Rui Liu, Mengnan He, Tiandong Che, Long Jin, Lamei Deng, Shilin Tian, Yan Li, Hongfeng Lu, Xuewei Li, Zhi Jiang, Diyan Li, Mingzhou Li   +13 more
doaj   +1 more source

WTAP affects intracranial aneurysm progression by regulating m6A methylation modification

Open Medicine, 2023
Intracranial aneurysm (IA) is a type of cerebrovascular disease that mainly occurs in the circle of Willis. Abnormalities in RNA methylation at the N6-methyladenosine (m6A) site have been associated with numerous types of human diseases.
Yuan Xuesong, Bao Qing, Lu Bin, Xiang Chong, Hou Xiaoshan, Wei Wenfeng   +5 more
doaj   +1 more source

Structure and regulation of ZCCHC4 in m6A-methylation of 28S rRNA. [PDF]

, 2019
N6-methyladenosine (m6A) modification provides an important epitranscriptomic mechanism that critically regulates RNA metabolism and function. However, how m6A writers attain substrate specificities remains unclear. We report the 3.1 Å-resolution crystal
Gao, Linfeng, Huang, Mengjiang, Li, Dongxu, Lu, Jiuwei, Ren, Wendan, Song, Jikui, Wang, Gang Greg   +6 more
core  

An integrated whole genome analysis of Mycobacterium tuberculosis reveals insights into relationship between its genome, transcriptome and methylome. [PDF]

, 2019
Human tuberculosis disease (TB), caused by Mycobacterium tuberculosis (Mtb), is a complex disease, with a spectrum of outcomes. Genomic, transcriptomic and methylation studies have revealed differences between Mtb lineages, likely to impact on ...
A Fallow, A Hénaut, A Roetzer, A Stamatakis, AC Crampin, AC Nica, AD Tischler, AM Bolger, CU Koser, DW Huang, ED Benavente, F Coll, G Li, G Rose, H Li, I Parwati, J Casadesús, J Phelan, J Quigley, JE Galagan, K Winglee, L Zhu, M Coscolla, M Merker, MB Reed, MD Robinson, MM Suzuki, P Domenech, P Kumar, Q Gao, R Balbontín, R Brosch, R Colangeli, R Hershberg, R Pandey, R Sinha, RJC Balhana, S Adhikari, S Anders, S Homolka, S Turkarslan, SK Ahn, SS Shell, T Cortes, T Oshima   +44 more
core   +3 more sources

Antagonistic Ubiquitin Switching by USP7 and RNF40 Orchestrates KDM6A Homeostasis to License Coronavirus Susceptibility

Advanced Science, EarlyView.
We identify an antagonistic ubiquitin circuit that controls cellular permissiveness to multiple coronaviruses. The deubiquitinase USP7 stabilizes the epigenetic regulator KDM6A to upregulate viral receptors, while the E3 ligase RNF40 degrades KDM6A by catalyzing K6/K11‐ubiquitin chains of KDM6A for autophagic degradation.
Meng‐Zhuo Huang, Zhong‐Yuan Yang, Shi Wang, Yan Ge, Lan Lin, Mia Madel Alfajaro, Renata B. Filler, Wan‐Yao Song, Ming‐Zhu Kong, Jin Wei   +9 more
wiley   +1 more source

Multiple m6A RNA methylation modulators promote the malignant progression of hepatocellular carcinoma and affect its clinical prognosis

BMC Cancer, 2020
Background Hepatocellular carcinoma (HCC) is the second most common cause of cancer-related death in the world. N6-methyladenosine (m6A) RNA methylation is dynamically regulated by m6A RNA methylation modulators (“writer,” “eraser,” and “reader” proteins)
Nanfang Qu, Sanyu Qin, Xuemei Zhang, Xiaotong Bo, Zhengchun Liu, Chao Tan, Guiqiong Wen, Haixing Jiang   +7 more
doaj   +1 more source

N6-Methyladenosine-Regulated mRNAs: Potential Prognostic Biomarkers for Patients With Lung Adenocarcinoma

Frontiers in Cell and Developmental Biology, 2021
Aberrant regulation of m6A mRNA modification can lead to changes in gene expression, thus contributing to tumorigenesis in several types of solid tumors.
Junjun Sun, Yili Ping, Jingjuan Huang, Bingjie Zeng, Ping Ji, Dong Li   +5 more
doaj   +1 more source