Results 141 to 150 of about 1,875,792 (320)

Identification of methylated deoxyadenosines in vertebrates reveals diversity in DNA modifications. [PDF]

, 2015
Methylation of cytosine deoxynucleotides generates 5-methylcytosine (m(5)dC), a well-established epigenetic mark. However, in higher eukaryotes much less is known about modifications affecting other deoxynucleotides. Here, we report the detection of N(6)-
A Morgulis, Ana S H Costa, BA Braaten, BF Vanyushin, C Zang, Charles R Bradshaw, Christian Frezza, D Dominissini, D Roberts, E Ford, EL Greer, EM Reyes, EM Zdobnov, F Laengle-Rouault, G Bertani, G Zhang, GE Geier, George E Allen, H Kobayashi, H Li, J Boyes, JB Bowes, John B Gurdon, KS Pollard, L Micallef, M Lawrence, M Lu, Magdalena J Koziol, MG Marinus, MS May, PA Jones, PD Lawley, PD Thomas, PH Kay, RD Hotchkiss, S Ito, SE Luria, T Pfaffeneder, TL Bailey, TW Munns, U Gunthert, WA Cantara, WJ Kent, Y Fu, Y Gruenbaum   +44 more
core   +2 more sources

Tumor‐educated platelets in cancer diagnostics and prognostics: A critical appraisal and roadmap for clinical translation

International Journal of Cancer, EarlyView.
Abstract Tumor‐educated platelets (TEPs) are emerging as a compelling frontier in liquid biopsy, functioning as dynamic, systemic sensors that sequester and process tumor‐derived biomolecules. This interaction imprints an integrated molecular signature of malignancy—spanning the transcriptome, proteome, lipidome, and crucially, the captured genome ...
Whi‐An Kwon, Min‐Kyung Lee, Eunyong Ahn, Heeyeon Kim, Yong Sang Song, Taejin Ahn   +5 more
wiley   +1 more source

N6-methyladenosine (m6A) modification in hepatocellular carcinoma

Biomedicine & Pharmacotherapy
Hepatocellular carcinoma (HCC) is one of the deadliest cancers of human, the tumor-related death of which ranks third among the common malignances. N6-methyladenosine (m6A) methylation, the most abundant internal modification of RNA in mammals, participates in the metabolism of mRNA and interrelates with ncRNAs. In this paper, we overviewed the complex
Hehua Ma, Yuxin Hong, Zhenzhen Xu, Zuyi Weng, Yuanxun Yang, Dandan Jin, Zhiyou Chen, Jing Yue, Xuan Zhou, Zhi Xu, Fei Fei, Juan Li, Wei Song   +12 more
openaire   +2 more sources

Epigenetic Regulation in the Pathogenesis of Renal Inflammation: Insights and Therapeutic Potentials

iNew Medicine, EarlyView.
ABSTRACT Renal inflammation is a common pathological process in various kidney diseases, often initiated by factors such as toxins, ischemia, or autoimmune reactions. This inflammatory response can result in structural damage and a rapid decline in renal function.
Yu‐Hang Dong, Xiao‐Yu Shen, Han‐Cheng Jin, Xiang‐Yu Li, Hao He, Xiao‐Ming Meng   +5 more
wiley   +1 more source

The AlkB Family of Fe(II)/α-Ketoglutarate-dependent Dioxygenases: Repairing Nucleic Acid Alkylation Damage and Beyond [PDF]

, 2015
The AlkB family of Fe(II)- and α-ketoglutarate-dependent dioxygenases is a class of ubiquitous direct reversal DNA repair enzymes that remove alkyl adducts from nucleobases by oxidative dealkylation.
Delaney, James C., Essigmann, John M., Fedeles, Bogdan I., Li, Deyu, Singh, Vipender   +4 more
core   +1 more source

Insulin Resistance: An Update on Biochemical and Pathophysiological Mechanisms and Impact on Various Diseases

iNew Medicine, EarlyView.
ABSTRACT Insulin resistance is the biological phenomenon in which the human body's normal response to the metabolic hormone insulin is compromised. Insulin is a regulator of most of the essential metabolic steps in the body that control energy homoeostasis, so dysregulation leads to multiple diverse human diseases including, most prominently, Type 2 ...
Peter J. Little, Stefan Offermanns, Haaglim Cho, Zhiping Liu, Pinglian Yang, Qiaozhu Su, Henry Wade, Wah Yang, Danielle Kamato, Neale Cohen, Alex Bobik, Iqra Ilyas, Suowen Xu   +12 more
wiley   +1 more source

Dynamics of N6-methyladenosine modification during Alzheimer's disease development

Heliyon
N6-methyladenosine (m6A) modification is a common RNA modification in the central nervous system and has been linked to various neurological disorders, including Alzheimer's disease (AD).
Shuai Gao, Yuqing Wang, Xiaoyu Li, Yuqing Liang, Zhihao Jin, Baozhi Yang, Ti-Fei Yuan, Hengli Tian, Bo Peng, Yanxia Rao   +9 more
doaj   +1 more source

A reference genome and methylome for the Plasmodium knowlesi A1-H.1 line. [PDF]

, 2017
Plasmodium knowlesi, a common parasite of macaques, is recognised as a significant cause of human malaria in Malaysia. The P. knowlesi A1H1 line has been adapted to continuous culture in human erythrocytes, successfully providing an in vitro model to ...
Benavente, Ernest Diez, Blackman, Michael J, Campino, Susana, Clark, Taane G, de Sessions, Paola Florez, Drakeley, Christopher J, Grainger, Munira, Hibberd, Martin L, Holder, Anthony A, Moon, Robert W, Pain, Arnab, Roper, Cally, Sutherland, Colin J   +12 more
core   +1 more source

N6‐Methyladenosine (m6A) in Liver Disease: Pathogenic Mechanisms and Therapeutic Potential

iNew Medicine, EarlyView.
ABSTRACT Accumulating evidence highlights the critical role of epigenetic modifications, particularly N6‐methyladenosine (m6A), in liver disease. As the most abundant RNA modification in eukaryotic cells, m6A is dynamically regulated by multicomponent m6A methyltransferases (e.g., METTL3 and METTL14), demethylases (FTO and ALKBH5), and m6A‐binding ...
Yingfen Chen, Ru Ya, Ziling Zhang, Siyue Dong, Seol Hee Park, Wonhyo Seo, Yong He   +6 more
wiley   +1 more source

A System of RNA Modifications and Biased Codon Use Controls Cellular Stress Response at the Level of Translation [PDF]

, 2014
Cells respond to environmental stressors and xenobiotic exposures using regulatory networks to control gene expression, and there is an emerging appreciation for the role of numerous postsynthetic chemical modifications of DNA, RNA, and proteins in ...
Begley, Thomas J., Dedon, Peter C
core   +1 more source