Results 161 to 170 of about 23,657 (254)

Cardiomyocyte‐enriched OTUD5 alleviates septic cardiomyopathy by promoting NLRP3 deubiquitination and inhibiting NLRP3 inflammasome activation

Clinical and Translational Medicine, Volume 16, Issue 7, July 2026.
A schematic representation of cardiomyocyte‐enriched OTUD5 alleviates septic cardiomyopathy by promoting NLRP3 deubiquitination and inhibiting NLRP3 inflammasome activation. Abstract Background Septic cardiomyopathy (SCM) is the leading cause of mortality among patients diagnosed with sepsis.
Yucheng Jiang, Zhihan Jia, Zhaozheng Zheng, Yingjie Liao, Qingqing Zhao, Wante Lin, Diyun Xu, Naijin Zhang, Guang Liang, Bozhi Ye   +9 more
wiley   +1 more source

FTO-mediated m6A modification regulates the osteogenic differentiation of ADSCs by targeting FOXO1. [PDF]

Stem Cell Res Ther
Wang Z, Wen S, Li H, Wang X, Guo S, Yang S.   +5 more
europepmc   +1 more source

Bridging maternal effects and epitranscriptomics: A novel perspective in developmental biology

Developmental Dynamics, Volume 255, Issue 7, Page 628-645, July 2026.
Abstract Maternal effects, encompassing both genetic (maternally expressed gene products) and non‐genetic (maternal state) influences, are powerful determinants of offspring phenotype, yet their RNA‐level mechanisms remain incompletely resolved. In parallel, epitranscriptomics, an emerging field centered on chemical modifications to RNA, has revealed ...
Ehsan Pashay Ahi
wiley   +1 more source

M6A demethylase ALKBH5 mediated Igfbp4 mRNA m6A modification drives fibroblast activation and pathological upper airway fibrosis. [PDF]

Clin Transl Med
Wang J, Liao Z, Xu M, Zheng Y, Hu B, Xia Q, Xu H.   +6 more
europepmc   +1 more source

PKMYT1 in Cancer: Beyond Cell Cycle Checkpoints to Context‐Dependent Therapeutic Vulnerability

Genes, Chromosomes and Cancer, Volume 65, Issue 7, July 2026.
ABSTRACT PKMYT1 has emerged as a promising therapeutic target distinguished by its tumor‐selective expression and essential role in replication stress management. Unlike WEE1, PKMYT1 is dispensable in normal cell cycles but critical for cancer cells coping with DNA damage, establishing a broad therapeutic window.
Lingxi Li, Binfan He, Mengmeng Hao, Ye Liu, Shunxin Song, Rongzhang He   +5 more
wiley   +1 more source

The crosstalk of m6A modification and non-coding RNAs in gastric cancer: biomarkers and therapeutic potentials. [PDF]

Cancer Cell Int
Li P, Xue Y, Gu X.
europepmc   +1 more source

Immune, molecular and genetic profiles of gastric signet ring cell carcinoma: Recent progress and future challenges

International Journal of Cancer, Volume 159, Issue 1, Page 11-29, 1 July 2026.
Abstract Gastric signet ring cell carcinoma (GSRCC) is a special type of gastric cancer common in young women. Diffuse gastric cancer (DGC) begins with intramucosal lesions comprising differentiated GSRCC cells. Genetically, GSRCC and DGC are clonally identical, with their morphology influenced by extracellular Wnt signaling.
Qian Wang, Shuai Zhou, Xiongchao Fang, Xianli He, Gang Wang, Nan Wang   +5 more
wiley   +1 more source

The regulatory role of circGDI2 in hepatocellular carcinoma proliferation and glycolysis with the involvement of m6A modification. [PDF]

Noncoding RNA Res
Chen S, Xia H, Chen S.
europepmc   +1 more source

Salivary Extracellular Vesicles: Paradigm Shift in Liquid Biopsy Diagnostics

Journal of Extracellular Biology, Volume 5, Issue 7, July 2026.
ABSTRACT Extracellular vesicles (EVs), lipid bilayer nanoparticles released by virtually all cells, serve as essential messengers for intercellular communication. Due to their involvement in several pathophysiological processes, EVs have recently gained considerable attention as potentially diagnostic and prognostic biomarkers for various illnesses ...
Kwanele Xulu, Usri H. Ibrahim, Irene Mackraj, Carola Niesler   +3 more
wiley   +1 more source

m⁶A modification in skeletal system diseases (Review). [PDF]

Mol Med Rep
Xie X, Li C, Zheng H, Gan G, Gao X.
europepmc   +1 more source