The Kaohsiung Journal of Medical Sciences, Volume 42, Issue 7, July 2026.ABSTRACT Ibrutinib resistance remains a major obstacle in the treatment of diffuse large B‐cell lymphoma (DLBCL). Fat mass and obesity‐associated protein (FTO) has been implicated in drug resistance through its regulation of N6‐methyladenosine (m6A) modifications; however, whether FTO mediates ibrutinib resistance in DLBCL remains unclear.
Ting‐Ting Lu +5 more
wiley +1 more source
METTL3-mediated m6A modification of FDX1 confers resistance to cuproptosis and promotes hepatocellular carcinoma progression. [PDF]
Commun BiolJiang Q +9 more
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The Kaohsiung Journal of Medical Sciences, Volume 42, Issue 7, July 2026.ABSTRACT Radiotherapy effectively eradicates tumor cells but can also trigger pyroptotic damage in vascular endothelial cells. This study investigates the role of interferon regulatory factor 1 (IRF1) in radiation‐induced endothelial injury, aiming to provide mechanistic insights for optimizing radiotherapy.
Chen Li +4 more
wiley +1 more source
RBM15-Mediated m6A Modification Regulates Proliferation and Migration of Pancreatic Cancer Cells via the lncRNA LINC01320/miR-1287-5p/FBXO11 Axis. [PDF]
Biomol Ther (Seoul)Deng X, Wang B.
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RNA Modifications in Tumor Microenvironment: A New Dimension for Cancer Treatment
MedComm, Volume 7, Issue 7, July 2026.Tumor initiation and progression depend on a supportive and highly heterogeneous tumor microenvironment (TME). RNA modifications regulate signaling pathways and cytokine networks that shape TME dynamics, facilitating interactions between cancer cells and noncancerous stromal cells, and ultimately promoting immune evasion and tumor progression ...
Qiwen Li +3 more
wiley +1 more source
HIV-1 Vpr activates microglia by upregulating m6A modification through ubiquitin-proteasome pathway-mediated degradation of the demethylase ALKBH5. [PDF]
VirulencePeng Q +11 more
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Intratumoral Microbiota in Tumor: Current Understandings and Future Perspectives
MedComm, Volume 7, Issue 7, July 2026.Intratumoral bacteria are emerging as active regulators of cancer evolution rather than bystanders. This review outlines how tumor‐resident microbes drive tumor initiation and growth by inducing genomic instability, epigenetic reprogramming, oncogenic signaling, and chronic inflammation, while promoting metastatic spread via invasion, angiogenesis ...
Jiawei Chen +6 more
wiley +1 more source
METTL3 promotes pancreatic cancer immune escape by m6A modification of lncRNA AFAP1-AS1 to enhance EGR2 stability. [PDF]
Eur J Med ResZhu D, Shen R, Li M.
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Cellular Senescence and Aging: Mechanisms, Disease Convergence, and Therapeutic Frontiers
MedComm, Volume 7, Issue 7, July 2026.This schematic illustrates the hierarchical and interconnected nature of the primary molecular hallmarks of aging. The progression of aging is driven by a convergence of intrinsic molecular insults. Within the nucleus, genomic instability and telomere attrition trigger persistent DDR, accompanied by extensive epigenetic alterations.
Guowei Cai +10 more
wiley +1 more source
RBM15 promotes COAD progression by regulating the m6A modification of TMC5. [PDF]
HereditasTian E, Gao L, Wu L, Qin L.
europepmc +1 more source