MedComm, Volume 7, Issue 7, July 2026.Upregulation of NNMT in ccRCC is associated with tumor stage and poor prognosis. Mechanistically, NNMT reduces SAM levels, thereby decreasing H3K9me3 modification and promoting FN1 transcription. NNMT inhibitor effectively suppresses tumor progression, providing compelling evidence for its potential as a novel target for therapeutic intervention in ...
Lingling Wang +7 more
wiley +1 more source
YTHDF2 enhances proliferation and metastasis of nasopharyngeal carcinoma by mediating m6A modification in destabilizing FOXO1 mRNA. [PDF]
Cancer Biol TherYu P +6 more
europepmc +1 more source
Multiple Roles of Protamine Kinase SRPK1 and Phosphatase PP1γ in Sperm Development
PROTEOMICS, Volume 26, Issue 7, Page 42-56, July 2026.ABSTRACT Protein phosphorylation regulates key events of male germ cell differentiation. In the testis, SRPK1 and PP1γ are involved in protamine phosphorylation and dephosphorylation, respectively, and their deregulation is linked to defective chromatin structure and male infertility.
Alberto de la Iglesia +7 more
wiley +1 more source
The role of m6A modification in non-small cell lung cancer: functional insights and impact on therapy resistance. [PDF]
Cancer Cell IntYang Y, Shi Y, Tao Z, Ma Y, Zhao J.
europepmc +1 more source
From Cold to Hot: Nanozyme‐Based Strategies for Reprogramming the Tumour Immunoenvironment
Cell Proliferation, Volume 59, Issue 7, July 2026.Nanozymes, with multi‐enzyme catalytic activities, reprogram the immunosuppressive tumour microenvironment by inducing immunogenic cell death, relieving hypoxia, and depleting antioxidants, effectively converting immunologically “cold” tumours into “hot” ones to boost cancer immunotherapy efficacy.
Yue Wang +9 more
wiley +1 more source
Genome-wide profiling of m6A modification and its role in the transcriptome of sequelae of pelvic inflammatory disease. [PDF]
Medicine (Baltimore)Zhang M, Xu Y, Jiang Y.
europepmc +1 more source
Clinical and Translational Science, Volume 19, Issue 7, July 2026.This study employed an integrated multi‐omics screening strategy incorporating GEO database differential expression analysis, GWAS‐eQTL genetic association analysis, and single‐cell RNA‐seq cell subpopulation localization to identify EPHX2 as a core causal gene in ulcerative colitis (UC).
Tian Dai +8 more
wiley +1 more source
LncRNA AC040169.1 is regulated by m6A modification and suppresses ferroptosis via SLC7A11 to promote ovarian cancer progression. [PDF]
J Ovarian ResYang H, Dong Y, Li R, Zhu L, Yang L.
europepmc +1 more source
The Role of Long Noncoding RNAs in Modulation of Stress Granules in Cancer
Journal of Cellular and Molecular Medicine, Volume 30, Issue 13, July 2026.ABSTRACT Stress granules are dynamic cellular structures that arise in response to stress. They play an important role in cancer cell survival by modulating multiple stress responses. Long noncoding RNAs (lncRNAs) have been identified as crucial regulators of stress granule (SG) dynamics, influencing cancer development and treatment resistance. LncRNAs
Nazlı Şevval Menemenli +1 more
wiley +1 more source
Unveiling the role of m6A modification in esophageal cancer: a new frontier in tumor innate interferon immunity. [PDF]
Cancer Cell IntZuo X, Liu G, Guo J, Wang Y.
europepmc +1 more source