Results 71 to 80 of about 3,186 (156)

Roles of Toll-like receptor 2/4, monoacylglycerol lipase, and cyclooxygenase in social defeat stress-induced prostaglandin E2 synthesis in the brain and their behavioral relevance

Scientific Reports, 2019
Inflammation in the brain and periphery has been associated with stress-related pathology of mental illness. We have shown that prostaglandin (PG) E2, an arachidonic acid-derived lipid mediator, and innate immune receptors Toll-like receptor (TLR) 2/4 ...
Xiang Nie, Shiho Kitaoka, Masakazu Shinohara, Akira Kakizuka, Shuh Narumiya, Tomoyuki Furuyashiki   +5 more
doaj   +1 more source

Near‐Source Ammonia (NH3) Fluxes and Evolution Observed From Airborne Measurements in Plumes Up To 25 km Downwind From Large Beef Cattle Facilities

Journal of Geophysical Research: Atmospheres, Volume 130, Issue 19, 16 October 2025.
Abstract The Transport and Transformation of Ammonia (TRANS2Am) campaign took place in northeastern Colorado in the summers of 2021 and 2022. One of the goals of TRANS2Am was to study the evolution of ammonia (NH3) in plumes from large animal feeding operations.
Julieta F. Juncosa Calahorrano, Amy P. Sullivan, Ilana B. Pollack, Joseph Robert Roscioli, Dana R. Caulton, Megan E. McCabe, Kathryn M. Steinmann, En Li, Jeffrey R. Pierce, Lillian E. Naimie, Da Pan, Jeffrey L. Collett Jr., Emily V. Fischer   +12 more
wiley   +1 more source

Morphological variations of the ovarian follicles and oviduct of commercial Lohmann Brown and indigenous Potchefstroom Koekoek breeds

Acta Zoologica, Volume 106, Issue 4, Page 454-462, October 2025.
Abstract Egg laying begins with the orderly development of follicles in the chicken ovaries and transportation through the oviduct with deposition of nutrients until the eggs are produced. However, the ovarian follicles and oviduct morphology of Lohmann Brown and Potchefstroom Koekoek laying hens have not yet been studied.
Victoria Rankotsane Hlokoe, Thobela Louis Tyasi, Vusi Gordon Mbazima   +2 more
wiley   +1 more source

Paradoxical effects of JZL184, an inhibitor of monoacylglycerol lipase, on bone remodelling in healthy and cancer-bearing miceResearch in context

EBioMedicine, 2019
Background: Cancer-associated bone disease is a serious complication in bone sarcomas and metastatic carcinomas of breast and prostate origin. Monoacylglycerol lipase (MAGL) is an enzyme of the endocannabinoid system, and is responsible for the ...
Silvia Marino, Daniëlle de Ridder, Ryan T. Bishop, Nathalie Renema, Marco Ponzetti, Antonia Sophocleous, Mattia Capulli, Abdullah Aljeffery, Giovana Carrasco, Marianela Dalghi Gens, Asim Khogeer, Stuart H. Ralston, Jürg Gertsch, Francois Lamoureux, Dominique Heymann, Nadia Rucci, Aymen I. Idris   +16 more
doaj   +1 more source

Inhibition of 2-AG hydrolysis differentially regulates blood brain barrier permeability after injury

Journal of Neuroinflammation, 2018
Background Acute neurological insults caused by infection, systemic inflammation, ischemia, or traumatic injury are often associated with breakdown of the blood-brain barrier (BBB) followed by infiltration of peripheral immune cells, cytotoxic proteins ...
Justin R. Piro, Georgette L. Suidan, Jie Quan, YeQing Pi, Sharon M. O’Neill, Marissa Ilardi, Nikolay Pozdnyakov, Thomas A. Lanz, Hualin Xi, Robert D. Bell, Tarek A. Samad   +10 more
doaj   +1 more source

NEKE POETSKE OSOBENOSTI U ROMANU „CRVENE MAGLE“ DRAGIŠE VASIĆA

Nasledje Kragujevac, 2023
The paper discusses some peculiarities of the novel Crvene Magle (Red Mists) by Dragiša Vasić in the light of the poetry of a lyrical expressionist novel. We select and process examples from Vasić’s corpus related to the most prominent characteristics of a lyrical novel, primar- ily the world of oneirism, lyricism, and sensuality, as well as poetic ...
openaire   +2 more sources

Novel Oxazine Monoacylglycerol Lipase (MAGL) Inhibitors [PDF]

ACS Medicinal Chemistry Letters, 2021
openaire   +2 more sources

Levels of endocannabinoid metabolizing enzymes are not related with BDNF levels in patients with schizophrenia: a case-controlled study

Psychiatry and Clinical Psychopharmacology, 2019
PURPOSE: While the pathogenesis of schizophrenia has yet to be fully clarified, a huge amount of data suggests the involvement of endocannabinoid system and neurotrophic factors in schizophrenia.
Mehmet Cemal Kaya, Mahmut Bulut, İbrahim Kaplan, Mehmet Gunes   +3 more
doaj   +1 more source

Discovery of long-chain salicylketoxime derivatives as monoacylglycerol lipase (MAGL) inhibitors

European Journal of Medicinal Chemistry, 2018
Monoacylglycerol lipase (MAGL) is the enzyme hydrolyzing the endocannabinoid 2-arachidonoylglycerol (2-AG) to free arachidonic acid and glycerol. Therefore, MAGL is implicated in many physiological processes involving the regulation of the endocannabinoid system and eicosanoid network.
Bononi, Giulia, Granchi, Carlotta, Lapillo, Margherita, Giannotti, Massimiliano, Nieri, Daniela, Fortunato, Serena, Boustani, Maguie El, Caligiuri, Isabella, Poli, Giulio, Carlson, Kathryn E., Kim, Sung Hoon, Macchia, Marco, Martinelli, Adriano, Rizzolio, Flavio, Chicca, Andrea, Katzenellenbogen, John A., Minutolo, Filippo, Tuccinardi, Tiziano   +17 more
openaire   +2 more sources

Endocannabinoid Hydrolase Inhibitors: Potential Novel Anxiolytic Drugs

Drug Design, Development and Therapy
Hongqing Zhao,1,2,* Yang Liu,1,2,* Na Cai,3 Xiaolin Liao,1,2 Lin Tang,2,4 Yuhong Wang1,2 1Science & Technology Innovation Center, Hunan University of Chinese Medicine, Changsha, Hunan, People’s Republic of China; 2Hunan Key Laboratory of ...
Zhao H, Liu Y, Cai N, Liao X, Tang L, Wang Y   +5 more
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